Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio associated with disease activity in patients with Takayasu’s arteritis: a case-control study
Background Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been reported to reflect the inflammatory response and disease activity in a variety of autoimmune diseases.Objectives This study aimed to evaluate the value of PLR and NLR as markers to monitor disease activ...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2017-05-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/7/4/e014451.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823857309337518080 |
|---|---|
| author | Juan Du Lili Pan Taotao Li Hua Liao |
| author_facet | Juan Du Lili Pan Taotao Li Hua Liao |
| author_sort | Juan Du |
| collection | DOAJ |
| description | Background Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been reported to reflect the inflammatory response and disease activity in a variety of autoimmune diseases.Objectives This study aimed to evaluate the value of PLR and NLR as markers to monitor disease activity in Takayasu’s arteritis (TAK).Methods A retrospective case–control study involving 88 patients with TAK and 78 healthy controls was performed. We compared the PLR and NLR between patients and healthy controls, and also analysed the correlations between PLR or NLR and indices of TAK disease activity.Results Increased PLR and NLR were observed in patients with TAK. PLR was positively correlated with hs-C-reactive protein (hs-CRP) (r=0.239, p=0.010) and erythrocyte sedimentation rate (ESR) (r=0.270, p=0.010). NLR also exhibited a positive relationship with Kerr’s score (r=0.284, p=0.002), hs-CRP (r=0.313, p=0.006) and ESR (r=0.249, p=0.019). A PLR level of 183.39 was shown to be the predictive cut-off value for TAK (sensitivity 37.8%, specificity 93.0%, area under the curve (AUC)=0.691). A NLR level of 2.417 was found to be the predictive cut-off value for TAK (sensitivity 75.6%, specificity 55.8%, AUC=0.697).Conclusions PLR and NLR could be useful markers to reflect inflammation and disease activity in patients with TAK. |
| format | Article |
| id | doaj-art-ccb2b5c0d97d4d56832935a8ea0aee3b |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-ccb2b5c0d97d4d56832935a8ea0aee3b2025-02-11T22:15:10ZengBMJ Publishing GroupBMJ Open2044-60552017-05-017410.1136/bmjopen-2016-014451Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio associated with disease activity in patients with Takayasu’s arteritis: a case-control studyJuan Du0Lili Pan1Taotao Li2Hua Liao3Department of Child Health Care, Beijing Children`s Hospital, Capital Medical University, National Center for Children`s Health, Beijing, ChinaDepartments of Rheumatology and Immunology, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaSection of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, SwedenDepartments of Rheumatology and Immunology, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaBackground Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have been reported to reflect the inflammatory response and disease activity in a variety of autoimmune diseases.Objectives This study aimed to evaluate the value of PLR and NLR as markers to monitor disease activity in Takayasu’s arteritis (TAK).Methods A retrospective case–control study involving 88 patients with TAK and 78 healthy controls was performed. We compared the PLR and NLR between patients and healthy controls, and also analysed the correlations between PLR or NLR and indices of TAK disease activity.Results Increased PLR and NLR were observed in patients with TAK. PLR was positively correlated with hs-C-reactive protein (hs-CRP) (r=0.239, p=0.010) and erythrocyte sedimentation rate (ESR) (r=0.270, p=0.010). NLR also exhibited a positive relationship with Kerr’s score (r=0.284, p=0.002), hs-CRP (r=0.313, p=0.006) and ESR (r=0.249, p=0.019). A PLR level of 183.39 was shown to be the predictive cut-off value for TAK (sensitivity 37.8%, specificity 93.0%, area under the curve (AUC)=0.691). A NLR level of 2.417 was found to be the predictive cut-off value for TAK (sensitivity 75.6%, specificity 55.8%, AUC=0.697).Conclusions PLR and NLR could be useful markers to reflect inflammation and disease activity in patients with TAK.https://bmjopen.bmj.com/content/7/4/e014451.full |
| spellingShingle | Juan Du Lili Pan Taotao Li Hua Liao Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio associated with disease activity in patients with Takayasu’s arteritis: a case-control study BMJ Open |
| title | Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio associated with disease activity in patients with Takayasu’s arteritis: a case-control study |
| title_full | Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio associated with disease activity in patients with Takayasu’s arteritis: a case-control study |
| title_fullStr | Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio associated with disease activity in patients with Takayasu’s arteritis: a case-control study |
| title_full_unstemmed | Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio associated with disease activity in patients with Takayasu’s arteritis: a case-control study |
| title_short | Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio associated with disease activity in patients with Takayasu’s arteritis: a case-control study |
| title_sort | platelet to lymphocyte ratio and neutrophil to lymphocyte ratio associated with disease activity in patients with takayasu s arteritis a case control study |
| url | https://bmjopen.bmj.com/content/7/4/e014451.full |
| work_keys_str_mv | AT juandu platelettolymphocyteratioandneutrophiltolymphocyteratioassociatedwithdiseaseactivityinpatientswithtakayasusarteritisacasecontrolstudy AT lilipan platelettolymphocyteratioandneutrophiltolymphocyteratioassociatedwithdiseaseactivityinpatientswithtakayasusarteritisacasecontrolstudy AT taotaoli platelettolymphocyteratioandneutrophiltolymphocyteratioassociatedwithdiseaseactivityinpatientswithtakayasusarteritisacasecontrolstudy AT hualiao platelettolymphocyteratioandneutrophiltolymphocyteratioassociatedwithdiseaseactivityinpatientswithtakayasusarteritisacasecontrolstudy |