Reviewing the current treatment approaches for bullous pemphigoid – analysis of literature
Bullous pemphigoid (BP) is an autoimmune blistering disorder primarily affecting the elderly, particularly older men, and is characterized by type 2 inflammation. The disease is defined by autoantibodies targeting BP180 (BPAG2) and BP230 (BPAG1) within the basement membrane zone. Advanced age is a...
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Kazimierz Wielki University
2025-02-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/57666 |
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| author | Julia Nowak Agnieszka Najdek Daria Oleksy Dawid Komada Urszula Kaczmarska Aleksandra Woźniak Michał Jakub Cioch Marcin Mycyk Kamil Hermanowicz Katarzyna Doman |
| author_facet | Julia Nowak Agnieszka Najdek Daria Oleksy Dawid Komada Urszula Kaczmarska Aleksandra Woźniak Michał Jakub Cioch Marcin Mycyk Kamil Hermanowicz Katarzyna Doman |
| author_sort | Julia Nowak |
| collection | DOAJ |
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Bullous pemphigoid (BP) is an autoimmune blistering disorder primarily affecting the elderly, particularly older men, and is characterized by type 2 inflammation. The disease is defined by autoantibodies targeting BP180 (BPAG2) and BP230 (BPAG1) within the basement membrane zone. Advanced age is a significant risk factor for BP, with additional associations identified, including certain medications—such as dipeptidyl peptidase-4 inhibitors and aldosterone antagonists—and neurological disorders like Parkinson’s disease. The global annual cumulative incidence of BP is estimated at 8.2 cases per 1,000,000 individuals, with Europe reporting higher incidence rates than other regions. BP significantly impacts patients’ quality of life due to painful, pruritic skin lesions and is associated with a higher prevalence of psychiatric comorbidities, such as schizophrenia. BP increases the risk of complications, including pulmonary embolism and pneumonia, and is linked to high mortality. These findings highlight the need for early diagnosis and comprehensive management to improve patient outcomes.
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| format | Article |
| id | doaj-art-cc2189a03cb446f4bf844146c7f42540 |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-cc2189a03cb446f4bf844146c7f425402025-02-12T08:17:49ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-02-017810.12775/JEHS.2025.78.57666Reviewing the current treatment approaches for bullous pemphigoid – analysis of literatureJulia Nowak0https://orcid.org/0009-0009-5954-8138Agnieszka Najdek1https://orcid.org/0009-0000-1112-3864Daria Oleksy2https://orcid.org/0009-0004-4492-3752Dawid Komada3https://orcid.org/0009-0009-6015-8292Urszula Kaczmarska4https://orcid.org/0009-0007-2986-5760Aleksandra Woźniak5https://orcid.org/0009-0004-7769-9865Michał Jakub Cioch6https://orcid.org/0009-0007-1555-3336Marcin Mycyk7https://orcid.org/0009-0001-2553-3327Kamil Hermanowicz8https://orcid.org/0009-0007-0844-1424Katarzyna Doman9https://orcid.org/0009-0005-1022-490XRAW-MEDICA NZOZ, Słowackiego 68, 96-200 Rawa Mazowiecka, Poland Teaching Hospital No. 2 of the Medical University of Lodz, Żeromskiego Street 113 90-549 Lodz, Poland Przychodnia Zespołu Lekarzy Rodzinnych LEKMED s.c. Czerwonego Krzyża 2, 63-000 Środa Wielkopolska, Poland Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie, ul. Złotej Jesieni 1, 31-826 Kraków, Poland ZOZ Ropczyce 39-100 Ropczyce, ul. Ks. Kard. St. Wyszyńskiego 54, Poland Faculty of Medicine, Medical University of Lodz, al. Tadeusza Kościuszki 4, 90-419, Łódź, Poland Centrum Medyczne LUX MED al. Pokoju 1Piotr Pelcer Klinika Zdrowia Sp. z o.o. Filia Kębłowo, ul. Chłopska 13, 84-242 Kębłowo, Poland SPZOZ w Zelowie, Żeromskiego 21, 97-425 Zelów, Poland NZOZ MEDICUS ,ul. Opiesińska 10-12, 98-220 Zduńska Wola, Poland Bullous pemphigoid (BP) is an autoimmune blistering disorder primarily affecting the elderly, particularly older men, and is characterized by type 2 inflammation. The disease is defined by autoantibodies targeting BP180 (BPAG2) and BP230 (BPAG1) within the basement membrane zone. Advanced age is a significant risk factor for BP, with additional associations identified, including certain medications—such as dipeptidyl peptidase-4 inhibitors and aldosterone antagonists—and neurological disorders like Parkinson’s disease. The global annual cumulative incidence of BP is estimated at 8.2 cases per 1,000,000 individuals, with Europe reporting higher incidence rates than other regions. BP significantly impacts patients’ quality of life due to painful, pruritic skin lesions and is associated with a higher prevalence of psychiatric comorbidities, such as schizophrenia. BP increases the risk of complications, including pulmonary embolism and pneumonia, and is linked to high mortality. These findings highlight the need for early diagnosis and comprehensive management to improve patient outcomes. https://apcz.umk.pl/JEHS/article/view/57666Bullous pemphigoidautoimmune blistering diseasecorticosteroids therapy |
| spellingShingle | Julia Nowak Agnieszka Najdek Daria Oleksy Dawid Komada Urszula Kaczmarska Aleksandra Woźniak Michał Jakub Cioch Marcin Mycyk Kamil Hermanowicz Katarzyna Doman Reviewing the current treatment approaches for bullous pemphigoid – analysis of literature Journal of Education, Health and Sport Bullous pemphigoid autoimmune blistering disease corticosteroids therapy |
| title | Reviewing the current treatment approaches for bullous pemphigoid – analysis of literature |
| title_full | Reviewing the current treatment approaches for bullous pemphigoid – analysis of literature |
| title_fullStr | Reviewing the current treatment approaches for bullous pemphigoid – analysis of literature |
| title_full_unstemmed | Reviewing the current treatment approaches for bullous pemphigoid – analysis of literature |
| title_short | Reviewing the current treatment approaches for bullous pemphigoid – analysis of literature |
| title_sort | reviewing the current treatment approaches for bullous pemphigoid analysis of literature |
| topic | Bullous pemphigoid autoimmune blistering disease corticosteroids therapy |
| url | https://apcz.umk.pl/JEHS/article/view/57666 |
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