Characteristics of plastic bronchitis in children with infectious pneumonia
Abstract Background Multiple studies have reported that infectious pneumonia can induce the production of plastic casts, which threatens children's health. We explored the characteristics of plastic bronchitis (PB) in clinical practice by analysing clinical medical records. Methods A retrospect...
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| Language: | English |
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BMC
2025-02-01
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| Series: | Italian Journal of Pediatrics |
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| Online Access: | https://doi.org/10.1186/s13052-025-01873-4 |
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| author | Xulong Cai Mali Lin Li Zhou Wencai Sheng Wanyan Jiao Hongliang Bian Tongjin Yin |
| author_facet | Xulong Cai Mali Lin Li Zhou Wencai Sheng Wanyan Jiao Hongliang Bian Tongjin Yin |
| author_sort | Xulong Cai |
| collection | DOAJ |
| description | Abstract Background Multiple studies have reported that infectious pneumonia can induce the production of plastic casts, which threatens children's health. We explored the characteristics of plastic bronchitis (PB) in clinical practice by analysing clinical medical records. Methods A retrospective study was conducted. Children with pneumonia and large chest shadows were included in this study. The differences in characteristics between patients with plastic bronchitis and those without plastic bronchitis were analysed. The distribution of pathogens was statistically analysed. Grouping analysis based on PB and pathogen conditions was also conducted. Results A total of 185 patients were included in this study. The patients were divided into two groups: the PB group (n = 48) and the non-PB group (n = 137). The duration of illness before hospitalization in the PB group was mostly longer than that in the non-PB group. The frequency distribution of the inspiratory three concave signs in the PB group was significantly greater than that in the non-PB group. Compared with those in the non-PB group, the number of patients with abnormally elevated of D-D dimer, LDH, ALT, and AST in the PB group was significantly greater. Mycoplasma pneumoniae (MP) was the main pathogen observed in both the PB and non-PB groups. In cases of MP infection without plastic bronchitis, treatment with macrolide antibiotics occurred significantly earlier. Most cases of pleural effusion in the PB-MP group were discovered more than 7 days after onset. However, in the PB-nonMP group, most cases of pleural effusion were detected within 7 days of onset. There was a difference observed in the distribution of pulmonary necrosis between the PB group and the non-PB group. Conclusions MP is a common pathogen observed in PB cases caused by single-pathogen infections and multiple-pathogen infections. PB may be a potential cause of pulmonary necrosis. Furthermore, PB exhibits diverse clinical manifestations due to host and pathogen factors. |
| format | Article |
| id | doaj-art-cce2d846c91b4d7db2220069259e6bd3 |
| institution | Kabale University |
| issn | 1824-7288 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj-art-cce2d846c91b4d7db2220069259e6bd32025-02-09T12:48:07ZengBMCItalian Journal of Pediatrics1824-72882025-02-0151111110.1186/s13052-025-01873-4Characteristics of plastic bronchitis in children with infectious pneumoniaXulong Cai0Mali Lin1Li Zhou2Wencai Sheng3Wanyan Jiao4Hongliang Bian5Tongjin Yin6Department of Pediatrics, Affiliated Hospital 6 of Nantong UniversityDepartment of Pediatrics, Jinhua Maternal & Child Health Care HospitalDepartment of Pediatrics, Affiliated Hospital 6 of Nantong UniversityDepartment of Pediatrics, Affiliated Hospital 6 of Nantong UniversityDepartment of Pediatrics, Affiliated Hospital 6 of Nantong UniversityDepartment of Pediatrics, Affiliated Hospital 6 of Nantong UniversityDepartment of Pediatrics, Affiliated Hospital 6 of Nantong UniversityAbstract Background Multiple studies have reported that infectious pneumonia can induce the production of plastic casts, which threatens children's health. We explored the characteristics of plastic bronchitis (PB) in clinical practice by analysing clinical medical records. Methods A retrospective study was conducted. Children with pneumonia and large chest shadows were included in this study. The differences in characteristics between patients with plastic bronchitis and those without plastic bronchitis were analysed. The distribution of pathogens was statistically analysed. Grouping analysis based on PB and pathogen conditions was also conducted. Results A total of 185 patients were included in this study. The patients were divided into two groups: the PB group (n = 48) and the non-PB group (n = 137). The duration of illness before hospitalization in the PB group was mostly longer than that in the non-PB group. The frequency distribution of the inspiratory three concave signs in the PB group was significantly greater than that in the non-PB group. Compared with those in the non-PB group, the number of patients with abnormally elevated of D-D dimer, LDH, ALT, and AST in the PB group was significantly greater. Mycoplasma pneumoniae (MP) was the main pathogen observed in both the PB and non-PB groups. In cases of MP infection without plastic bronchitis, treatment with macrolide antibiotics occurred significantly earlier. Most cases of pleural effusion in the PB-MP group were discovered more than 7 days after onset. However, in the PB-nonMP group, most cases of pleural effusion were detected within 7 days of onset. There was a difference observed in the distribution of pulmonary necrosis between the PB group and the non-PB group. Conclusions MP is a common pathogen observed in PB cases caused by single-pathogen infections and multiple-pathogen infections. PB may be a potential cause of pulmonary necrosis. Furthermore, PB exhibits diverse clinical manifestations due to host and pathogen factors.https://doi.org/10.1186/s13052-025-01873-4Plastic bronchitisInfectious pneumoniaClinical manifestationsChildren |
| spellingShingle | Xulong Cai Mali Lin Li Zhou Wencai Sheng Wanyan Jiao Hongliang Bian Tongjin Yin Characteristics of plastic bronchitis in children with infectious pneumonia Italian Journal of Pediatrics Plastic bronchitis Infectious pneumonia Clinical manifestations Children |
| title | Characteristics of plastic bronchitis in children with infectious pneumonia |
| title_full | Characteristics of plastic bronchitis in children with infectious pneumonia |
| title_fullStr | Characteristics of plastic bronchitis in children with infectious pneumonia |
| title_full_unstemmed | Characteristics of plastic bronchitis in children with infectious pneumonia |
| title_short | Characteristics of plastic bronchitis in children with infectious pneumonia |
| title_sort | characteristics of plastic bronchitis in children with infectious pneumonia |
| topic | Plastic bronchitis Infectious pneumonia Clinical manifestations Children |
| url | https://doi.org/10.1186/s13052-025-01873-4 |
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