Development of Multimorbidity Indexes Based on Common Mental Health Conditions

Development of Multimorbidity Indexes Based on Common Mental Health Conditions

ObjectivesNumerous multimorbidity indexes exist, focused primarily or solely on somatic conditions. We developed mental multimorbidity indexes as epidemiological tools.MethodsParticipants in the French NutriNet-Santé cohort (73.5% women; mean age = 59.5 ± 13.7 years; index development N = 20,000; in...

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Main Authors: Junko Kose, Emmanuelle Kesse-Guyot, Pauline Duquenne, Serge Hercberg, Pilar Galan, Mathilde Touvier, Valentina A. Andreeva, Léopold K. Fezeu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:International Journal of Public Health
Subjects:
mental disorder comorbidity
mental health
multimorbidity index
epidemiological research tool
public health
Online Access:https://www.ssph-journal.org/articles/10.3389/ijph.2025.1607952/full
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Summary:ObjectivesNumerous multimorbidity indexes exist, focused primarily or solely on somatic conditions. We developed mental multimorbidity indexes as epidemiological tools.MethodsParticipants in the French NutriNet-Santé cohort (73.5% women; mean age = 59.5 ± 13.7 years; index development N = 20,000; index comparison N = 7,259) completed self-report questionnaires (2020–2022) regarding depressive symptoms, anxiety, eating disorders, insomnia, alcohol use disorders, cognitive difficulties, and the WHO Disability Assessment Schedule 2.0 (WHODAS 2.0). Using established cutoffs, participants were split into 2 groups for each condition. Tweedie regression analyses were performed with the 6 mental health conditions as exposures and the WHODAS 2.0 score as the outcome. Performance (C-index) and calibration of the indexes were compared with a simple count.ResultsA general and a sex-specific mental multimorbidity indexes were developed; both were significantly associated with the disability score. The new indexes had slightly better predictive performance than simple counts of mental disorders.ConclusionWe developed mental multimorbidity indexes as epidemiological research tools. Future prospective studies could investigate their predictive potential regarding outcomes such as medication use, healthcare utilization, and quality of life.
ISSN:1661-8564

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