Unlocking the potential of Rosmarinic acid: A review on extraction, isolation, quantification, pharmacokinetics and pharmacology
Background: Rosmarinic acid (RA) is a polyphenol abundantly found in culinary herbs like Rosemary, sage, perilla, and Tulsi, and it has varied therapeutic potential. It is an ester of caffeic acid and 3,4—di hydroxyphenyl lactic acid. It's been used as a food supplement and in traditional medic...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031324002008 |
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| author | Haritha Harindranath Aishwarya Susil Rajeshwari S Mahendran Sekar B.R. Prashantha Kumar |
| author_facet | Haritha Harindranath Aishwarya Susil Rajeshwari S Mahendran Sekar B.R. Prashantha Kumar |
| author_sort | Haritha Harindranath |
| collection | DOAJ |
| description | Background: Rosmarinic acid (RA) is a polyphenol abundantly found in culinary herbs like Rosemary, sage, perilla, and Tulsi, and it has varied therapeutic potential. It is an ester of caffeic acid and 3,4—di hydroxyphenyl lactic acid. It's been used as a food supplement and in traditional medicines since immemorial. Objectives: To review RA's properties, sources, extraction methods, chemical structure, bioavailability, and diverse therapeutic applications such as antioxidant, anti-inflammatory, anticancer, neuroprotective, cardioprotective, and antimicrobial properties. Methods: A systematic data review was carried out focussing on literature from 2004 – 2024 in online databases from Google Scholar, PubMed, ScienceDirect, Web of Science, Researchgate, and Scopus. The articles were searched using “Rosmarinic acid”, “Cancer”, “in silico”, “in vivo”, “in vitro”, “diabetes”, and “therapeutic” as the keywords. Conclusion: This review provides deep insights into the research works carried out on RA's potential as a medicinal source. Advancement from normal traditional usage to modern-day therapeutic practices, RA has come a long way to help mankind with its unique characteristics. From anti-bacterial to anti-cancer remedies RA has proven its healing properties and still provides a scope to explore further. |
| format | Article |
| id | doaj-art-cc3f0214598347c7b97e0e04e54fe54d |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-cc3f0214598347c7b97e0e04e54fe54d2025-02-10T04:35:19ZengElsevierPhytomedicine Plus2667-03132025-02-0151100726Unlocking the potential of Rosmarinic acid: A review on extraction, isolation, quantification, pharmacokinetics and pharmacologyHaritha Harindranath0Aishwarya Susil1Rajeshwari S2Mahendran Sekar3B.R. Prashantha Kumar4Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru 570 015, Karnataka, IndiaDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru 570 015, Karnataka, IndiaDepartment of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru 570 015, Karnataka, India.School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya 47500, Selangor, MalaysiaDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru 570 015, Karnataka, India; Corresponding author.Background: Rosmarinic acid (RA) is a polyphenol abundantly found in culinary herbs like Rosemary, sage, perilla, and Tulsi, and it has varied therapeutic potential. It is an ester of caffeic acid and 3,4—di hydroxyphenyl lactic acid. It's been used as a food supplement and in traditional medicines since immemorial. Objectives: To review RA's properties, sources, extraction methods, chemical structure, bioavailability, and diverse therapeutic applications such as antioxidant, anti-inflammatory, anticancer, neuroprotective, cardioprotective, and antimicrobial properties. Methods: A systematic data review was carried out focussing on literature from 2004 – 2024 in online databases from Google Scholar, PubMed, ScienceDirect, Web of Science, Researchgate, and Scopus. The articles were searched using “Rosmarinic acid”, “Cancer”, “in silico”, “in vivo”, “in vitro”, “diabetes”, and “therapeutic” as the keywords. Conclusion: This review provides deep insights into the research works carried out on RA's potential as a medicinal source. Advancement from normal traditional usage to modern-day therapeutic practices, RA has come a long way to help mankind with its unique characteristics. From anti-bacterial to anti-cancer remedies RA has proven its healing properties and still provides a scope to explore further.http://www.sciencedirect.com/science/article/pii/S2667031324002008Rosmarinic acidPolyphenolpharmacokineticsPharmacologyBioavailability |
| spellingShingle | Haritha Harindranath Aishwarya Susil Rajeshwari S Mahendran Sekar B.R. Prashantha Kumar Unlocking the potential of Rosmarinic acid: A review on extraction, isolation, quantification, pharmacokinetics and pharmacology Phytomedicine Plus Rosmarinic acid Polyphenol pharmacokinetics Pharmacology Bioavailability |
| title | Unlocking the potential of Rosmarinic acid: A review on extraction, isolation, quantification, pharmacokinetics and pharmacology |
| title_full | Unlocking the potential of Rosmarinic acid: A review on extraction, isolation, quantification, pharmacokinetics and pharmacology |
| title_fullStr | Unlocking the potential of Rosmarinic acid: A review on extraction, isolation, quantification, pharmacokinetics and pharmacology |
| title_full_unstemmed | Unlocking the potential of Rosmarinic acid: A review on extraction, isolation, quantification, pharmacokinetics and pharmacology |
| title_short | Unlocking the potential of Rosmarinic acid: A review on extraction, isolation, quantification, pharmacokinetics and pharmacology |
| title_sort | unlocking the potential of rosmarinic acid a review on extraction isolation quantification pharmacokinetics and pharmacology |
| topic | Rosmarinic acid Polyphenol pharmacokinetics Pharmacology Bioavailability |
| url | http://www.sciencedirect.com/science/article/pii/S2667031324002008 |
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