Midazolam nasal spray to treat intermittent, stereotypic episodes of frequent seizure activity: pharmacology and clinical role, a comprehensive review
An intranasal formulation of midazolam, Nayzilam, has been FDA-approved to treat intermittent, stereotypic episodes of frequent seizure activity. Nayzilam is easy to administer and can quickly treat seizures that occur outside of the hospital. The intra-nasal route of administration allows non-medic...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Open Medical Publishing
2022-10-01
|
| Series: | Health Psychology Research |
| Online Access: | https://doi.org/10.52965/001c.38536 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825139351479123968 |
|---|---|
| author | Elyse M. Cornett Meskerem A. Nemomsa Bailey Turbeville Matthew A. Busby Jessica S. Kaye Aaron J. Kaye JooHee Choi Giovanni F. Ramírez Giustino Varrassi Adam M. Kaye Alan D. Kaye James Wilson Latha Ganti |
| author_facet | Elyse M. Cornett Meskerem A. Nemomsa Bailey Turbeville Matthew A. Busby Jessica S. Kaye Aaron J. Kaye JooHee Choi Giovanni F. Ramírez Giustino Varrassi Adam M. Kaye Alan D. Kaye James Wilson Latha Ganti |
| author_sort | Elyse M. Cornett |
| collection | DOAJ |
| description | An intranasal formulation of midazolam, Nayzilam, has been FDA-approved to treat intermittent, stereotypic episodes of frequent seizure activity. Nayzilam is easy to administer and can quickly treat seizures that occur outside of the hospital. The intra-nasal route of administration allows non-medical personal to administer the drug which makes it more accessible and user-friendly in the event of a seizure. Many studies have indicated quick cessation of seizures with Nayzilam compared to rectal diazepam, which has been the standard of care treatment. Nayzilam has been proven to be safe and effective for acute seizures in children, deeming it a revolutionary alternative in times where intravenous administration is not possible. |
| format | Article |
| id | doaj-art-c9e47bdb96dd47ce9ec6a91c04faa9e9 |
| institution | Kabale University |
| issn | 2420-8124 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Open Medical Publishing |
| record_format | Article |
| series | Health Psychology Research |
| spelling | doaj-art-c9e47bdb96dd47ce9ec6a91c04faa9e92025-02-11T20:30:40ZengOpen Medical PublishingHealth Psychology Research2420-81242022-10-01105Midazolam nasal spray to treat intermittent, stereotypic episodes of frequent seizure activity: pharmacology and clinical role, a comprehensive reviewElyse M. CornettMeskerem A. NemomsaBailey TurbevilleMatthew A. BusbyJessica S. KayeAaron J. KayeJooHee ChoiGiovanni F. RamírezGiustino VarrassiAdam M. KayeAlan D. KayeJames WilsonLatha GantiAn intranasal formulation of midazolam, Nayzilam, has been FDA-approved to treat intermittent, stereotypic episodes of frequent seizure activity. Nayzilam is easy to administer and can quickly treat seizures that occur outside of the hospital. The intra-nasal route of administration allows non-medical personal to administer the drug which makes it more accessible and user-friendly in the event of a seizure. Many studies have indicated quick cessation of seizures with Nayzilam compared to rectal diazepam, which has been the standard of care treatment. Nayzilam has been proven to be safe and effective for acute seizures in children, deeming it a revolutionary alternative in times where intravenous administration is not possible.https://doi.org/10.52965/001c.38536 |
| spellingShingle | Elyse M. Cornett Meskerem A. Nemomsa Bailey Turbeville Matthew A. Busby Jessica S. Kaye Aaron J. Kaye JooHee Choi Giovanni F. Ramírez Giustino Varrassi Adam M. Kaye Alan D. Kaye James Wilson Latha Ganti Midazolam nasal spray to treat intermittent, stereotypic episodes of frequent seizure activity: pharmacology and clinical role, a comprehensive review Health Psychology Research |
| title | Midazolam nasal spray to treat intermittent, stereotypic episodes of frequent seizure activity: pharmacology and clinical role, a comprehensive review |
| title_full | Midazolam nasal spray to treat intermittent, stereotypic episodes of frequent seizure activity: pharmacology and clinical role, a comprehensive review |
| title_fullStr | Midazolam nasal spray to treat intermittent, stereotypic episodes of frequent seizure activity: pharmacology and clinical role, a comprehensive review |
| title_full_unstemmed | Midazolam nasal spray to treat intermittent, stereotypic episodes of frequent seizure activity: pharmacology and clinical role, a comprehensive review |
| title_short | Midazolam nasal spray to treat intermittent, stereotypic episodes of frequent seizure activity: pharmacology and clinical role, a comprehensive review |
| title_sort | midazolam nasal spray to treat intermittent stereotypic episodes of frequent seizure activity pharmacology and clinical role a comprehensive review |
| url | https://doi.org/10.52965/001c.38536 |
| work_keys_str_mv | AT elysemcornett midazolamnasalspraytotreatintermittentstereotypicepisodesoffrequentseizureactivitypharmacologyandclinicalroleacomprehensivereview AT meskeremanemomsa midazolamnasalspraytotreatintermittentstereotypicepisodesoffrequentseizureactivitypharmacologyandclinicalroleacomprehensivereview AT baileyturbeville midazolamnasalspraytotreatintermittentstereotypicepisodesoffrequentseizureactivitypharmacologyandclinicalroleacomprehensivereview AT matthewabusby midazolamnasalspraytotreatintermittentstereotypicepisodesoffrequentseizureactivitypharmacologyandclinicalroleacomprehensivereview AT jessicaskaye midazolamnasalspraytotreatintermittentstereotypicepisodesoffrequentseizureactivitypharmacologyandclinicalroleacomprehensivereview AT aaronjkaye midazolamnasalspraytotreatintermittentstereotypicepisodesoffrequentseizureactivitypharmacologyandclinicalroleacomprehensivereview AT jooheechoi midazolamnasalspraytotreatintermittentstereotypicepisodesoffrequentseizureactivitypharmacologyandclinicalroleacomprehensivereview AT giovanniframirez midazolamnasalspraytotreatintermittentstereotypicepisodesoffrequentseizureactivitypharmacologyandclinicalroleacomprehensivereview AT giustinovarrassi midazolamnasalspraytotreatintermittentstereotypicepisodesoffrequentseizureactivitypharmacologyandclinicalroleacomprehensivereview AT adammkaye midazolamnasalspraytotreatintermittentstereotypicepisodesoffrequentseizureactivitypharmacologyandclinicalroleacomprehensivereview AT alandkaye midazolamnasalspraytotreatintermittentstereotypicepisodesoffrequentseizureactivitypharmacologyandclinicalroleacomprehensivereview AT jameswilson midazolamnasalspraytotreatintermittentstereotypicepisodesoffrequentseizureactivitypharmacologyandclinicalroleacomprehensivereview AT lathaganti midazolamnasalspraytotreatintermittentstereotypicepisodesoffrequentseizureactivitypharmacologyandclinicalroleacomprehensivereview |