The relationship between involutional ectropion and inflammatory disorders of the eyelids and ocular surface: insights from a large-scale national study
Abstract This study investigated potential associations between ectropion and various chronic and systemic inflammatory diseases affecting the eyelids and ocular surface. This retrospective case-control study, spanning 2001–2022, used electronic medical records from Clalit Health Services (CHS) in I...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-88138-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823862343863369728 |
|---|---|
| author | Ahmad Mansour Tomer Kerman Nir Amitai Eran Zunz Soltan Khalaila Itai Hazan Erez Tsumi |
| author_facet | Ahmad Mansour Tomer Kerman Nir Amitai Eran Zunz Soltan Khalaila Itai Hazan Erez Tsumi |
| author_sort | Ahmad Mansour |
| collection | DOAJ |
| description | Abstract This study investigated potential associations between ectropion and various chronic and systemic inflammatory diseases affecting the eyelids and ocular surface. This retrospective case-control study, spanning 2001–2022, used electronic medical records from Clalit Health Services (CHS) in Israel. Patients diagnosed with involutional ectropion served as the case group, while two control groups were used for comparison: one comprising patients diagnosed with senile cataract and the other with various ophthalmic diseases. Matching for the control groups was performed at a 1:3 ratio based on year of birth, sex, and ethnicity. A total of 17,292 patients with involutional ectropion and 51,876 matched controls in each group were included. The average age of the patients with involutional ectropion was 78 ± 10 years and 58% were men. Significant associations were found between involutional ectropion and several local inflammatory eyelid diseases: blepharitis (OR 4.66), chalazion (OR 2.94), hordeolum (OR 2.26), and dermatitis of the eyelid (OR 2.46). Ocular surface diseases associated with ectropion included chronic conjunctivitis (OR2.89 ) and pterygium (OR 2.48). Systemic diseases such as hypertension (OR 1.46), dyslipidemia (OR 1.45), and autoimmune rheumatic diseases (OR 1.43) were also associated with involutional ectropion. This study found that localized chronic inflammatory conditions affecting the periocular tissues and ocular surface are significantly associated with the development of involutional ectropion. |
| format | Article |
| id | doaj-art-d158bd6ce6c1445c9855e8b180597c8f |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-d158bd6ce6c1445c9855e8b180597c8f2025-02-09T12:33:33ZengNature PortfolioScientific Reports2045-23222025-02-011511810.1038/s41598-025-88138-6The relationship between involutional ectropion and inflammatory disorders of the eyelids and ocular surface: insights from a large-scale national studyAhmad Mansour0Tomer Kerman1Nir Amitai2Eran Zunz3Soltan Khalaila4Itai Hazan5Erez Tsumi6Department of Ophthalmology, Soroka Medical Center, Ben-Gurion University of the NegevClinical Research Center, Soroka Medical CenterClinical Research Center, Soroka Medical CenterDepartment of Ophthalmology, Soroka Medical Center, Ben-Gurion University of the NegevDepartment of Ophthalmology, Soroka Medical Center, Ben-Gurion University of the NegevClinical Research Center, Soroka Medical CenterDepartment of Ophthalmology, Soroka Medical Center, Ben-Gurion University of the NegevAbstract This study investigated potential associations between ectropion and various chronic and systemic inflammatory diseases affecting the eyelids and ocular surface. This retrospective case-control study, spanning 2001–2022, used electronic medical records from Clalit Health Services (CHS) in Israel. Patients diagnosed with involutional ectropion served as the case group, while two control groups were used for comparison: one comprising patients diagnosed with senile cataract and the other with various ophthalmic diseases. Matching for the control groups was performed at a 1:3 ratio based on year of birth, sex, and ethnicity. A total of 17,292 patients with involutional ectropion and 51,876 matched controls in each group were included. The average age of the patients with involutional ectropion was 78 ± 10 years and 58% were men. Significant associations were found between involutional ectropion and several local inflammatory eyelid diseases: blepharitis (OR 4.66), chalazion (OR 2.94), hordeolum (OR 2.26), and dermatitis of the eyelid (OR 2.46). Ocular surface diseases associated with ectropion included chronic conjunctivitis (OR2.89 ) and pterygium (OR 2.48). Systemic diseases such as hypertension (OR 1.46), dyslipidemia (OR 1.45), and autoimmune rheumatic diseases (OR 1.43) were also associated with involutional ectropion. This study found that localized chronic inflammatory conditions affecting the periocular tissues and ocular surface are significantly associated with the development of involutional ectropion.https://doi.org/10.1038/s41598-025-88138-6EctropionInvolutional ectropionInflammationInflammatory diseaseRisk factors |
| spellingShingle | Ahmad Mansour Tomer Kerman Nir Amitai Eran Zunz Soltan Khalaila Itai Hazan Erez Tsumi The relationship between involutional ectropion and inflammatory disorders of the eyelids and ocular surface: insights from a large-scale national study Scientific Reports Ectropion Involutional ectropion Inflammation Inflammatory disease Risk factors |
| title | The relationship between involutional ectropion and inflammatory disorders of the eyelids and ocular surface: insights from a large-scale national study |
| title_full | The relationship between involutional ectropion and inflammatory disorders of the eyelids and ocular surface: insights from a large-scale national study |
| title_fullStr | The relationship between involutional ectropion and inflammatory disorders of the eyelids and ocular surface: insights from a large-scale national study |
| title_full_unstemmed | The relationship between involutional ectropion and inflammatory disorders of the eyelids and ocular surface: insights from a large-scale national study |
| title_short | The relationship between involutional ectropion and inflammatory disorders of the eyelids and ocular surface: insights from a large-scale national study |
| title_sort | relationship between involutional ectropion and inflammatory disorders of the eyelids and ocular surface insights from a large scale national study |
| topic | Ectropion Involutional ectropion Inflammation Inflammatory disease Risk factors |
| url | https://doi.org/10.1038/s41598-025-88138-6 |
| work_keys_str_mv | AT ahmadmansour therelationshipbetweeninvolutionalectropionandinflammatorydisordersoftheeyelidsandocularsurfaceinsightsfromalargescalenationalstudy AT tomerkerman therelationshipbetweeninvolutionalectropionandinflammatorydisordersoftheeyelidsandocularsurfaceinsightsfromalargescalenationalstudy AT niramitai therelationshipbetweeninvolutionalectropionandinflammatorydisordersoftheeyelidsandocularsurfaceinsightsfromalargescalenationalstudy AT eranzunz therelationshipbetweeninvolutionalectropionandinflammatorydisordersoftheeyelidsandocularsurfaceinsightsfromalargescalenationalstudy AT soltankhalaila therelationshipbetweeninvolutionalectropionandinflammatorydisordersoftheeyelidsandocularsurfaceinsightsfromalargescalenationalstudy AT itaihazan therelationshipbetweeninvolutionalectropionandinflammatorydisordersoftheeyelidsandocularsurfaceinsightsfromalargescalenationalstudy AT ereztsumi therelationshipbetweeninvolutionalectropionandinflammatorydisordersoftheeyelidsandocularsurfaceinsightsfromalargescalenationalstudy AT ahmadmansour relationshipbetweeninvolutionalectropionandinflammatorydisordersoftheeyelidsandocularsurfaceinsightsfromalargescalenationalstudy AT tomerkerman relationshipbetweeninvolutionalectropionandinflammatorydisordersoftheeyelidsandocularsurfaceinsightsfromalargescalenationalstudy AT niramitai relationshipbetweeninvolutionalectropionandinflammatorydisordersoftheeyelidsandocularsurfaceinsightsfromalargescalenationalstudy AT eranzunz relationshipbetweeninvolutionalectropionandinflammatorydisordersoftheeyelidsandocularsurfaceinsightsfromalargescalenationalstudy AT soltankhalaila relationshipbetweeninvolutionalectropionandinflammatorydisordersoftheeyelidsandocularsurfaceinsightsfromalargescalenationalstudy AT itaihazan relationshipbetweeninvolutionalectropionandinflammatorydisordersoftheeyelidsandocularsurfaceinsightsfromalargescalenationalstudy AT ereztsumi relationshipbetweeninvolutionalectropionandinflammatorydisordersoftheeyelidsandocularsurfaceinsightsfromalargescalenationalstudy |