Extracorporeal hyperoxygenation therapy (EHT) for CO poisoning: in vitro and in vivo feasibility of a full-scale batch system
Abstract Carbon monoxide (CO) poisoning is one of the most common causes of injury and death from poisoning. The primary objective of therapy is to eliminate CO from the patient as quickly as possible to prevent acute and long-term effects. The ideal treatment is hyperbaric oxygen in a pressure cham...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-84878-z |
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| author | Niklas B. Steuer Hannah Lüken Peter C. Schlanstein Matthias F. Menne Christiane Hoffmann Cavan Lübke Thomas Schmitz-Rode Sebastian Victor Jansen Ulrich Steinseifer Rüdger Kopp |
| author_facet | Niklas B. Steuer Hannah Lüken Peter C. Schlanstein Matthias F. Menne Christiane Hoffmann Cavan Lübke Thomas Schmitz-Rode Sebastian Victor Jansen Ulrich Steinseifer Rüdger Kopp |
| author_sort | Niklas B. Steuer |
| collection | DOAJ |
| description | Abstract Carbon monoxide (CO) poisoning is one of the most common causes of injury and death from poisoning. The primary objective of therapy is to eliminate CO from the patient as quickly as possible to prevent acute and long-term effects. The ideal treatment is hyperbaric oxygen in a pressure chamber. However, pressure chambers are scarce, and therefore, the most common treatment is normobaric oxygen (NBO), which, however, has limited efficacy. Here, we present a full-scale batch system for extracorporeal hyperoxygenation therapy (EHT), which facilitates CO elimination extracorporeally by increasing the dissolved oxygen concentration in the blood. The EHT was characterized in vitro, resulting in a minimum carboxyhemoglobin half-life of 3.26 ± 0.11 min. In large animal trials the EHT reduced the median carboxyhemoglobin half-life by 42% (29.77 min EHT vs. 70.8 min control (NBO)). However, the EHT also induced oscillations in hemodynamic pressures due to changes in the animals’ circulatory volume during operation. After optimization, the EHT could be a promising option for treating CO poisoning. |
| format | Article |
| id | doaj-art-d5ec0871ef0944c9a761c8b89f7d13cd |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-d5ec0871ef0944c9a761c8b89f7d13cd2025-02-09T12:30:58ZengNature PortfolioScientific Reports2045-23222025-02-0115111310.1038/s41598-024-84878-zExtracorporeal hyperoxygenation therapy (EHT) for CO poisoning: in vitro and in vivo feasibility of a full-scale batch systemNiklas B. Steuer0Hannah Lüken1Peter C. Schlanstein2Matthias F. Menne3Christiane Hoffmann4Cavan Lübke5Thomas Schmitz-Rode6Sebastian Victor Jansen7Ulrich Steinseifer8Rüdger Kopp9Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen UniversityDepartment of Intensive Care Medicine, Medical Faculty, RWTH Aachen UniversityDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen UniversityDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen UniversityDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen UniversityDepartment of Intensive Care Medicine, Medical Faculty, RWTH Aachen UniversityInstitute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen UniversityDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen UniversityDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen UniversityDepartment of Intensive Care Medicine, Medical Faculty, RWTH Aachen UniversityAbstract Carbon monoxide (CO) poisoning is one of the most common causes of injury and death from poisoning. The primary objective of therapy is to eliminate CO from the patient as quickly as possible to prevent acute and long-term effects. The ideal treatment is hyperbaric oxygen in a pressure chamber. However, pressure chambers are scarce, and therefore, the most common treatment is normobaric oxygen (NBO), which, however, has limited efficacy. Here, we present a full-scale batch system for extracorporeal hyperoxygenation therapy (EHT), which facilitates CO elimination extracorporeally by increasing the dissolved oxygen concentration in the blood. The EHT was characterized in vitro, resulting in a minimum carboxyhemoglobin half-life of 3.26 ± 0.11 min. In large animal trials the EHT reduced the median carboxyhemoglobin half-life by 42% (29.77 min EHT vs. 70.8 min control (NBO)). However, the EHT also induced oscillations in hemodynamic pressures due to changes in the animals’ circulatory volume during operation. After optimization, the EHT could be a promising option for treating CO poisoning.https://doi.org/10.1038/s41598-024-84878-z |
| spellingShingle | Niklas B. Steuer Hannah Lüken Peter C. Schlanstein Matthias F. Menne Christiane Hoffmann Cavan Lübke Thomas Schmitz-Rode Sebastian Victor Jansen Ulrich Steinseifer Rüdger Kopp Extracorporeal hyperoxygenation therapy (EHT) for CO poisoning: in vitro and in vivo feasibility of a full-scale batch system Scientific Reports |
| title | Extracorporeal hyperoxygenation therapy (EHT) for CO poisoning: in vitro and in vivo feasibility of a full-scale batch system |
| title_full | Extracorporeal hyperoxygenation therapy (EHT) for CO poisoning: in vitro and in vivo feasibility of a full-scale batch system |
| title_fullStr | Extracorporeal hyperoxygenation therapy (EHT) for CO poisoning: in vitro and in vivo feasibility of a full-scale batch system |
| title_full_unstemmed | Extracorporeal hyperoxygenation therapy (EHT) for CO poisoning: in vitro and in vivo feasibility of a full-scale batch system |
| title_short | Extracorporeal hyperoxygenation therapy (EHT) for CO poisoning: in vitro and in vivo feasibility of a full-scale batch system |
| title_sort | extracorporeal hyperoxygenation therapy eht for co poisoning in vitro and in vivo feasibility of a full scale batch system |
| url | https://doi.org/10.1038/s41598-024-84878-z |
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