Trends in breast cancer among elderly women: Development in estrogen and HER2 subtypes in the last ten years
Background: Increasing life expectancy increases breast cancer (BC) rates in elderly, where better health allows for improved tolerance of treatments. We assessed trends in BC incidence of tumor subtypes for women with focus on the elderly. Methods: Changes in BC incidence in women by age from 2012...
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Elsevier
2025-02-01
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| Series: | Breast |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977624001917 |
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| author | Frederik K. Palshof Lina S. Mørch Maj-Britt R. Jensen Hans H. Storm Niels Kroman Tove H.F. Tvedskov |
| author_facet | Frederik K. Palshof Lina S. Mørch Maj-Britt R. Jensen Hans H. Storm Niels Kroman Tove H.F. Tvedskov |
| author_sort | Frederik K. Palshof |
| collection | DOAJ |
| description | Background: Increasing life expectancy increases breast cancer (BC) rates in elderly, where better health allows for improved tolerance of treatments. We assessed trends in BC incidence of tumor subtypes for women with focus on the elderly. Methods: Changes in BC incidence in women by age from 2012 to 2021 were assessed using data from the Nordic countries. We calculated the incidence of BC subtypes by age group using data from the Danish Breast Cancer Group (DBCG) database. We used generalized linear models assuming a Poisson distribution. Results: In the Nordic countries, 205 305 women were diagnosed with BC between 2012 and 2021. In Denmark, 50 858 BC patients were diagnosed between 2012 and 2022, identified with tumor characteristics. Incidence of BC among women aged 80+ increased significantly across the Nordic Countries, with 1.24 % per year (95 % CI: 0.07 %: 2.41 %). In Denmark, in the 80+ group, the ER+/HER2- subtype had the highest increase, with 1.98 % per year (95 % CI: 1.10 %: 2.87 %). Conclusion: Across the Nordic countries, incidence of BC in women aged 80+ increased. In Denmark, rising incidence of BC is driven by the ER+/HER2- subtype in the 80+ group, which has the best prognosis and gentle treatments. More elderly BC patients will require treatment and follow-up in the future. |
| format | Article |
| id | doaj-art-d276de83069e4c17bb7cdfcd01a71462 |
| institution | Kabale University |
| issn | 1532-3080 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj-art-d276de83069e4c17bb7cdfcd01a714622025-02-12T05:30:36ZengElsevierBreast1532-30802025-02-0179103860Trends in breast cancer among elderly women: Development in estrogen and HER2 subtypes in the last ten yearsFrederik K. Palshof0Lina S. Mørch1Maj-Britt R. Jensen2Hans H. Storm3Niels Kroman4Tove H.F. Tvedskov5The Danish Cancer Society, Danish Cancer Institute, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark; Department of Breast Surgery, Gentofte Hospital, Gentofte Hospitalsvej 1, 2900 Hellerup, Denmark; Corresponding author. The Danish Cancer Society, Danish Cancer Institute, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark.The Danish Cancer Society, Danish Cancer Institute, Strandboulevarden 49, 2100 Copenhagen Ø, DenmarkDanish Breast Cancer Group (DBCG), Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Strandboulevarden 49, 2100 Copenhagen Ø, DenmarkThe Danish Cancer Society, Danish Cancer Institute, Strandboulevarden 49, 2100 Copenhagen Ø, DenmarkThe Danish Cancer Society, Danish Cancer Institute, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark; Department of Breast Surgery, Gentofte Hospital, Gentofte Hospitalsvej 1, 2900 Hellerup, DenmarkDepartment of Breast Surgery, Gentofte Hospital, Gentofte Hospitalsvej 1, 2900 Hellerup, DenmarkBackground: Increasing life expectancy increases breast cancer (BC) rates in elderly, where better health allows for improved tolerance of treatments. We assessed trends in BC incidence of tumor subtypes for women with focus on the elderly. Methods: Changes in BC incidence in women by age from 2012 to 2021 were assessed using data from the Nordic countries. We calculated the incidence of BC subtypes by age group using data from the Danish Breast Cancer Group (DBCG) database. We used generalized linear models assuming a Poisson distribution. Results: In the Nordic countries, 205 305 women were diagnosed with BC between 2012 and 2021. In Denmark, 50 858 BC patients were diagnosed between 2012 and 2022, identified with tumor characteristics. Incidence of BC among women aged 80+ increased significantly across the Nordic Countries, with 1.24 % per year (95 % CI: 0.07 %: 2.41 %). In Denmark, in the 80+ group, the ER+/HER2- subtype had the highest increase, with 1.98 % per year (95 % CI: 1.10 %: 2.87 %). Conclusion: Across the Nordic countries, incidence of BC in women aged 80+ increased. In Denmark, rising incidence of BC is driven by the ER+/HER2- subtype in the 80+ group, which has the best prognosis and gentle treatments. More elderly BC patients will require treatment and follow-up in the future.http://www.sciencedirect.com/science/article/pii/S0960977624001917Breast cancer subtypesEstrogen receptorHER2Incidence ratesAge groups |
| spellingShingle | Frederik K. Palshof Lina S. Mørch Maj-Britt R. Jensen Hans H. Storm Niels Kroman Tove H.F. Tvedskov Trends in breast cancer among elderly women: Development in estrogen and HER2 subtypes in the last ten years Breast Breast cancer subtypes Estrogen receptor HER2 Incidence rates Age groups |
| title | Trends in breast cancer among elderly women: Development in estrogen and HER2 subtypes in the last ten years |
| title_full | Trends in breast cancer among elderly women: Development in estrogen and HER2 subtypes in the last ten years |
| title_fullStr | Trends in breast cancer among elderly women: Development in estrogen and HER2 subtypes in the last ten years |
| title_full_unstemmed | Trends in breast cancer among elderly women: Development in estrogen and HER2 subtypes in the last ten years |
| title_short | Trends in breast cancer among elderly women: Development in estrogen and HER2 subtypes in the last ten years |
| title_sort | trends in breast cancer among elderly women development in estrogen and her2 subtypes in the last ten years |
| topic | Breast cancer subtypes Estrogen receptor HER2 Incidence rates Age groups |
| url | http://www.sciencedirect.com/science/article/pii/S0960977624001917 |
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