Is preoperative imaging of sentinel lymph node in breast cancer necessary? A retrospective case control study
Objective: The necessity of preoperative lymphoscintigraphy before intraoperative sentinel lymph node (SLN) identification is still unclear. The aim of the present study was to evaluate the impact of SLN imaging on intraoperative SLN detection in breast cancer patients. Methods: Retrospective, compa...
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Elsevier
2025-02-01
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| Series: | Breast |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977624001875 |
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| author | Michael J. Reinhardt Björn Ohmstede Luz Angela Torres-de la Roche Rudy Leon De Wilde |
| author_facet | Michael J. Reinhardt Björn Ohmstede Luz Angela Torres-de la Roche Rudy Leon De Wilde |
| author_sort | Michael J. Reinhardt |
| collection | DOAJ |
| description | Objective: The necessity of preoperative lymphoscintigraphy before intraoperative sentinel lymph node (SLN) identification is still unclear. The aim of the present study was to evaluate the impact of SLN imaging on intraoperative SLN detection in breast cancer patients. Methods: Retrospective, comparative, single center study of patients with breast cancer stage pT1 and pT2 who underwent axillary staging. Group 1 included patients who underwent SLN extirpation without preoperative SLN imaging, and Group 2 included patients who underwent SLN imaging prior to surgery. Differences between groups were analyzed using T-test and chi-square test. Results: 926 (mean age: 61.45 years) patients received subdermal injection of radiolabeled nanocolloids between tumor and axilla. SLN was identified intraoperatively in 473 of 498 patients (94.98 %) in group 1, and in 415 of 428 patients (96.96 %) in group 2 (p = 0.129). Lymphoscintigraphy detected SLN in 407 of 428 (95.09 %) patients in group 2. Due to the additional SLN imaging in group 2, the time between radiotracer injection and start of surgery was significantly prolonged (p < 0.001). A reduction of applied activity from a median of 18 MBq in group 1 to a median of 12 MBq in group 2 had no negative effect on the SLN identification. Conclusion: Subdermal injection of radiolabeled nanocolloids between tumor and axilla allowed high intraoperative detection of SLN. Preoperative SLN imaging had no significant impact on the intraoperative detection but is a time-consuming and resource-intensive procedure. Prospective studies might provide further evidence to omit preoperative SLN imaging in patients with T1-2 invasive breast cancer and clinically negative axilla. |
| format | Article |
| id | doaj-art-d4252d52864e4dcd9a3cf067e4a2bbf1 |
| institution | Kabale University |
| issn | 1532-3080 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj-art-d4252d52864e4dcd9a3cf067e4a2bbf12025-02-12T05:30:35ZengElsevierBreast1532-30802025-02-0179103856Is preoperative imaging of sentinel lymph node in breast cancer necessary? A retrospective case control studyMichael J. Reinhardt0Björn Ohmstede1Luz Angela Torres-de la Roche2Rudy Leon De Wilde3Clinic for Nuclear Medicine, Pius Hospital, University Medicine Oldenburg, Carl von Ossietzky University Oldenburg, 26121, GermanyDepartment of Anaesthesiology and Intensive Care Medicine, Pius Hospital, University Medicine Oldenburg, Carl von Ossietzky University Oldenburg, 26121, GermanyUniversity Hospital for Gynecology, Pius Hospital, University Medicine Oldenburg, Carl von Ossietzky University Oldenburg, 26121, Germany; Corresponding author.University Hospital for Gynecology, Pius Hospital, University Medicine Oldenburg, Carl von Ossietzky University Oldenburg, 26121, GermanyObjective: The necessity of preoperative lymphoscintigraphy before intraoperative sentinel lymph node (SLN) identification is still unclear. The aim of the present study was to evaluate the impact of SLN imaging on intraoperative SLN detection in breast cancer patients. Methods: Retrospective, comparative, single center study of patients with breast cancer stage pT1 and pT2 who underwent axillary staging. Group 1 included patients who underwent SLN extirpation without preoperative SLN imaging, and Group 2 included patients who underwent SLN imaging prior to surgery. Differences between groups were analyzed using T-test and chi-square test. Results: 926 (mean age: 61.45 years) patients received subdermal injection of radiolabeled nanocolloids between tumor and axilla. SLN was identified intraoperatively in 473 of 498 patients (94.98 %) in group 1, and in 415 of 428 patients (96.96 %) in group 2 (p = 0.129). Lymphoscintigraphy detected SLN in 407 of 428 (95.09 %) patients in group 2. Due to the additional SLN imaging in group 2, the time between radiotracer injection and start of surgery was significantly prolonged (p < 0.001). A reduction of applied activity from a median of 18 MBq in group 1 to a median of 12 MBq in group 2 had no negative effect on the SLN identification. Conclusion: Subdermal injection of radiolabeled nanocolloids between tumor and axilla allowed high intraoperative detection of SLN. Preoperative SLN imaging had no significant impact on the intraoperative detection but is a time-consuming and resource-intensive procedure. Prospective studies might provide further evidence to omit preoperative SLN imaging in patients with T1-2 invasive breast cancer and clinically negative axilla.http://www.sciencedirect.com/science/article/pii/S0960977624001875Sentinel lymph nodeBreast cancerScintigraphy |
| spellingShingle | Michael J. Reinhardt Björn Ohmstede Luz Angela Torres-de la Roche Rudy Leon De Wilde Is preoperative imaging of sentinel lymph node in breast cancer necessary? A retrospective case control study Breast Sentinel lymph node Breast cancer Scintigraphy |
| title | Is preoperative imaging of sentinel lymph node in breast cancer necessary? A retrospective case control study |
| title_full | Is preoperative imaging of sentinel lymph node in breast cancer necessary? A retrospective case control study |
| title_fullStr | Is preoperative imaging of sentinel lymph node in breast cancer necessary? A retrospective case control study |
| title_full_unstemmed | Is preoperative imaging of sentinel lymph node in breast cancer necessary? A retrospective case control study |
| title_short | Is preoperative imaging of sentinel lymph node in breast cancer necessary? A retrospective case control study |
| title_sort | is preoperative imaging of sentinel lymph node in breast cancer necessary a retrospective case control study |
| topic | Sentinel lymph node Breast cancer Scintigraphy |
| url | http://www.sciencedirect.com/science/article/pii/S0960977624001875 |
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