Toxicity evaluation of herbicides used in sugarcane crops to Zebrafish (Danio rerio)
In nature, organisms are constantly exposed to more than one toxic agent, and although the phenomenon of chemical interactions are known for some time, there are few previous studies that emphasize observation of the effects resulting from exposure to two or more substances. The aim of this study wa...
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| Language: | English |
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Centro Universitário São Camilo
2014-01-01
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| Series: | O Mundo da Saúde |
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| Online Access: | https://revistamundodasaude.emnuvens.com.br/mundodasaude/article/view/405 |
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| author | Gabrielli Aparecida Sanches Tesolin Marina Menezes Marson Claudio Martín Jonsson António José Arsénia Nogueira Daniel Andrade de Siqueira Franco Sydnei Dionísio Batista de Almeida Marcus Barifouse Matallo Monica Accaui Marcondes de Moura |
| author_facet | Gabrielli Aparecida Sanches Tesolin Marina Menezes Marson Claudio Martín Jonsson António José Arsénia Nogueira Daniel Andrade de Siqueira Franco Sydnei Dionísio Batista de Almeida Marcus Barifouse Matallo Monica Accaui Marcondes de Moura |
| author_sort | Gabrielli Aparecida Sanches Tesolin |
| collection | DOAJ |
| description | In nature, organisms are constantly exposed to more than one toxic agent, and although the phenomenon of chemical interactions
are known for some time, there are few previous studies that emphasize observation of the effects resulting from
exposure to two or more substances. The aim of this study was to evaluate the combined effect of the mixture of herbicide
Gesapax 500® (ametrina 500 g/L) and Velpar K® (diuron 468 g/kg + hexazinone 132 g/kg) on zebrafish (Danio rerio). The test
was based on the Fish Embryo Toxicity (FET) from OECD, lasting 96 hours. The concentrations tested were: 0, 21.22, 29.52,
41.08, 57.17 and 79.56 mg/L Gesapax 500 vs. 0, 15.21, 21.17, 29.46, 40.99 and 57.04 mg/L Velpar K. Tests were conducted
in triplicate and evaluated daily. LC50-96h was determined to 41.705 ± 8.373 mg/L to Gesapax 500 and 55.460 ± 20.826 mg/L
to Velpar K. The mixture model that best describes the relationship between the two components is independent action and
toxicity of the mixture is dose-dependent, occurring antagonism at low doses and synergism at high doses. The endpoints
edema, delay in general development and in yolk sac absorption and decrease in frequency of heart-beat rate were observed
from the lower concentrations of the mixture. From the data obtained, it is concluded that the mixture of Velpar K and Gesapax
500 is moderately toxic to zebrafish and that the endpoints evaluated were useful in determining its toxicity. |
| format | Article |
| id | doaj-art-d1f8de70a54444bb92fa1646bef4b343 |
| institution | Kabale University |
| issn | 0104-7809 1980-3990 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Centro Universitário São Camilo |
| record_format | Article |
| series | O Mundo da Saúde |
| spelling | doaj-art-d1f8de70a54444bb92fa1646bef4b3432025-02-11T13:32:54ZengCentro Universitário São CamiloO Mundo da Saúde0104-78091980-39902014-01-013818697341Toxicity evaluation of herbicides used in sugarcane crops to Zebrafish (Danio rerio)Gabrielli Aparecida Sanches Tesolin0Marina Menezes Marson1Claudio Martín Jonsson2António José Arsénia Nogueira3Daniel Andrade de Siqueira Franco4Sydnei Dionísio Batista de Almeida5Marcus Barifouse Matallo6Monica Accaui Marcondes de Moura7Instituto Biológico, Centro Experimental Central, Laboratório da Ciência das Plantas Daninhas, Campinas-SP, Brasil.Instituto Biológico, Centro Experimental Central, Laboratório da Ciência das Plantas Daninhas, Campinas-SP, Brasil.Embrapa Meio Ambiente, Jaguariúna-SP, Brasil.Departamento de Biologia & CESAM, Universidade de Aveiro, Campus Universitário de Santiago, Aveiro, Portugal.Instituto Biológico, Centro Experimental Central, Laboratório da Ciência das Plantas Daninhas, Campinas-SP, Brasil.Instituto Biológico, Centro Experimental Central, Laboratório da Ciência das Plantas Daninhas, Campinas-SP, Brasil.Instituto Biológico, Centro Experimental Central, Laboratório da Ciência das Plantas Daninhas, Campinas-SP, Brasil.Instituto Biológico, Centro Experimental Central, Laboratório da Ciência das Plantas Daninhas, Campinas-SP, Brasil.In nature, organisms are constantly exposed to more than one toxic agent, and although the phenomenon of chemical interactions are known for some time, there are few previous studies that emphasize observation of the effects resulting from exposure to two or more substances. The aim of this study was to evaluate the combined effect of the mixture of herbicide Gesapax 500® (ametrina 500 g/L) and Velpar K® (diuron 468 g/kg + hexazinone 132 g/kg) on zebrafish (Danio rerio). The test was based on the Fish Embryo Toxicity (FET) from OECD, lasting 96 hours. The concentrations tested were: 0, 21.22, 29.52, 41.08, 57.17 and 79.56 mg/L Gesapax 500 vs. 0, 15.21, 21.17, 29.46, 40.99 and 57.04 mg/L Velpar K. Tests were conducted in triplicate and evaluated daily. LC50-96h was determined to 41.705 ± 8.373 mg/L to Gesapax 500 and 55.460 ± 20.826 mg/L to Velpar K. The mixture model that best describes the relationship between the two components is independent action and toxicity of the mixture is dose-dependent, occurring antagonism at low doses and synergism at high doses. The endpoints edema, delay in general development and in yolk sac absorption and decrease in frequency of heart-beat rate were observed from the lower concentrations of the mixture. From the data obtained, it is concluded that the mixture of Velpar K and Gesapax 500 is moderately toxic to zebrafish and that the endpoints evaluated were useful in determining its toxicity.https://revistamundodasaude.emnuvens.com.br/mundodasaude/article/view/405herbicides - toxicity. diuron. acute toxicity. complex mixtures. |
| spellingShingle | Gabrielli Aparecida Sanches Tesolin Marina Menezes Marson Claudio Martín Jonsson António José Arsénia Nogueira Daniel Andrade de Siqueira Franco Sydnei Dionísio Batista de Almeida Marcus Barifouse Matallo Monica Accaui Marcondes de Moura Toxicity evaluation of herbicides used in sugarcane crops to Zebrafish (Danio rerio) O Mundo da Saúde herbicides - toxicity. diuron. acute toxicity. complex mixtures. |
| title | Toxicity evaluation of herbicides used in sugarcane crops to Zebrafish (Danio rerio) |
| title_full | Toxicity evaluation of herbicides used in sugarcane crops to Zebrafish (Danio rerio) |
| title_fullStr | Toxicity evaluation of herbicides used in sugarcane crops to Zebrafish (Danio rerio) |
| title_full_unstemmed | Toxicity evaluation of herbicides used in sugarcane crops to Zebrafish (Danio rerio) |
| title_short | Toxicity evaluation of herbicides used in sugarcane crops to Zebrafish (Danio rerio) |
| title_sort | toxicity evaluation of herbicides used in sugarcane crops to zebrafish danio rerio |
| topic | herbicides - toxicity. diuron. acute toxicity. complex mixtures. |
| url | https://revistamundodasaude.emnuvens.com.br/mundodasaude/article/view/405 |
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