A comprehensive review of AI-based collagen valorization: Recent trends, innovations in extraction, and applications

Collagen, constituting approximately 30 % of total body proteins, is a critical structural protein with extensive applications in biomedical, cosmetic, and food industries. Despite its importance, large volumes of collagen-rich organic waste generated by meat, leather, and seafood industries remain...

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Main Authors: Arthi Srinivasan, Arun Gupta, Vigneswaran Narayanamurthy
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Green Analytical Chemistry
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Online Access:http://www.sciencedirect.com/science/article/pii/S2772577425000096
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author Arthi Srinivasan
Arun Gupta
Vigneswaran Narayanamurthy
author_facet Arthi Srinivasan
Arun Gupta
Vigneswaran Narayanamurthy
author_sort Arthi Srinivasan
collection DOAJ
description Collagen, constituting approximately 30 % of total body proteins, is a critical structural protein with extensive applications in biomedical, cosmetic, and food industries. Despite its importance, large volumes of collagen-rich organic waste generated by meat, leather, and seafood industries remain underutilized, leading to significant environmental challenges. Piscine waste contributes up to 70 % of total fish body weight, while poultry farms produce approximately 89,000 tons of solid waste annually. This review provides a detailed analysis of collagen-rich waste sources, including bovine, porcine, piscine, caprine, ovine, and avian, examining their waste percentages, protein content, and extraction efficiencies. The study explores the transformative role of artificial intelligence (AI) in optimizing collagen extraction processes, enhancing efficiency, yield, and quality while reducing energy consumption and waste generation. AI-driven methods have demonstrated improvements in energy efficiency by up to 40 % and reductions in waste by 45 %, enabling environmentally sustainable and cost-effective practices. Collagen valorization is further aligned with circular economy principles, focusing on converting waste into high-value products such as collagen peptides, biomaterials, and functional foods. By integrating advanced AI technologies with diverse collagen sources, this review provides a comprehensive framework for sustainable collagen processing that addresses environmental challenges and enhances resource utilization. The study emphasizes the potential to create economically valuable products while promoting environmental sustainability and innovation, paving the way for efficient and eco-friendly practices in the collagen industry through a holistic and multidisciplinary approach.
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spelling doaj-art-d2697f71e2a549b4a6f8201c5f41a7ab2025-02-11T04:35:41ZengElsevierGreen Analytical Chemistry2772-57742025-03-0112100212A comprehensive review of AI-based collagen valorization: Recent trends, innovations in extraction, and applicationsArthi Srinivasan0Arun Gupta1Vigneswaran Narayanamurthy2Department of Engineering Technology, Faculty of Information & Communication Technology, Universiti Teknikal Malaysia Melaka, Hang Tuah Jaya, Durian Tunggal, Melaka 76100, Malaysia; Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang (UMP), Lebuhraya Tun Razak, Gambang, Kuantan, Pahang 26300, Malaysia; Corresponding author at: Department of Engineering Technology, Faculty of Information & Communication Technology, Universiti Teknikal Malaysia Melaka, Hang Tuah Jaya, Durian Tunggal, Melaka 76100, Malaysia.La Proteina Pvt. Ltd Kuantan, MalaysiaCentre of Excellence in MEMS & Microfluidics, Rajalakshmi Engineering College, Chennai 602105, India; Department of Biomedical Engineering, Rajalakshmi Engineering College, Chennai 602105, IndiaCollagen, constituting approximately 30 % of total body proteins, is a critical structural protein with extensive applications in biomedical, cosmetic, and food industries. Despite its importance, large volumes of collagen-rich organic waste generated by meat, leather, and seafood industries remain underutilized, leading to significant environmental challenges. Piscine waste contributes up to 70 % of total fish body weight, while poultry farms produce approximately 89,000 tons of solid waste annually. This review provides a detailed analysis of collagen-rich waste sources, including bovine, porcine, piscine, caprine, ovine, and avian, examining their waste percentages, protein content, and extraction efficiencies. The study explores the transformative role of artificial intelligence (AI) in optimizing collagen extraction processes, enhancing efficiency, yield, and quality while reducing energy consumption and waste generation. AI-driven methods have demonstrated improvements in energy efficiency by up to 40 % and reductions in waste by 45 %, enabling environmentally sustainable and cost-effective practices. Collagen valorization is further aligned with circular economy principles, focusing on converting waste into high-value products such as collagen peptides, biomaterials, and functional foods. By integrating advanced AI technologies with diverse collagen sources, this review provides a comprehensive framework for sustainable collagen processing that addresses environmental challenges and enhances resource utilization. The study emphasizes the potential to create economically valuable products while promoting environmental sustainability and innovation, paving the way for efficient and eco-friendly practices in the collagen industry through a holistic and multidisciplinary approach.http://www.sciencedirect.com/science/article/pii/S2772577425000096CollagenCollagenous sourcesCollagen extractionValorizationIndustrial waste
spellingShingle Arthi Srinivasan
Arun Gupta
Vigneswaran Narayanamurthy
A comprehensive review of AI-based collagen valorization: Recent trends, innovations in extraction, and applications
Green Analytical Chemistry
Collagen
Collagenous sources
Collagen extraction
Valorization
Industrial waste
title A comprehensive review of AI-based collagen valorization: Recent trends, innovations in extraction, and applications
title_full A comprehensive review of AI-based collagen valorization: Recent trends, innovations in extraction, and applications
title_fullStr A comprehensive review of AI-based collagen valorization: Recent trends, innovations in extraction, and applications
title_full_unstemmed A comprehensive review of AI-based collagen valorization: Recent trends, innovations in extraction, and applications
title_short A comprehensive review of AI-based collagen valorization: Recent trends, innovations in extraction, and applications
title_sort comprehensive review of ai based collagen valorization recent trends innovations in extraction and applications
topic Collagen
Collagenous sources
Collagen extraction
Valorization
Industrial waste
url http://www.sciencedirect.com/science/article/pii/S2772577425000096
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