Effects of trigger-day progesterone in c-IVF/ICSI cycles on blastocyst culture outcomes
ObjectiveTo assess whether trigger-day progesterone (P) levels in conventional in vitro fertilization (c-IVF)/intracytoplasmic sperm injection (ICSI) cycles are associated with blastocyst culture outcomes.MethodsIn this retrospective analysis, 747 eligible patients (747 cycles) who adopted the gonad...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1496803/full |
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| author | Yating Sun Jia Wang Luyun Zhang Yanjun Chang Aizhen Zhu |
| author_facet | Yating Sun Jia Wang Luyun Zhang Yanjun Chang Aizhen Zhu |
| author_sort | Yating Sun |
| collection | DOAJ |
| description | ObjectiveTo assess whether trigger-day progesterone (P) levels in conventional in vitro fertilization (c-IVF)/intracytoplasmic sperm injection (ICSI) cycles are associated with blastocyst culture outcomes.MethodsIn this retrospective analysis, 747 eligible patients (747 cycles) who adopted the gonadotropin-releasing hormone (GnRH) antagonist protocol and underwent c-IVF/ICSI between January 2021 to June 2024 were recruited. The P cutoff values were 1.0 and 1.5 ng/ml when trigger-day serum P was measured, and 4177 day3 (D3) embryos for blastocyst culture were grouped according to trigger-day P levels. Furthermore, the effects of trigger-day P on blastocyst culture outcomes were evaluated.ResultsIn total, 747 cycles, 4177 D3 embryos for blastocyst culture were analyzed. After adjustments, multivariate logistic regression analysis revealed that compared with those in the normal level group, available blastocyst rate (adjusted OR, 0.780; 95% CI, 0.645-0.942; P=0.010) and D5 available blastocyst rate (adjusted OR, 0.736; 95% CI, 0.604-0.898; P=0.003) in the high level group were significantly reduced. Subgroup analysis showed that when female age was less than 35 years old, compared with that (36.30%) in the normal level group, the D5 available blastocyst rate (36.92%, adjusted OR, 0.744; 95% CI, 0.602-0.920; P=0.006) in the high level group was significantly reduced. In ICSI cycles, compared with that (28.69%) in the normal level group, the D5 available blastocyst rate (19.13%, adjusted OR, 0.369; 95% CI, 0.194-0.703; P=0.002) in the high level group was significantly decreased.Conclusion(s)This study demonstrated that in the c-IVF/ICSI population, the trigger-day slightly elevated P (1.0-1.5ng/ml) was not related to blastocyst culture outcomes, while the trigger-day elevated P (>1.5ng/ml) was an important factor affecting D5 available blastocyst rate, especially when the woman was younger than 35 years old or insemination type was ICSI. |
| format | Article |
| id | doaj-art-d3d35618acf3482c8450978faef8ac61 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-d3d35618acf3482c8450978faef8ac612025-02-12T05:14:59ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.14968031496803Effects of trigger-day progesterone in c-IVF/ICSI cycles on blastocyst culture outcomesYating SunJia WangLuyun ZhangYanjun ChangAizhen ZhuObjectiveTo assess whether trigger-day progesterone (P) levels in conventional in vitro fertilization (c-IVF)/intracytoplasmic sperm injection (ICSI) cycles are associated with blastocyst culture outcomes.MethodsIn this retrospective analysis, 747 eligible patients (747 cycles) who adopted the gonadotropin-releasing hormone (GnRH) antagonist protocol and underwent c-IVF/ICSI between January 2021 to June 2024 were recruited. The P cutoff values were 1.0 and 1.5 ng/ml when trigger-day serum P was measured, and 4177 day3 (D3) embryos for blastocyst culture were grouped according to trigger-day P levels. Furthermore, the effects of trigger-day P on blastocyst culture outcomes were evaluated.ResultsIn total, 747 cycles, 4177 D3 embryos for blastocyst culture were analyzed. After adjustments, multivariate logistic regression analysis revealed that compared with those in the normal level group, available blastocyst rate (adjusted OR, 0.780; 95% CI, 0.645-0.942; P=0.010) and D5 available blastocyst rate (adjusted OR, 0.736; 95% CI, 0.604-0.898; P=0.003) in the high level group were significantly reduced. Subgroup analysis showed that when female age was less than 35 years old, compared with that (36.30%) in the normal level group, the D5 available blastocyst rate (36.92%, adjusted OR, 0.744; 95% CI, 0.602-0.920; P=0.006) in the high level group was significantly reduced. In ICSI cycles, compared with that (28.69%) in the normal level group, the D5 available blastocyst rate (19.13%, adjusted OR, 0.369; 95% CI, 0.194-0.703; P=0.002) in the high level group was significantly decreased.Conclusion(s)This study demonstrated that in the c-IVF/ICSI population, the trigger-day slightly elevated P (1.0-1.5ng/ml) was not related to blastocyst culture outcomes, while the trigger-day elevated P (>1.5ng/ml) was an important factor affecting D5 available blastocyst rate, especially when the woman was younger than 35 years old or insemination type was ICSI.https://www.frontiersin.org/articles/10.3389/fendo.2025.1496803/fullconventional in vitro fertilization (c-IVF)intracytoplasmic sperm injection (ICSI)trigger-day progesterone (P)gonadotropin-releasing hormone (GnRH) antagonistavailable blastocyst ratetop-quality blastocyst rate |
| spellingShingle | Yating Sun Jia Wang Luyun Zhang Yanjun Chang Aizhen Zhu Effects of trigger-day progesterone in c-IVF/ICSI cycles on blastocyst culture outcomes Frontiers in Endocrinology conventional in vitro fertilization (c-IVF) intracytoplasmic sperm injection (ICSI) trigger-day progesterone (P) gonadotropin-releasing hormone (GnRH) antagonist available blastocyst rate top-quality blastocyst rate |
| title | Effects of trigger-day progesterone in c-IVF/ICSI cycles on blastocyst culture outcomes |
| title_full | Effects of trigger-day progesterone in c-IVF/ICSI cycles on blastocyst culture outcomes |
| title_fullStr | Effects of trigger-day progesterone in c-IVF/ICSI cycles on blastocyst culture outcomes |
| title_full_unstemmed | Effects of trigger-day progesterone in c-IVF/ICSI cycles on blastocyst culture outcomes |
| title_short | Effects of trigger-day progesterone in c-IVF/ICSI cycles on blastocyst culture outcomes |
| title_sort | effects of trigger day progesterone in c ivf icsi cycles on blastocyst culture outcomes |
| topic | conventional in vitro fertilization (c-IVF) intracytoplasmic sperm injection (ICSI) trigger-day progesterone (P) gonadotropin-releasing hormone (GnRH) antagonist available blastocyst rate top-quality blastocyst rate |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1496803/full |
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