Expression of atherosclerosis-associated genes in peripheral blood of drug-naïve hypertensive subjects with newly-diagnosed type 2 diabetes mellitus
Aim: To evaluate the expression of atherosclerosis-associated genes in peripheral blood of drug-naïve hypertensive subjects with newly-diagnosed type 2 diabetes mellitus. Materials and methods: Eighteen subjects (15 males, 3 females), mean age 46.27 ± 12.07 years, divided into two groups:...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pensoft Publishers
2025-02-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/141312/download/pdf/ |
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| Summary: | Aim: To evaluate the expression of atherosclerosis-associated genes in peripheral blood of drug-naïve hypertensive subjects with newly-diagnosed type 2 diabetes mellitus. Materials and methods: Eighteen subjects (15 males, 3 females), mean age 46.27 ± 12.07 years, divided into two groups: studied group - subjects with newly-diagnosed hypertension and newly-diagnosed type 2 diabetes (n = 9), control group – normotensive individuals with newly-diagnosed type 2 diabetes (n = 9) Gene expression analysis was performed with Human Atherosclerosis RT2 Profiler PCR Array. Results: In gene expression analysis, 5 genes with increased expression in the studied group were found – CD44, ITGA5, ITGB2, PPARA and RXRA. No genes with decreased expression matching the criteria were found. Conclusion: The presence of arterial hypertension in subjects with newly diagnosed type 2 diabetes tends to increase the expression of CD44, ITGA5, ITGB2, PPARA and RXRA in the peripheral blood. |
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| ISSN: | 2603-557X |