The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study
Purpose: Plantago Major (PM) is widely used for the treatment of different diseases due to several active compounds. Previous studies demonstrated the treatment effect of this plant on lung cancer cell lines. Here, we introduced a patient having lung cancer proved by Computed Tomography (CT) and pa...
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Tehran University of Medical Sciences
2025-01-01
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| Series: | Frontiers in Biomedical Technologies |
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| Online Access: | https://fbt.tums.ac.ir/index.php/fbt/article/view/894 |
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| author | Saade Abdalkareem Jasim Bashar Mudhaffar Abdullah Patricio Yánez-Moretta Wesam R. Kadhum Yasser Fakri Mustafa Enas R. Alwaily Munther Abosoda Ali Alsalamy Sada Ghalib Al-Musawi Alaa A. Omran |
| author_facet | Saade Abdalkareem Jasim Bashar Mudhaffar Abdullah Patricio Yánez-Moretta Wesam R. Kadhum Yasser Fakri Mustafa Enas R. Alwaily Munther Abosoda Ali Alsalamy Sada Ghalib Al-Musawi Alaa A. Omran |
| author_sort | Saade Abdalkareem Jasim |
| collection | DOAJ |
| description |
Purpose: Plantago Major (PM) is widely used for the treatment of different diseases due to several active compounds. Previous studies demonstrated the treatment effect of this plant on lung cancer cell lines. Here, we introduced a patient having lung cancer proved by Computed Tomography (CT) and pathological findings. The treatment effect of PM was assessed and presented based on CT and laboratory examinations for this patient as a first human case study.
Materials and Methods: A 64-year-old woman, with gastrointestinal bleeding as well as high Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP) levels, was examined by the chest CT scan for suspicious lung cancer. Pathological findings confirmed the non-small cell lung cancer (adenocarcinoma, stage IIA). The patient consumed 150 ml of PM seeds extract (3-4 times daily) orally for about 4 months. Follow-up CT and laboratory examinations were performed after the treatment period to assess the effect of PM.
Results: The volume of the tumor was reduced by about 62% (based on CT imaging findings) after the treatment with PM. In addition, the laboratory examinations illustrate that ESR and CRP levels reduced remarkably (from 97 mm/h to 24 mm/h for ESR; from 36.8 mg/L to 1.2 mg/L for CRP) after the treatment.
Conclusion: Based on our human study, PM, as a natural compound with antioxidant, anti-inflammatory, and antibiotic characteristics, could have an anti-proliferative effect on non-small cell lung cancer. However, more follow-up examinations on big sample sizes are needed to assess the treatment effect of PM.
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| format | Article |
| id | doaj-art-d290f96a901c4ed9ae7791a23f012b08 |
| institution | Kabale University |
| issn | 2345-5837 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Frontiers in Biomedical Technologies |
| spelling | doaj-art-d290f96a901c4ed9ae7791a23f012b082025-02-09T08:55:53ZengTehran University of Medical SciencesFrontiers in Biomedical Technologies2345-58372025-01-0112110.18502/fbt.v12i1.17744The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report StudySaade Abdalkareem Jasim0Bashar Mudhaffar Abdullah1Patricio Yánez-Moretta2Wesam R. Kadhum3Yasser Fakri Mustafa4Enas R. Alwaily5Munther Abosoda6Ali Alsalamy7Sada Ghalib Al-Musawi8Alaa A. Omran9edical Laboratory Techniques Department, Al-maarif University College, Anbar, IraqClinical Laboratory Technology Department, Al-Rafidain University College, Baghdad, IraqProfessor Escuela de Ciencias Biológicas e Ingeniería, Universidad de Investigación de Tecnología Experimental Yachay, Urcuquí, EcuadorDepartment of Pharmacy, Kut University College, Kut 52001, Wasit, IraqDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul-41001, IraqMicrobiology Research Group, College of Pharmacy, Al-Ayen University, Thi-Qar, IraqCollege of Pharmacy, The Islamic University of Babylon, IraqCollege of Technical Engineering, Imam Ja’afar Al‐Sadiq University, Al‐Muthanna 66002, IraqCollege of Pharmacy, National University of Science and Technology, Dhi Qar, IraqDepartment of Engineering, AL-Nisour University College, Baghdad, Iraq Purpose: Plantago Major (PM) is widely used for the treatment of different diseases due to several active compounds. Previous studies demonstrated the treatment effect of this plant on lung cancer cell lines. Here, we introduced a patient having lung cancer proved by Computed Tomography (CT) and pathological findings. The treatment effect of PM was assessed and presented based on CT and laboratory examinations for this patient as a first human case study. Materials and Methods: A 64-year-old woman, with gastrointestinal bleeding as well as high Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP) levels, was examined by the chest CT scan for suspicious lung cancer. Pathological findings confirmed the non-small cell lung cancer (adenocarcinoma, stage IIA). The patient consumed 150 ml of PM seeds extract (3-4 times daily) orally for about 4 months. Follow-up CT and laboratory examinations were performed after the treatment period to assess the effect of PM. Results: The volume of the tumor was reduced by about 62% (based on CT imaging findings) after the treatment with PM. In addition, the laboratory examinations illustrate that ESR and CRP levels reduced remarkably (from 97 mm/h to 24 mm/h for ESR; from 36.8 mg/L to 1.2 mg/L for CRP) after the treatment. Conclusion: Based on our human study, PM, as a natural compound with antioxidant, anti-inflammatory, and antibiotic characteristics, could have an anti-proliferative effect on non-small cell lung cancer. However, more follow-up examinations on big sample sizes are needed to assess the treatment effect of PM. https://fbt.tums.ac.ir/index.php/fbt/article/view/894Non-Small Cell Lung CancerPlantago MajorComputed Tomography |
| spellingShingle | Saade Abdalkareem Jasim Bashar Mudhaffar Abdullah Patricio Yánez-Moretta Wesam R. Kadhum Yasser Fakri Mustafa Enas R. Alwaily Munther Abosoda Ali Alsalamy Sada Ghalib Al-Musawi Alaa A. Omran The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study Frontiers in Biomedical Technologies Non-Small Cell Lung Cancer Plantago Major Computed Tomography |
| title | The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study |
| title_full | The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study |
| title_fullStr | The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study |
| title_full_unstemmed | The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study |
| title_short | The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study |
| title_sort | treatment effect of plantago major on lung cancer based on the computed tomography and pathological findings a case report study |
| topic | Non-Small Cell Lung Cancer Plantago Major Computed Tomography |
| url | https://fbt.tums.ac.ir/index.php/fbt/article/view/894 |
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