Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases
Abstract Calcium signaling plays a pivotal role in diverse cellular processes through precise spatiotemporal regulation and interaction with effector proteins across distinct subcellular compartments. Mitochondria, in particular, act as central hubs for calcium buffering, orchestrating energy produc...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | npj Metabolic Health and Disease |
| Online Access: | https://doi.org/10.1038/s44324-025-00049-2 |
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| _version_ | 1823863307702894592 |
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| author | Fivos Borbolis Christina Ploumi Konstantinos Palikaras |
| author_facet | Fivos Borbolis Christina Ploumi Konstantinos Palikaras |
| author_sort | Fivos Borbolis |
| collection | DOAJ |
| description | Abstract Calcium signaling plays a pivotal role in diverse cellular processes through precise spatiotemporal regulation and interaction with effector proteins across distinct subcellular compartments. Mitochondria, in particular, act as central hubs for calcium buffering, orchestrating energy production, redox balance and apoptotic signaling, among others. While controlled mitochondrial calcium uptake supports ATP synthesis and metabolic regulation, excessive accumulation can trigger oxidative stress, mitochondrial membrane permeabilization, and cell death. Emerging findings underscore the intricate interplay between calcium homeostasis and mitophagy, a selective type of autophagy for mitochondria elimination. Although the literature is still emerging, this review delves into the bidirectional relationship between calcium signaling and mitophagy pathways, providing compelling mechanistic insights. Furthermore, we discuss how disruptions in calcium homeostasis impair mitophagy, contributing to mitochondrial dysfunction and the pathogenesis of common neurodegenerative diseases. |
| format | Article |
| id | doaj-art-d033f24050da403e8c6c71e55851af5a |
| institution | Kabale University |
| issn | 2948-2828 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Metabolic Health and Disease |
| spelling | doaj-art-d033f24050da403e8c6c71e55851af5a2025-02-09T12:11:55ZengNature Portfolionpj Metabolic Health and Disease2948-28282025-02-013111910.1038/s44324-025-00049-2Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseasesFivos Borbolis0Christina Ploumi1Konstantinos Palikaras2Department of Physiology, Medical School, National and Kapodistrian University of AthensDepartment of Physiology, Medical School, National and Kapodistrian University of AthensDepartment of Physiology, Medical School, National and Kapodistrian University of AthensAbstract Calcium signaling plays a pivotal role in diverse cellular processes through precise spatiotemporal regulation and interaction with effector proteins across distinct subcellular compartments. Mitochondria, in particular, act as central hubs for calcium buffering, orchestrating energy production, redox balance and apoptotic signaling, among others. While controlled mitochondrial calcium uptake supports ATP synthesis and metabolic regulation, excessive accumulation can trigger oxidative stress, mitochondrial membrane permeabilization, and cell death. Emerging findings underscore the intricate interplay between calcium homeostasis and mitophagy, a selective type of autophagy for mitochondria elimination. Although the literature is still emerging, this review delves into the bidirectional relationship between calcium signaling and mitophagy pathways, providing compelling mechanistic insights. Furthermore, we discuss how disruptions in calcium homeostasis impair mitophagy, contributing to mitochondrial dysfunction and the pathogenesis of common neurodegenerative diseases.https://doi.org/10.1038/s44324-025-00049-2 |
| spellingShingle | Fivos Borbolis Christina Ploumi Konstantinos Palikaras Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases npj Metabolic Health and Disease |
| title | Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases |
| title_full | Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases |
| title_fullStr | Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases |
| title_full_unstemmed | Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases |
| title_short | Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases |
| title_sort | calcium mediated regulation of mitophagy implications in neurodegenerative diseases |
| url | https://doi.org/10.1038/s44324-025-00049-2 |
| work_keys_str_mv | AT fivosborbolis calciummediatedregulationofmitophagyimplicationsinneurodegenerativediseases AT christinaploumi calciummediatedregulationofmitophagyimplicationsinneurodegenerativediseases AT konstantinospalikaras calciummediatedregulationofmitophagyimplicationsinneurodegenerativediseases |