General obesity, abdominal obesity, and the risk of cardiovascular disease including stroke in 5-year breast cancer survivors
Background: To assess the association between discrepancies between general obesity and abdominal obesity and the risk of subsequent cardiovascular disease (CVD), including stroke, in breast cancer survivors. Methods: We undertook a retrospective cohort study using data from the National Health Insu...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Breast |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977624001887 |
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| author | Ji Soo Kim Jihun Song Seulggie Choi Sang Min Park |
| author_facet | Ji Soo Kim Jihun Song Seulggie Choi Sang Min Park |
| author_sort | Ji Soo Kim |
| collection | DOAJ |
| description | Background: To assess the association between discrepancies between general obesity and abdominal obesity and the risk of subsequent cardiovascular disease (CVD), including stroke, in breast cancer survivors. Methods: We undertook a retrospective cohort study using data from the National Health Insurance Service of South Korea. Among 72,174 5-year breast cancer survivors aged 40 years and above, body mass index (BMI) and waist circumference (WC) were used to determine obesity status. Cox proportional hazards models were used to evaluate the association of obesity and risk of CVD, including stroke. Results: Compared to those with normal WC and BMI, those who were overweight without abdominal obesity, had abdominal obesity only, and overweight with abdominal obesity, had higher risks of CVD [aHR(95 % CI) 1.23(1.02–1.48), 1.51(1.16–1.95), and 1.55(1.31–1.75), respectively] and total stroke [1.09(0.86–1.38), 1.63(1.20–2.23), and 1.40(1.17–1.68), respectively]. Compared to those overweight, those with abdominal obesity only had a significantly higher risk of ischemic stroke [2.04(1.14–3.65)]. Conclusions: Breast cancer survivors with higher BMI and/or abdominal obesity were associated with an elevated risk of CVD, including stroke. |
| format | Article |
| id | doaj-art-c47a406a544f446cacb0f52f66ac0801 |
| institution | Kabale University |
| issn | 1532-3080 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj-art-c47a406a544f446cacb0f52f66ac08012025-02-12T05:30:35ZengElsevierBreast1532-30802025-02-0179103857General obesity, abdominal obesity, and the risk of cardiovascular disease including stroke in 5-year breast cancer survivorsJi Soo Kim0Jihun Song1Seulggie Choi2Sang Min Park3International Healthcare Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, South KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South KoreaDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea; Department of Family Medicine, Seoul National University Hospital, Seoul, South Korea; Corresponding author. Department of Family Medicine, Seoul National University Hospital 101, Daehak-ro, Jongno-gu, Seoul, South Korea.Background: To assess the association between discrepancies between general obesity and abdominal obesity and the risk of subsequent cardiovascular disease (CVD), including stroke, in breast cancer survivors. Methods: We undertook a retrospective cohort study using data from the National Health Insurance Service of South Korea. Among 72,174 5-year breast cancer survivors aged 40 years and above, body mass index (BMI) and waist circumference (WC) were used to determine obesity status. Cox proportional hazards models were used to evaluate the association of obesity and risk of CVD, including stroke. Results: Compared to those with normal WC and BMI, those who were overweight without abdominal obesity, had abdominal obesity only, and overweight with abdominal obesity, had higher risks of CVD [aHR(95 % CI) 1.23(1.02–1.48), 1.51(1.16–1.95), and 1.55(1.31–1.75), respectively] and total stroke [1.09(0.86–1.38), 1.63(1.20–2.23), and 1.40(1.17–1.68), respectively]. Compared to those overweight, those with abdominal obesity only had a significantly higher risk of ischemic stroke [2.04(1.14–3.65)]. Conclusions: Breast cancer survivors with higher BMI and/or abdominal obesity were associated with an elevated risk of CVD, including stroke.http://www.sciencedirect.com/science/article/pii/S0960977624001887Abdominal obesityCardiovascular diseaseStrokeBreast cancer |
| spellingShingle | Ji Soo Kim Jihun Song Seulggie Choi Sang Min Park General obesity, abdominal obesity, and the risk of cardiovascular disease including stroke in 5-year breast cancer survivors Breast Abdominal obesity Cardiovascular disease Stroke Breast cancer |
| title | General obesity, abdominal obesity, and the risk of cardiovascular disease including stroke in 5-year breast cancer survivors |
| title_full | General obesity, abdominal obesity, and the risk of cardiovascular disease including stroke in 5-year breast cancer survivors |
| title_fullStr | General obesity, abdominal obesity, and the risk of cardiovascular disease including stroke in 5-year breast cancer survivors |
| title_full_unstemmed | General obesity, abdominal obesity, and the risk of cardiovascular disease including stroke in 5-year breast cancer survivors |
| title_short | General obesity, abdominal obesity, and the risk of cardiovascular disease including stroke in 5-year breast cancer survivors |
| title_sort | general obesity abdominal obesity and the risk of cardiovascular disease including stroke in 5 year breast cancer survivors |
| topic | Abdominal obesity Cardiovascular disease Stroke Breast cancer |
| url | http://www.sciencedirect.com/science/article/pii/S0960977624001887 |
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