Inflammation mediates the adverse effects of urinary phthalate exposure on metabolic disease risk: Results from NHANES 2005–2016
Background: Phthalates are a category of chemicals commonly utilized in various industrial applications and everyday products. Their associations with health issues remains a significant concern. Although some studies have suggested associations between phthalates and metabolic diseases, the current...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324016531 |
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| author | Chenyang Gu Teng Yao Chenxian Dong Zuhai Chen Wanting Wei Xiaoju Li Qiang Niu Yizhong Yan Yunhua Hu |
| author_facet | Chenyang Gu Teng Yao Chenxian Dong Zuhai Chen Wanting Wei Xiaoju Li Qiang Niu Yizhong Yan Yunhua Hu |
| author_sort | Chenyang Gu |
| collection | DOAJ |
| description | Background: Phthalates are a category of chemicals commonly utilized in various industrial applications and everyday products. Their associations with health issues remains a significant concern. Although some studies have suggested associations between phthalates and metabolic diseases, the current understanding of the associations is still limited, especially the lack of effects of mixed exposure. Methods: This cross-sectional study included information from 9217 participants in National Health and Nutrition Examination Survey (NHANES) from 2005 to 2016. Multivariate logistic regression was used to explore the associations between single phthalate exposure and obesity and its complications. Weighted quantile sum (WQS) regression and Quantile G-Computation (Qgcomp) models were used to further analyze the associations between mixed phthalate exposure and obesity and its complications. Mediated analysis was used to explore the mediating role of immune cells in the relationship between phthalate exposure and obesity and its complications. Results: MiBP, MCOP and MBzP were associated with an increased risk of obesity. MiBP and MCOP were associated with an increased risk of abdominal obesity. MCNP, MCOP, MEHHP, MEOHP and MECPP were positively associated with T2DM. Mixed phthalate exposure was positively associated with obesity and T2DM. Monocytes mediated the effects of MiBP, MEHP and MBzP on obesity, explaining 7.94 %, −2.32 % and 6.69% of the total effect, respectively. Conclusions: This study revealed a significant association between mixed phthalate exposure and obesity and its complications, underlining the importance of considering the interactions of these compounds. The synergistic effects of multiple phthalates may exacerbate health risks. |
| format | Article |
| id | doaj-art-d306cc7bc1b0485fbc5d2bcfb46db809 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-d306cc7bc1b0485fbc5d2bcfb46db8092025-02-12T05:29:52ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117577Inflammation mediates the adverse effects of urinary phthalate exposure on metabolic disease risk: Results from NHANES 2005–2016Chenyang Gu0Teng Yao1Chenxian Dong2Zuhai Chen3Wanting Wei4Xiaoju Li5Qiang Niu6Yizhong Yan7Yunhua Hu8Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, ChinaDepartment of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, China; Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, the Xinjiang Production and Construction Corps, China; Key Laboratory of Preventive Medicine, Shihezi University, Shihezi, Xinjiang, ChinaDepartment of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, China; Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, the Xinjiang Production and Construction Corps, China; Key Laboratory of Preventive Medicine, Shihezi University, Shihezi, Xinjiang, ChinaDepartment of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, ChinaDepartment of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, ChinaDepartment of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, China; Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, the Xinjiang Production and Construction Corps, China; Key Laboratory of Preventive Medicine, Shihezi University, Shihezi, Xinjiang, China; Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, ChinaDepartment of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, China; Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, the Xinjiang Production and Construction Corps, China; Key Laboratory of Preventive Medicine, Shihezi University, Shihezi, Xinjiang, China; Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, China; Correspondence to: Department of Preventive Medicine, School of Medicine, Shihezi University, North 2th Road, Shihezi, Xinjiang 832000, China.Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, China; Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, the Xinjiang Production and Construction Corps, China; Key Laboratory of Preventive Medicine, Shihezi University, Shihezi, Xinjiang, China; Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, China; Correspondence to: Department of Preventive Medicine, School of Medicine, Shihezi University, North 2th Road, Shihezi, Xinjiang 832000, China.Department of Preventive Medicine, School of Medicine, Shihezi University, Shihezi, Xinjiang, China; Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security, the Xinjiang Production and Construction Corps, China; Key Laboratory of Preventive Medicine, Shihezi University, Shihezi, Xinjiang, China; Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education), School of Medicine, Shihezi University, Shihezi, Xinjiang, China; Correspondence to: Department of Preventive Medicine, School of Medicine, Shihezi University, North 2th Road, Shihezi, Xinjiang 832000, China.Background: Phthalates are a category of chemicals commonly utilized in various industrial applications and everyday products. Their associations with health issues remains a significant concern. Although some studies have suggested associations between phthalates and metabolic diseases, the current understanding of the associations is still limited, especially the lack of effects of mixed exposure. Methods: This cross-sectional study included information from 9217 participants in National Health and Nutrition Examination Survey (NHANES) from 2005 to 2016. Multivariate logistic regression was used to explore the associations between single phthalate exposure and obesity and its complications. Weighted quantile sum (WQS) regression and Quantile G-Computation (Qgcomp) models were used to further analyze the associations between mixed phthalate exposure and obesity and its complications. Mediated analysis was used to explore the mediating role of immune cells in the relationship between phthalate exposure and obesity and its complications. Results: MiBP, MCOP and MBzP were associated with an increased risk of obesity. MiBP and MCOP were associated with an increased risk of abdominal obesity. MCNP, MCOP, MEHHP, MEOHP and MECPP were positively associated with T2DM. Mixed phthalate exposure was positively associated with obesity and T2DM. Monocytes mediated the effects of MiBP, MEHP and MBzP on obesity, explaining 7.94 %, −2.32 % and 6.69% of the total effect, respectively. Conclusions: This study revealed a significant association between mixed phthalate exposure and obesity and its complications, underlining the importance of considering the interactions of these compounds. The synergistic effects of multiple phthalates may exacerbate health risks.http://www.sciencedirect.com/science/article/pii/S0147651324016531PhthalateMixed exposureMetabolic diseasesObesityMediating effects |
| spellingShingle | Chenyang Gu Teng Yao Chenxian Dong Zuhai Chen Wanting Wei Xiaoju Li Qiang Niu Yizhong Yan Yunhua Hu Inflammation mediates the adverse effects of urinary phthalate exposure on metabolic disease risk: Results from NHANES 2005–2016 Ecotoxicology and Environmental Safety Phthalate Mixed exposure Metabolic diseases Obesity Mediating effects |
| title | Inflammation mediates the adverse effects of urinary phthalate exposure on metabolic disease risk: Results from NHANES 2005–2016 |
| title_full | Inflammation mediates the adverse effects of urinary phthalate exposure on metabolic disease risk: Results from NHANES 2005–2016 |
| title_fullStr | Inflammation mediates the adverse effects of urinary phthalate exposure on metabolic disease risk: Results from NHANES 2005–2016 |
| title_full_unstemmed | Inflammation mediates the adverse effects of urinary phthalate exposure on metabolic disease risk: Results from NHANES 2005–2016 |
| title_short | Inflammation mediates the adverse effects of urinary phthalate exposure on metabolic disease risk: Results from NHANES 2005–2016 |
| title_sort | inflammation mediates the adverse effects of urinary phthalate exposure on metabolic disease risk results from nhanes 2005 2016 |
| topic | Phthalate Mixed exposure Metabolic diseases Obesity Mediating effects |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324016531 |
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