Association between joint exposure to ambient air pollutants and carotid plaque: The mediating role of cardiometabolic risk factors
Background: Research has shown that exposure to joint air pollution is related to atherosclerosis, but little evidence has been found for carotid plaques. Our objective is to assess the association between exposure to joint air pollutants and carotid plaque and explore the mediating role of cardiome...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325000910 |
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| author | Yunfei Li Ze Han Xiaoyu Zhao Yueruijing Liu Zhiyuan Wu Jinqi Wang Xia Li Xiuhua Guo Lixin Tao |
| author_facet | Yunfei Li Ze Han Xiaoyu Zhao Yueruijing Liu Zhiyuan Wu Jinqi Wang Xia Li Xiuhua Guo Lixin Tao |
| author_sort | Yunfei Li |
| collection | DOAJ |
| description | Background: Research has shown that exposure to joint air pollution is related to atherosclerosis, but little evidence has been found for carotid plaques. Our objective is to assess the association between exposure to joint air pollutants and carotid plaque and explore the mediating role of cardiometabolic factors in this relationship. Methods: The Beijing Health Management Cohort (BMHC) study followed participants recruited from 2013 to 2014 until December 31, 2020. All participants underwent carotid ultrasound and were free of carotid plaque at baseline. A satellite-based land-use regression (LUR) model was applied to estimate air pollution exposure. The joint exposure to air pollutants was assessed by incorporating a weighted air pollution score. A modified Poisson regression model was conducted to investigate the relationship between exposure to air pollution and carotid plaque occurrence. Mediation analysis explored how cardiometabolic factors mediate the relationships between exposure to joint air pollution and carotid plaque risk. Results: During an average follow-up period 4 years, 1240 cases of carotid plaque were identified among 7358 participants. Each interquartile range (IQR) increase in air pollutants was associated with the following relative risk (RR) and 95 % confidence intervals (95 % CIs) for carotid plaque: 2.5-micrometer particulate matter (PM2.5), 1,04 (1.01, 1.07), 10-micrometer particulate matter (PM10), 1.10 (1.01, 1.20), sulfur dioxide (SO2), 1.28 (1.15, 1.42), ozone (O3), 1.18 (1.01, 1.37), and carbon monoxide (CO), 1.32 (1.15, 1.50). Joint exposure to air pollution was positively and linearly associated with the occurrence of carotid plaque, with low-density cholesterol (LDL-C) and mean arterial pressure (MAP) mediating 2.24 % and 4.28 % of the association, respectively. Conclusions: Long-term joint exposure to ambient air pollutants elevates the risk of developing carotid plaque. LDL-C and MAP suggest partial mediating effects of joint air pollution on carotid plaques. Our results emphasize the need to thoroughly evaluate various air pollutants concerning carotid plaque. |
| format | Article |
| id | doaj-art-d344f257b5d54af48f27ea5f4ba3b46d |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-d344f257b5d54af48f27ea5f4ba3b46d2025-02-12T05:30:12ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117755Association between joint exposure to ambient air pollutants and carotid plaque: The mediating role of cardiometabolic risk factorsYunfei Li0Ze Han1Xiaoyu Zhao2Yueruijing Liu3Zhiyuan Wu4Jinqi Wang5Xia Li6Xiuhua Guo7Lixin Tao8Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaBeijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaBeijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaBeijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaHarvard T.H. Chan School of Public Health, 655 Huntington Ave, Boston, MA 02115, USABeijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Mathematics and Statistics, La Trobe University, Melbourne 3086, AustraliaBeijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China; Centre for Precision Health, School of Medical and Health Sciences, Edith Cowan University, Joondalup, AustraliaBeijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China; Harvard T.H. Chan School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA; Correspondence to: Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No.10 Xitoutiao, Youanmen Street, Beijing 100069, China.Background: Research has shown that exposure to joint air pollution is related to atherosclerosis, but little evidence has been found for carotid plaques. Our objective is to assess the association between exposure to joint air pollutants and carotid plaque and explore the mediating role of cardiometabolic factors in this relationship. Methods: The Beijing Health Management Cohort (BMHC) study followed participants recruited from 2013 to 2014 until December 31, 2020. All participants underwent carotid ultrasound and were free of carotid plaque at baseline. A satellite-based land-use regression (LUR) model was applied to estimate air pollution exposure. The joint exposure to air pollutants was assessed by incorporating a weighted air pollution score. A modified Poisson regression model was conducted to investigate the relationship between exposure to air pollution and carotid plaque occurrence. Mediation analysis explored how cardiometabolic factors mediate the relationships between exposure to joint air pollution and carotid plaque risk. Results: During an average follow-up period 4 years, 1240 cases of carotid plaque were identified among 7358 participants. Each interquartile range (IQR) increase in air pollutants was associated with the following relative risk (RR) and 95 % confidence intervals (95 % CIs) for carotid plaque: 2.5-micrometer particulate matter (PM2.5), 1,04 (1.01, 1.07), 10-micrometer particulate matter (PM10), 1.10 (1.01, 1.20), sulfur dioxide (SO2), 1.28 (1.15, 1.42), ozone (O3), 1.18 (1.01, 1.37), and carbon monoxide (CO), 1.32 (1.15, 1.50). Joint exposure to air pollution was positively and linearly associated with the occurrence of carotid plaque, with low-density cholesterol (LDL-C) and mean arterial pressure (MAP) mediating 2.24 % and 4.28 % of the association, respectively. Conclusions: Long-term joint exposure to ambient air pollutants elevates the risk of developing carotid plaque. LDL-C and MAP suggest partial mediating effects of joint air pollution on carotid plaques. Our results emphasize the need to thoroughly evaluate various air pollutants concerning carotid plaque.http://www.sciencedirect.com/science/article/pii/S0147651325000910Carotid plaqueAir pollutionJoint exposureMediation effect |
| spellingShingle | Yunfei Li Ze Han Xiaoyu Zhao Yueruijing Liu Zhiyuan Wu Jinqi Wang Xia Li Xiuhua Guo Lixin Tao Association between joint exposure to ambient air pollutants and carotid plaque: The mediating role of cardiometabolic risk factors Ecotoxicology and Environmental Safety Carotid plaque Air pollution Joint exposure Mediation effect |
| title | Association between joint exposure to ambient air pollutants and carotid plaque: The mediating role of cardiometabolic risk factors |
| title_full | Association between joint exposure to ambient air pollutants and carotid plaque: The mediating role of cardiometabolic risk factors |
| title_fullStr | Association between joint exposure to ambient air pollutants and carotid plaque: The mediating role of cardiometabolic risk factors |
| title_full_unstemmed | Association between joint exposure to ambient air pollutants and carotid plaque: The mediating role of cardiometabolic risk factors |
| title_short | Association between joint exposure to ambient air pollutants and carotid plaque: The mediating role of cardiometabolic risk factors |
| title_sort | association between joint exposure to ambient air pollutants and carotid plaque the mediating role of cardiometabolic risk factors |
| topic | Carotid plaque Air pollution Joint exposure Mediation effect |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325000910 |
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