A Cross Sectional Study on Thrombocytopenia with Mean Platelet Volume and Platelet Distribution Width in Patient with Febrile Illness
Introduction: Thrombocytopenia is characterized by reduced platelet count, affecting men and women equally. It is usually associated with conditions such as febrile illnesses like dengue fever, malaria, and other infectious etiology. The causes of thrombocytopenia can be evaluated by studying the pl...
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National Board of Examinations
2025-02-01
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| Series: | National Board of Examinations Journal of Medical Sciences |
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| author | Vidhya.G J.Margaret Theresa J.S. Sukanya Santha Sandasivan Gerard Rakesh. J |
| author_facet | Vidhya.G J.Margaret Theresa J.S. Sukanya Santha Sandasivan Gerard Rakesh. J |
| author_sort | Vidhya.G |
| collection | DOAJ |
| description | Introduction: Thrombocytopenia is characterized by reduced platelet count, affecting men and women equally. It is usually associated with conditions such as febrile illnesses like dengue fever, malaria, and other infectious etiology. The causes of thrombocytopenia can be evaluated by studying the platelet parameters. Aim: Investigating the clinical and pathological characteristics of Acute Febrile Illness and Assessing Thrombocytopenia Using Mean Platelet Volume and Platelet Distribution Width. Materials and Methods: Study was conducted on 85 individuals, both male and female, aged between 18 and 65 years, who presented with thrombocytopenia and acute febrile infections. The cases of thrombocytopenia were classified as mild, moderate, or severe, and peripheral smears were performed on all 85 cases to rule out pseudothrombocytopenia. Several subgroups were also derived after evaluating the etiology of thrombocytopenia. Results: In all 85 individuals who presented with thrombocytopenia, MPV
and PDW values were calculated. There was an increase in MPV and PDW values on day 1 compared to the values on day 2 and day 3. Thrombocytopenia severity was categorized as mild, moderate, or severe based on the MPV and PDW values. Conclusion: Platelet volume parameters such as mean platelet volume (MPV) and platelet distribution width (PDW) offer valuable insights into the mechanisms of thrombocytopenia. PDW, in particular, plays a critical role among these parameters. When assessed alongside other parameters, PDW can provide important information about the mechanisms behind platelet destruction. |
| format | Article |
| id | doaj-art-d2f38e4800a142038c093f91dc069b5c |
| institution | Kabale University |
| issn | 2583-7524 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | National Board of Examinations |
| record_format | Article |
| series | National Board of Examinations Journal of Medical Sciences |
| spelling | doaj-art-d2f38e4800a142038c093f91dc069b5c2025-02-11T06:55:18ZengNational Board of ExaminationsNational Board of Examinations Journal of Medical Sciences2583-75242025-02-01Volume 3217918710.61770/NBEJMS.2025.v03.i02.005A Cross Sectional Study on Thrombocytopenia with Mean Platelet Volume and Platelet Distribution Width in Patient with Febrile IllnessVidhya.G0J.Margaret Theresa1J.S. Sukanya2Santha Sandasivan3Gerard Rakesh. J4Assistant Professor, Department of Pathology, Sri Venkateshwaraa Medical College Hospital and Research Centre, Pondicherry, IndiaAssociate Professor, Department of Pathology, Aarupadai Veedu Medical College and Hospital Vinayaka Mission’s Research Foundation (Deemed to be university), Kirumampakkam, Puducherry, IndiaAssociate Professor, Department of Pathology, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research (Affiliated to the Tamil Nadu Dr. M.G.R Medical University, Chennai), Melmaruvathur, Tamil Nadu, IndiaProfessor and HOD, Department of Pathology, Sree Mookambika Institute of Medical Sciences, Kulasekharam, Tamil NaduProfessor, Department of Microbiology, Sri Venkateshwaraa Medical College Hospital and Research Centre, Pondicherry, IndiaIntroduction: Thrombocytopenia is characterized by reduced platelet count, affecting men and women equally. It is usually associated with conditions such as febrile illnesses like dengue fever, malaria, and other infectious etiology. The causes of thrombocytopenia can be evaluated by studying the platelet parameters. Aim: Investigating the clinical and pathological characteristics of Acute Febrile Illness and Assessing Thrombocytopenia Using Mean Platelet Volume and Platelet Distribution Width. Materials and Methods: Study was conducted on 85 individuals, both male and female, aged between 18 and 65 years, who presented with thrombocytopenia and acute febrile infections. The cases of thrombocytopenia were classified as mild, moderate, or severe, and peripheral smears were performed on all 85 cases to rule out pseudothrombocytopenia. Several subgroups were also derived after evaluating the etiology of thrombocytopenia. Results: In all 85 individuals who presented with thrombocytopenia, MPV and PDW values were calculated. There was an increase in MPV and PDW values on day 1 compared to the values on day 2 and day 3. Thrombocytopenia severity was categorized as mild, moderate, or severe based on the MPV and PDW values. Conclusion: Platelet volume parameters such as mean platelet volume (MPV) and platelet distribution width (PDW) offer valuable insights into the mechanisms of thrombocytopenia. PDW, in particular, plays a critical role among these parameters. When assessed alongside other parameters, PDW can provide important information about the mechanisms behind platelet destruction. https://natboard.edu.in/ejournal/articledtl?x=RSsyTmxzbFVoL0wvaTBxc3h4czd1UT09thrombocytopeniaacute febrile illnessesmean platelet volumeplatelet distribution width |
| spellingShingle | Vidhya.G J.Margaret Theresa J.S. Sukanya Santha Sandasivan Gerard Rakesh. J A Cross Sectional Study on Thrombocytopenia with Mean Platelet Volume and Platelet Distribution Width in Patient with Febrile Illness National Board of Examinations Journal of Medical Sciences thrombocytopenia acute febrile illnesses mean platelet volume platelet distribution width |
| title | A Cross Sectional Study on Thrombocytopenia with Mean Platelet Volume and Platelet Distribution Width in Patient with Febrile Illness |
| title_full | A Cross Sectional Study on Thrombocytopenia with Mean Platelet Volume and Platelet Distribution Width in Patient with Febrile Illness |
| title_fullStr | A Cross Sectional Study on Thrombocytopenia with Mean Platelet Volume and Platelet Distribution Width in Patient with Febrile Illness |
| title_full_unstemmed | A Cross Sectional Study on Thrombocytopenia with Mean Platelet Volume and Platelet Distribution Width in Patient with Febrile Illness |
| title_short | A Cross Sectional Study on Thrombocytopenia with Mean Platelet Volume and Platelet Distribution Width in Patient with Febrile Illness |
| title_sort | cross sectional study on thrombocytopenia with mean platelet volume and platelet distribution width in patient with febrile illness |
| topic | thrombocytopenia acute febrile illnesses mean platelet volume platelet distribution width |
| url | https://natboard.edu.in/ejournal/articledtl?x=RSsyTmxzbFVoL0wvaTBxc3h4czd1UT09 |
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