Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning
Background/Aims: Liver transplantation is a life-saving approach in some cases of mushroom poisoning, which is one of the important causes of acute liver failure. However, debate continues regarding the timing of liver transplantation. The aim of this study is to retrospectively evaluate the results...
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| Format: | Article |
| Language: | English |
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AVES
2025-02-01
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| Series: | The Turkish Journal of Gastroenterology |
| Online Access: | https://www.turkjgastroenterol.org/en/liver-transplantation-for-acute-liver-failure-due-to-mushroom-poisoning-137289 |
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| author | Hayri Canbaz Attila Bestemir Sami Akbulut Sezai Yilmaz Yusuf Yavuz |
| author_facet | Hayri Canbaz Attila Bestemir Sami Akbulut Sezai Yilmaz Yusuf Yavuz |
| author_sort | Hayri Canbaz |
| collection | DOAJ |
| description | Background/Aims: Liver transplantation is a life-saving approach in some cases of mushroom poisoning, which is one of the important causes of acute liver failure. However, debate continues regarding the timing of liver transplantation. The aim of this study is to retrospectively evaluate the results of patients who underwent liver transplantation due to mushroom poisoning.
Materials and Methods: In this descriptive and observational study, the demographic and clinical data of 26 patients who presented to emergency units due to clinical features of acute hepatic failure secondary to mushroom poisoning between October 2008 and November 2023 and who underwent emergent liver transplantation were retrospectively reviewed.
Results: A total of 26 patients with a median (IQR) age of 39 (36) years were included in this study. The patients were divided into two groups: alive (n = 18) and dead (n = 8). No statistically significant differences were found between groups in terms of age, BMI, blood groups, hepatic encephalopathy grade, biochemical analysis obtained on the first days of hospital admission (AST, ALT, creatinine, ammonia, PTT, INR, albumin, platelets, HGB), ICU stay, cold ischemia time (CIT) and warm ischemia time (WIT), total bilirubin (P = .052), and time from poisoning to admission (P = .051). On the other hand, there were statistically significant differences between the alive and dead groups in terms of MELD score (P = .016; 23 vs. 34), re-transplantation (P = .022; 0% vs. 37.5%), hospital stay (P = .004; 24 vs. 6 days), and follow up (P < .001; 3423 vs. 5 days).
Conclusions: This study showed that mortality was higher in patients with high MELD scores and patients who underwent re-transplantation. However, this study needs to be supported by multicenter prospective studies. |
| format | Article |
| id | doaj-art-cd0ebf5b67e744469a2bda29c5ccc5c4 |
| institution | Kabale University |
| issn | 2148-5607 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | AVES |
| record_format | Article |
| series | The Turkish Journal of Gastroenterology |
| spelling | doaj-art-cd0ebf5b67e744469a2bda29c5ccc5c42025-02-11T13:40:58ZengAVESThe Turkish Journal of Gastroenterology2148-56072025-02-0136210711310.5152/tjg.2024.24226Liver Transplantation for Acute Liver Failure due to Mushroom PoisoningHayri Canbaz0https://orcid.org/0000-0001-6989-7854Attila Bestemir1https://orcid.org/0000-0003-0986-9039Sami Akbulut2https://orcid.org/0000-0002-6864-7711Sezai Yilmaz3https://orcid.org/0000-0002-8044-0297Yusuf Yavuz4https://orcid.org/0000-0001-8031-2992Department of Emergency Medicine, Yıldırım Beyazit University, Yenimahalle Training and Research Hospital, Ankara, TürkiyeDepartment of Private Health Institutions with Outpatient Diagnosis and Treatment, Ministry of Health, Ankara, TürkiyeDepartment of Surgery and Liver Transplant Institute, İnonu University Faculty of Medicine, Malatya, TürkiyeDepartment of Surgery and Liver Transplant Institute, İnonu University Faculty of Medicine, Malatya, TürkiyeDepartment of General Surgery, Necmettin Erbakan Universitesi Meram Faculty of Medicine, Konya, TürkiyeBackground/Aims: Liver transplantation is a life-saving approach in some cases of mushroom poisoning, which is one of the important causes of acute liver failure. However, debate continues regarding the timing of liver transplantation. The aim of this study is to retrospectively evaluate the results of patients who underwent liver transplantation due to mushroom poisoning. Materials and Methods: In this descriptive and observational study, the demographic and clinical data of 26 patients who presented to emergency units due to clinical features of acute hepatic failure secondary to mushroom poisoning between October 2008 and November 2023 and who underwent emergent liver transplantation were retrospectively reviewed. Results: A total of 26 patients with a median (IQR) age of 39 (36) years were included in this study. The patients were divided into two groups: alive (n = 18) and dead (n = 8). No statistically significant differences were found between groups in terms of age, BMI, blood groups, hepatic encephalopathy grade, biochemical analysis obtained on the first days of hospital admission (AST, ALT, creatinine, ammonia, PTT, INR, albumin, platelets, HGB), ICU stay, cold ischemia time (CIT) and warm ischemia time (WIT), total bilirubin (P = .052), and time from poisoning to admission (P = .051). On the other hand, there were statistically significant differences between the alive and dead groups in terms of MELD score (P = .016; 23 vs. 34), re-transplantation (P = .022; 0% vs. 37.5%), hospital stay (P = .004; 24 vs. 6 days), and follow up (P < .001; 3423 vs. 5 days). Conclusions: This study showed that mortality was higher in patients with high MELD scores and patients who underwent re-transplantation. However, this study needs to be supported by multicenter prospective studies.https://www.turkjgastroenterol.org/en/liver-transplantation-for-acute-liver-failure-due-to-mushroom-poisoning-137289 |
| spellingShingle | Hayri Canbaz Attila Bestemir Sami Akbulut Sezai Yilmaz Yusuf Yavuz Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning The Turkish Journal of Gastroenterology |
| title | Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning |
| title_full | Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning |
| title_fullStr | Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning |
| title_full_unstemmed | Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning |
| title_short | Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning |
| title_sort | liver transplantation for acute liver failure due to mushroom poisoning |
| url | https://www.turkjgastroenterol.org/en/liver-transplantation-for-acute-liver-failure-due-to-mushroom-poisoning-137289 |
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