Experimental methods of portal hypertension studying
The aim of review. To present methods of studying of portal hypertension and means of its pharmacological treatment in experiment settings.Original positions. To study complex pathophysiological disorders, innate to portal hypertension, various pilot models providing complex evaluation and developme...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2010-04-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1506 |
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| _version_ | 1823860235266162688 |
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| author | D. V. Garbuzenko |
| author_facet | D. V. Garbuzenko |
| author_sort | D. V. Garbuzenko |
| collection | DOAJ |
| description | The aim of review. To present methods of studying of portal hypertension and means of its pharmacological treatment in experiment settings.Original positions. To study complex pathophysiological disorders, innate to portal hypertension, various pilot models providing complex evaluation and development of adequate treatment methods are used. Nowadays mechanisms of hyperdynamic circulatory status development are detailed on laboratory animals. Ex vivo studies gave physiological characteristic to the mediators causing splanchnic vasodilation and increasing of vascular tension in cirrhotic liver, and methods of molecular biology identified defects in signalling routes responsible for disorders of metabolism of these substances.Conclusion. In the last years application of various pilot models of portal hypertension promoted progress not only in understanding of pathophysiological mechanisms laying in its basis, but also development of new perspective methods of treatment. The further randomized controlled clinical studies will help to determine their safety and efficacy comparing to traditional treatment methods. |
| format | Article |
| id | doaj-art-d578b0f6e9254ed8839d077f77cdafee |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2010-04-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-d578b0f6e9254ed8839d077f77cdafee2025-02-10T16:14:30ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732010-04-012024121020Experimental methods of portal hypertension studyingD. V. Garbuzenko0Челябинская государственная медицинская академияThe aim of review. To present methods of studying of portal hypertension and means of its pharmacological treatment in experiment settings.Original positions. To study complex pathophysiological disorders, innate to portal hypertension, various pilot models providing complex evaluation and development of adequate treatment methods are used. Nowadays mechanisms of hyperdynamic circulatory status development are detailed on laboratory animals. Ex vivo studies gave physiological characteristic to the mediators causing splanchnic vasodilation and increasing of vascular tension in cirrhotic liver, and methods of molecular biology identified defects in signalling routes responsible for disorders of metabolism of these substances.Conclusion. In the last years application of various pilot models of portal hypertension promoted progress not only in understanding of pathophysiological mechanisms laying in its basis, but also development of new perspective methods of treatment. The further randomized controlled clinical studies will help to determine their safety and efficacy comparing to traditional treatment methods.https://www.gastro-j.ru/jour/article/view/1506portal hypertensionmodelingpathogenesistreatment |
| spellingShingle | D. V. Garbuzenko Experimental methods of portal hypertension studying Российский журнал гастроэнтерологии, гепатологии, колопроктологии portal hypertension modeling pathogenesis treatment |
| title | Experimental methods of portal hypertension studying |
| title_full | Experimental methods of portal hypertension studying |
| title_fullStr | Experimental methods of portal hypertension studying |
| title_full_unstemmed | Experimental methods of portal hypertension studying |
| title_short | Experimental methods of portal hypertension studying |
| title_sort | experimental methods of portal hypertension studying |
| topic | portal hypertension modeling pathogenesis treatment |
| url | https://www.gastro-j.ru/jour/article/view/1506 |
| work_keys_str_mv | AT dvgarbuzenko experimentalmethodsofportalhypertensionstudying |