Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures

Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures

Cognitive impairment is one of the many symptoms reported by individuals suffering from long-COVID and other post-viral infection disorders such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A common factor among these conditions is a sustained immune response and increased levels...

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Bibliographic Details
Main Authors: Noah Goshi, Doris Lam, Chandrakumar Bogguri, Vivek Kurien George, Aimy Sebastian, Jose Cadena, Nicole F. Leon, Nicholas R. Hum, Dina R. Weilhammer, Nicholas O. Fischer, Heather A. Enright
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
multi-electrode array
neuron networks
human iPSC derived neurons
inflammation
cytokine
long-COVID
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1512591/full
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