The assessment of the facial skin microbiota in patients with seborrheic dermatitis and metabolic syndrome
Background. Currently, the attention of dermatologists is often directed to the study of changes in bacterial colonization of the skin, as one of the important links in the pathogenesis of skin diseases, including psoriasis, atopic dermatitis, acne, and seborrheic dermatitis. In recent years, data h...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
State Scientific Center of Dermatovenereology and Cosmetology
2024-12-01
|
| Series: | Vestnik Dermatologii i Venerologii |
| Subjects: | |
| Online Access: | https://vestnikdv.ru/jour/article/viewFile/16761/pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832095358549753856 |
|---|---|
| author | Kristina Yu. Molodykh Elena R. Araviiskaia Evgeny V. Sokolovskiy Lyudmila A. Kraeva |
| author_facet | Kristina Yu. Molodykh Elena R. Araviiskaia Evgeny V. Sokolovskiy Lyudmila A. Kraeva |
| author_sort | Kristina Yu. Molodykh |
| collection | DOAJ |
| description | Background. Currently, the attention of dermatologists is often directed to the study of changes in bacterial colonization of the skin, as one of the important links in the pathogenesis of skin diseases, including psoriasis, atopic dermatitis, acne, and seborrheic dermatitis. In recent years, data have emerged indicating a direct link between changes in the composition of the skin microbiota and obesity, as well as related diseases, primarily type 2 diabetes mellitus.
The aims. To give a clinical and microbiological characteristic of seborrheic dermatitis of the face in persons with metabolic syndrome and type 2 diabetes mellitus and in persons without concomitant pathology.
Methods. The study included 90 patients with seborrheic dermatitis, divided into 3 groups (1 — patients with seborrheic dermatitis; 2 — patients with seborrheic dermatitis and metabolic syndrome; 3 — patients with seborrheic dermatitis, metabolic syndrome and diabetes mellitus). The severity of the disease was determined by SEDASI score (Seborrheic Dermatitis Area and Severity Index). Metabolic syndrome was diagnosed based on the criteria of NCEP ATP III. The diagnosis of diabetes mellitus was established according to the diagnostic criteria of diabetes mellitus and other glycemic disorders (World Health Organization, 1999–2013). Classical bacteriological methods and mass spectrometric method (MALDI-TOF MS) were used to study the skin microbiome.
Results. Our study revealed an association between the presence of certain microorganisms in the skin microbiome and seborrheic dermatitis, metabolic syndrome and type 2 diabetes mellitus. In patients with moderate to severe seborrheic dermatitis, an increase in bacterial species isolated from the skin surface and their number in the unit volume of the investigated material. It was found that the colonization of microorganisms on the facial skin was significantly higher in patients of groups 2 and 3 compared to group 1. Among the isolated representatives of the genus Staphylococcus, the most pathogenic species of S. aureus prevailed in patients of groups 2 and 3.
Conclusion. The severity of the course and widespread lesions on the facial skin in patients with seborrheic dermatitis, metabolic syndrome and with seborrheic dermatitis, metabolic syndrome and type 2 diabetes mellitus are interrelated with disorders of facial skin microbiota. The growth of microorganisms in patients with seborrheic dermatitis and carbohydrate metabolism disorder is associated with severe course of facial seborrheic dermatitis and plays a significant role in the pathogenesis of the disease. |
| format | Article |
| id | doaj-art-c7b5547518df4c58ae9a15ac0e1fd6a7 |
| institution | Kabale University |
| issn | 0042-4609 2313-6294 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | State Scientific Center of Dermatovenereology and Cosmetology |
| record_format | Article |
| series | Vestnik Dermatologii i Venerologii |
| spelling | doaj-art-c7b5547518df4c58ae9a15ac0e1fd6a72025-02-05T20:41:44ZengState Scientific Center of Dermatovenereology and CosmetologyVestnik Dermatologii i Venerologii0042-46092313-62942024-12-011006616910.25208/vdv167611314The assessment of the facial skin microbiota in patients with seborrheic dermatitis and metabolic syndromeKristina Yu. Molodykh0https://orcid.org/0000-0001-5479-5652Elena R. Araviiskaia1https://orcid.org/0000-0002-6378-8582Evgeny V. Sokolovskiy2https://orcid.org/0000-0001-7610-6061Lyudmila A. Kraeva3https://orcid.org/0000-0002-9115-3250Pavlov First Saint Petersburg State Medical UniversityPavlov First Saint Petersburg State Medical UniversityPavlov First Saint Petersburg State Medical UniversityPavlov First Saint Petersburg State Medical UniversityBackground. Currently, the attention of dermatologists is often directed to the study of changes in bacterial colonization of the skin, as one of the important links in the pathogenesis of skin diseases, including psoriasis, atopic dermatitis, acne, and seborrheic dermatitis. In recent years, data have emerged indicating a direct link between changes in the composition of the skin microbiota and obesity, as well as related diseases, primarily type 2 diabetes mellitus. The aims. To give a clinical and microbiological characteristic of seborrheic dermatitis of the face in persons with metabolic syndrome and type 2 diabetes mellitus and in persons without concomitant pathology. Methods. The study included 90 patients with seborrheic dermatitis, divided into 3 groups (1 — patients with seborrheic dermatitis; 2 — patients with seborrheic dermatitis and metabolic syndrome; 3 — patients with seborrheic dermatitis, metabolic syndrome and diabetes mellitus). The severity of the disease was determined by SEDASI score (Seborrheic Dermatitis Area and Severity Index). Metabolic syndrome was diagnosed based on the criteria of NCEP ATP III. The diagnosis of diabetes mellitus was established according to the diagnostic criteria of diabetes mellitus and other glycemic disorders (World Health Organization, 1999–2013). Classical bacteriological methods and mass spectrometric method (MALDI-TOF MS) were used to study the skin microbiome. Results. Our study revealed an association between the presence of certain microorganisms in the skin microbiome and seborrheic dermatitis, metabolic syndrome and type 2 diabetes mellitus. In patients with moderate to severe seborrheic dermatitis, an increase in bacterial species isolated from the skin surface and their number in the unit volume of the investigated material. It was found that the colonization of microorganisms on the facial skin was significantly higher in patients of groups 2 and 3 compared to group 1. Among the isolated representatives of the genus Staphylococcus, the most pathogenic species of S. aureus prevailed in patients of groups 2 and 3. Conclusion. The severity of the course and widespread lesions on the facial skin in patients with seborrheic dermatitis, metabolic syndrome and with seborrheic dermatitis, metabolic syndrome and type 2 diabetes mellitus are interrelated with disorders of facial skin microbiota. The growth of microorganisms in patients with seborrheic dermatitis and carbohydrate metabolism disorder is associated with severe course of facial seborrheic dermatitis and plays a significant role in the pathogenesis of the disease.https://vestnikdv.ru/jour/article/viewFile/16761/pdfseborrheic dermatitismetabolic syndromeskin microbiota |
| spellingShingle | Kristina Yu. Molodykh Elena R. Araviiskaia Evgeny V. Sokolovskiy Lyudmila A. Kraeva The assessment of the facial skin microbiota in patients with seborrheic dermatitis and metabolic syndrome Vestnik Dermatologii i Venerologii seborrheic dermatitis metabolic syndrome skin microbiota |
| title | The assessment of the facial skin microbiota in patients with seborrheic dermatitis and metabolic syndrome |
| title_full | The assessment of the facial skin microbiota in patients with seborrheic dermatitis and metabolic syndrome |
| title_fullStr | The assessment of the facial skin microbiota in patients with seborrheic dermatitis and metabolic syndrome |
| title_full_unstemmed | The assessment of the facial skin microbiota in patients with seborrheic dermatitis and metabolic syndrome |
| title_short | The assessment of the facial skin microbiota in patients with seborrheic dermatitis and metabolic syndrome |
| title_sort | assessment of the facial skin microbiota in patients with seborrheic dermatitis and metabolic syndrome |
| topic | seborrheic dermatitis metabolic syndrome skin microbiota |
| url | https://vestnikdv.ru/jour/article/viewFile/16761/pdf |
| work_keys_str_mv | AT kristinayumolodykh theassessmentofthefacialskinmicrobiotainpatientswithseborrheicdermatitisandmetabolicsyndrome AT elenararaviiskaia theassessmentofthefacialskinmicrobiotainpatientswithseborrheicdermatitisandmetabolicsyndrome AT evgenyvsokolovskiy theassessmentofthefacialskinmicrobiotainpatientswithseborrheicdermatitisandmetabolicsyndrome AT lyudmilaakraeva theassessmentofthefacialskinmicrobiotainpatientswithseborrheicdermatitisandmetabolicsyndrome AT kristinayumolodykh assessmentofthefacialskinmicrobiotainpatientswithseborrheicdermatitisandmetabolicsyndrome AT elenararaviiskaia assessmentofthefacialskinmicrobiotainpatientswithseborrheicdermatitisandmetabolicsyndrome AT evgenyvsokolovskiy assessmentofthefacialskinmicrobiotainpatientswithseborrheicdermatitisandmetabolicsyndrome AT lyudmilaakraeva assessmentofthefacialskinmicrobiotainpatientswithseborrheicdermatitisandmetabolicsyndrome |