First-Trimester Threatened Abortion: Can Red Blood Cell Distribution Width-Standard Deviation Predict Miscarriage?
OBJECTIVE: The objective of the study was to investigate the predictive value of red blood cell distribution width-standard deviation (RDW-SD) and another complete blood count (CBC) derived blood markers in patients presenting with threatened abortion concerning miscarriage. STUDY DESIGN: This r...
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Medical Network
2024-12-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1489 |
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| author | Sebnem Karagun Yusuf Dal Hamza Yildiz Sefanur Gamze Karaca Ahmet Zeki Nessar Ayhan Coskun |
| author_facet | Sebnem Karagun Yusuf Dal Hamza Yildiz Sefanur Gamze Karaca Ahmet Zeki Nessar Ayhan Coskun |
| author_sort | Sebnem Karagun |
| collection | DOAJ |
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OBJECTIVE: The objective of the study was to investigate the predictive value of red blood cell distribution width-standard deviation (RDW-SD) and another complete blood count (CBC) derived blood markers in patients presenting with threatened abortion concerning miscarriage.
STUDY DESIGN: This retrospective cross-sectional study included a cohort of 222 women with threatened abortion in the first trimester. The study group consisted of 114 patients who underwent miscarriage, and the control group included 108 pregnant women who delivered at term. The prognostic potential of RDW-SD and other CBC indices, readily obtainable from blood counts at the presentation of threatened abortion, was examined in the context of miscarriage development. The predictive value was calculated using the Receiver Operating Characteristic (ROC) curve.
RESULTS: The analysis revealed a statistically significant decline in RDW-SD within the miscarriage cohort compared to the control group. Notably, no statistically significant differences were identified in the neutrophil-lymphocyte ratio (NLR), derived NLR (DNLR), systemic inflammatory immune index (SII), platelet-to-lymphocyte ratio (PLR), and delta neutrophil index (DNI).
CONCLUSION: In this study, we found that RDW-SD, as a novel inflammatory mediator may be a useful marker for miscarriage in first trimester bleeding. However, it should be noted that traditional CBC indices, including NLR, DNLR, SII, PLR, and DNI, were found to be unsuitable indicators for miscarriage in threatened abortion.
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| format | Article |
| id | doaj-art-ce9bb646925f43a3a8ae6126d3b02c7a |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-ce9bb646925f43a3a8ae6126d3b02c7a2025-02-11T21:19:02ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182024-12-0130310.21613/GORM.2023.1489First-Trimester Threatened Abortion: Can Red Blood Cell Distribution Width-Standard Deviation Predict Miscarriage?Sebnem Karagun0Yusuf Dal1Hamza Yildiz2Sefanur Gamze Karaca3Ahmet Zeki Nessar4Ayhan Coskun5drDrDrDrDrDr OBJECTIVE: The objective of the study was to investigate the predictive value of red blood cell distribution width-standard deviation (RDW-SD) and another complete blood count (CBC) derived blood markers in patients presenting with threatened abortion concerning miscarriage. STUDY DESIGN: This retrospective cross-sectional study included a cohort of 222 women with threatened abortion in the first trimester. The study group consisted of 114 patients who underwent miscarriage, and the control group included 108 pregnant women who delivered at term. The prognostic potential of RDW-SD and other CBC indices, readily obtainable from blood counts at the presentation of threatened abortion, was examined in the context of miscarriage development. The predictive value was calculated using the Receiver Operating Characteristic (ROC) curve. RESULTS: The analysis revealed a statistically significant decline in RDW-SD within the miscarriage cohort compared to the control group. Notably, no statistically significant differences were identified in the neutrophil-lymphocyte ratio (NLR), derived NLR (DNLR), systemic inflammatory immune index (SII), platelet-to-lymphocyte ratio (PLR), and delta neutrophil index (DNI). CONCLUSION: In this study, we found that RDW-SD, as a novel inflammatory mediator may be a useful marker for miscarriage in first trimester bleeding. However, it should be noted that traditional CBC indices, including NLR, DNLR, SII, PLR, and DNI, were found to be unsuitable indicators for miscarriage in threatened abortion. https://gorm.com.tr/index.php/GORM/article/view/1489Complete blood count indices; Miscarriage; Rred blood cell distribution width-standard deviation; Threatened abortion |
| spellingShingle | Sebnem Karagun Yusuf Dal Hamza Yildiz Sefanur Gamze Karaca Ahmet Zeki Nessar Ayhan Coskun First-Trimester Threatened Abortion: Can Red Blood Cell Distribution Width-Standard Deviation Predict Miscarriage? Gynecology Obstetrics & Reproductive Medicine Complete blood count indices; Miscarriage; Rred blood cell distribution width-standard deviation; Threatened abortion |
| title | First-Trimester Threatened Abortion: Can Red Blood Cell Distribution Width-Standard Deviation Predict Miscarriage? |
| title_full | First-Trimester Threatened Abortion: Can Red Blood Cell Distribution Width-Standard Deviation Predict Miscarriage? |
| title_fullStr | First-Trimester Threatened Abortion: Can Red Blood Cell Distribution Width-Standard Deviation Predict Miscarriage? |
| title_full_unstemmed | First-Trimester Threatened Abortion: Can Red Blood Cell Distribution Width-Standard Deviation Predict Miscarriage? |
| title_short | First-Trimester Threatened Abortion: Can Red Blood Cell Distribution Width-Standard Deviation Predict Miscarriage? |
| title_sort | first trimester threatened abortion can red blood cell distribution width standard deviation predict miscarriage |
| topic | Complete blood count indices; Miscarriage; Rred blood cell distribution width-standard deviation; Threatened abortion |
| url | https://gorm.com.tr/index.php/GORM/article/view/1489 |
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