Hepatoprotective effects of propolis ethanol extract on D-galactose-induced aging mice: A metabolomics and transcriptomics analysis focusing on insulin resistance pathways
This study aimed to evaluate the hepatoprotective effects of Propolis ethanol extract (PEE) in D-galactose (D-gal)-induced senescence mice and explore its underlying mechanisms. Mice were administered PEE by gavage, and body weight, organ index, and serum biomarkers (SOD, MDA, AST, ALT) were measure...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000106 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | This study aimed to evaluate the hepatoprotective effects of Propolis ethanol extract (PEE) in D-galactose (D-gal)-induced senescence mice and explore its underlying mechanisms. Mice were administered PEE by gavage, and body weight, organ index, and serum biomarkers (SOD, MDA, AST, ALT) were measured. Liver histopathological changes were examined using HE staining. Additionally, transcriptomics and metabolomics analyses were employed to elucidate the molecular mechanisms. The results demonstrated that PEE ameliorated the reductions in body weight and liver index in aged mice. PEE significantly increased serum SOD levels and reduced MDA, AST, and ALT levels. Histological analysis revealed that PEE mitigated liver damage. Mechanistically, PEE appeared to exert hepatoprotective effects by modulating the insulin resistance pathway, particularly through the PI3K-AKT/PP1 signaling axis, thereby enhancing glycogen synthesis in the damaged liver. These findings provide a scientific foundation for the therapeutic potential of PEE in anti-aging and liver disease. |
|---|---|
| ISSN: | 1756-4646 |