Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa
BackgroundMultisystem inflammatory syndrome in children (MIS-C) is a disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its short-term effects have been documented but little data exist on the longer term effects of MIS-C on the health and quality of...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1465976/full |
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| author | Frank Phoya Claire Butters Timothy F. Spracklen Timothy F. Spracklen Hanna L. Kassa Hamza van der Ross Chris Scott Kate Webb Kate Webb |
| author_facet | Frank Phoya Claire Butters Timothy F. Spracklen Timothy F. Spracklen Hanna L. Kassa Hamza van der Ross Chris Scott Kate Webb Kate Webb |
| author_sort | Frank Phoya |
| collection | DOAJ |
| description | BackgroundMultisystem inflammatory syndrome in children (MIS-C) is a disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its short-term effects have been documented but little data exist on the longer term effects of MIS-C on the health and quality of life (QOL) of patients. The objective of this study was to assess the long-term effects of MIS-C on the QOL of children.MethodsThis study was a descriptive prospective study. We included 24 participants with previous MIS-C and 20 children with juvenile idiopathic arthritis (JIA) as a positive comparator group. All children were examined and completed a paediatric quality of life (PedsQL) generic inventory score. This score was used to evaluate the School Functioning, Social, Emotional, and Physical QOL domains.ResultsAll participants with previous MIS-C made a full recovery, with no medical complaints, and normal physical examinations after a median of 705 days post acute diagnosis. The PedsQL inventory revealed that 16.7% of the children with previous MIS-C showed a deficit in the physical domain compared to 60% of the children with JIA (p < 0.001). 12.5% of the children with previous MIS-C had a deficit in their psychosocial domain which included emotional, social, and educational scores, compared to 40% of the children with JIA (p = 0.035).ConclusionsIn a cohort of 24 South African children with previous MIS-C, no medical complications were reported. A small proportion felt a prolonged effect on their QOL even after making a full recovery, although this was not as severe as children with JIA, a known chronic disease that affects QOL. This highlights the need to continue to follow up these patients and offer more comprehensive long-term care. |
| format | Article |
| id | doaj-art-c5a5e288c997486eac55b64c1b860c10 |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-c5a5e288c997486eac55b64c1b860c102025-02-07T14:34:33ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011210.3389/fped.2024.14659761465976Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South AfricaFrank Phoya0Claire Butters1Timothy F. Spracklen2Timothy F. Spracklen3Hanna L. Kassa4Hamza van der Ross5Chris Scott6Kate Webb7Kate Webb8Division of Rheumatology, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South AfricaDivision of Rheumatology, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South AfricaDivision of Rheumatology, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South AfricaCape Heart Institute & Children’s Heart Disease Research Unit, University of Cape Town, Cape Town, South AfricaDivision of Rheumatology, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South AfricaDivision of Rheumatology, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South AfricaDivision of Rheumatology, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South AfricaDivision of Rheumatology, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South AfricaCrick African Network, Francis Crick Institute, London, United KingdomBackgroundMultisystem inflammatory syndrome in children (MIS-C) is a disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its short-term effects have been documented but little data exist on the longer term effects of MIS-C on the health and quality of life (QOL) of patients. The objective of this study was to assess the long-term effects of MIS-C on the QOL of children.MethodsThis study was a descriptive prospective study. We included 24 participants with previous MIS-C and 20 children with juvenile idiopathic arthritis (JIA) as a positive comparator group. All children were examined and completed a paediatric quality of life (PedsQL) generic inventory score. This score was used to evaluate the School Functioning, Social, Emotional, and Physical QOL domains.ResultsAll participants with previous MIS-C made a full recovery, with no medical complaints, and normal physical examinations after a median of 705 days post acute diagnosis. The PedsQL inventory revealed that 16.7% of the children with previous MIS-C showed a deficit in the physical domain compared to 60% of the children with JIA (p < 0.001). 12.5% of the children with previous MIS-C had a deficit in their psychosocial domain which included emotional, social, and educational scores, compared to 40% of the children with JIA (p = 0.035).ConclusionsIn a cohort of 24 South African children with previous MIS-C, no medical complications were reported. A small proportion felt a prolonged effect on their QOL even after making a full recovery, although this was not as severe as children with JIA, a known chronic disease that affects QOL. This highlights the need to continue to follow up these patients and offer more comprehensive long-term care.https://www.frontiersin.org/articles/10.3389/fped.2024.1465976/fullMIS-C (multisystem inflammatory syndrome in children)quality of lifejuvenile idiopathic arthiritisSouth Africaphysical deficits |
| spellingShingle | Frank Phoya Claire Butters Timothy F. Spracklen Timothy F. Spracklen Hanna L. Kassa Hamza van der Ross Chris Scott Kate Webb Kate Webb Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa Frontiers in Pediatrics MIS-C (multisystem inflammatory syndrome in children) quality of life juvenile idiopathic arthiritis South Africa physical deficits |
| title | Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa |
| title_full | Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa |
| title_fullStr | Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa |
| title_full_unstemmed | Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa |
| title_short | Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa |
| title_sort | medium term health and quality of life outcomes in a cohort of children with mis c in cape town south africa |
| topic | MIS-C (multisystem inflammatory syndrome in children) quality of life juvenile idiopathic arthiritis South Africa physical deficits |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1465976/full |
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