Expression of atherosclerosis-associated genes in peripheral blood of drug-naïve hypertensive subjects with newly-diagnosed type 2 diabetes mellitus
Aim: To evaluate the expression of atherosclerosis-associated genes in peripheral blood of drug-naïve hypertensive subjects with newly-diagnosed type 2 diabetes mellitus. Materials and methods: Eighteen subjects (15 males, 3 females), mean age 46.27 ± 12.07 years, divided into two groups:...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2025-02-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/141312/download/pdf/ |
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| author | Nikolay Stoynev Ivanka Dimova Blaga Rukova Savina Hadjidekova Dragomira Nikolova Tsvetalina Tankova |
| author_facet | Nikolay Stoynev Ivanka Dimova Blaga Rukova Savina Hadjidekova Dragomira Nikolova Tsvetalina Tankova |
| author_sort | Nikolay Stoynev |
| collection | DOAJ |
| description | Aim: To evaluate the expression of atherosclerosis-associated genes in peripheral blood of drug-naïve hypertensive subjects with newly-diagnosed type 2 diabetes mellitus. Materials and methods: Eighteen subjects (15 males, 3 females), mean age 46.27 ± 12.07 years, divided into two groups: studied group - subjects with newly-diagnosed hypertension and newly-diagnosed type 2 diabetes (n = 9), control group – normotensive individuals with newly-diagnosed type 2 diabetes (n = 9) Gene expression analysis was performed with Human Atherosclerosis RT2 Profiler PCR Array. Results: In gene expression analysis, 5 genes with increased expression in the studied group were found – CD44, ITGA5, ITGB2, PPARA and RXRA. No genes with decreased expression matching the criteria were found. Conclusion: The presence of arterial hypertension in subjects with newly diagnosed type 2 diabetes tends to increase the expression of CD44, ITGA5, ITGB2, PPARA and RXRA in the peripheral blood. |
| format | Article |
| id | doaj-art-cd8fcd0304364c9ca164e4574fd8e202 |
| institution | Kabale University |
| issn | 2603-557X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj-art-cd8fcd0304364c9ca164e4574fd8e2022025-02-12T08:31:49ZengPensoft PublishersPharmacia2603-557X2025-02-01721610.3897/pharmacia.72.e141312141312Expression of atherosclerosis-associated genes in peripheral blood of drug-naïve hypertensive subjects with newly-diagnosed type 2 diabetes mellitusNikolay Stoynev0Ivanka Dimova1Blaga Rukova2Savina Hadjidekova3Dragomira Nikolova4Tsvetalina Tankova5Medical University SofiaMedical University SofiaMedical University SofiaMedical University SofiaMedical University SofiaMedical University SofiaAim: To evaluate the expression of atherosclerosis-associated genes in peripheral blood of drug-naïve hypertensive subjects with newly-diagnosed type 2 diabetes mellitus. Materials and methods: Eighteen subjects (15 males, 3 females), mean age 46.27 ± 12.07 years, divided into two groups: studied group - subjects with newly-diagnosed hypertension and newly-diagnosed type 2 diabetes (n = 9), control group – normotensive individuals with newly-diagnosed type 2 diabetes (n = 9) Gene expression analysis was performed with Human Atherosclerosis RT2 Profiler PCR Array. Results: In gene expression analysis, 5 genes with increased expression in the studied group were found – CD44, ITGA5, ITGB2, PPARA and RXRA. No genes with decreased expression matching the criteria were found. Conclusion: The presence of arterial hypertension in subjects with newly diagnosed type 2 diabetes tends to increase the expression of CD44, ITGA5, ITGB2, PPARA and RXRA in the peripheral blood.https://pharmacia.pensoft.net/article/141312/download/pdf/ |
| spellingShingle | Nikolay Stoynev Ivanka Dimova Blaga Rukova Savina Hadjidekova Dragomira Nikolova Tsvetalina Tankova Expression of atherosclerosis-associated genes in peripheral blood of drug-naïve hypertensive subjects with newly-diagnosed type 2 diabetes mellitus Pharmacia |
| title | Expression of atherosclerosis-associated genes in peripheral blood of drug-naïve hypertensive subjects with newly-diagnosed type 2 diabetes mellitus |
| title_full | Expression of atherosclerosis-associated genes in peripheral blood of drug-naïve hypertensive subjects with newly-diagnosed type 2 diabetes mellitus |
| title_fullStr | Expression of atherosclerosis-associated genes in peripheral blood of drug-naïve hypertensive subjects with newly-diagnosed type 2 diabetes mellitus |
| title_full_unstemmed | Expression of atherosclerosis-associated genes in peripheral blood of drug-naïve hypertensive subjects with newly-diagnosed type 2 diabetes mellitus |
| title_short | Expression of atherosclerosis-associated genes in peripheral blood of drug-naïve hypertensive subjects with newly-diagnosed type 2 diabetes mellitus |
| title_sort | expression of atherosclerosis associated genes in peripheral blood of drug naive hypertensive subjects with newly diagnosed type 2 diabetes mellitus |
| url | https://pharmacia.pensoft.net/article/141312/download/pdf/ |
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