The significance of focal pattern in hypsarrhythmia
Introduction: Infantile Epileptic Spasms Syndrome (IESS) presents a therapeutic challenge and is frequently associated with developmental delay. It is characterized by seizures and hypsarrhythmia on the EEG and has multiple etiologies that influence therapeutic decisions. Severity of hypsarrhythmia...
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Elsevier
2025-03-01
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| Series: | Brain Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666459325000083 |
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| author | Anna Wiedemann Birgit Stark Gudrun Gröppel |
| author_facet | Anna Wiedemann Birgit Stark Gudrun Gröppel |
| author_sort | Anna Wiedemann |
| collection | DOAJ |
| description | Introduction: Infantile Epileptic Spasms Syndrome (IESS) presents a therapeutic challenge and is frequently associated with developmental delay. It is characterized by seizures and hypsarrhythmia on the EEG and has multiple etiologies that influence therapeutic decisions. Severity of hypsarrhythmia serves as an indicator for evaluating treatment efficacy. However, the correlation between clinical symptoms, EEG patterns, and cerebral lesions requires further investigation. Methods: Eighteen infants diagnosed with IESS underwent video-EEG monitoring and MRI. Hypsarrhythmia severity was assessed using the Kramer et al. scoring system. Clinical semiology was evaluated for lateralizing features. Statistical analyses were conducted to examine correlations between EEG findings, clinical symptoms, and cerebral lesions. Results: All infants exhibited hypsarrhythmia and 72.3 % presented with cerebral lesions, predominantly bilateral. Clinical symptoms frequently indicated lateralization, whereas EEG findings demonstrated lateralization in only 22.2 % of cases. No significant correlation was identified between hypsarrhythmia patterns and clinical symptoms or lesions. The severity of hypsarrhythmia was not a reliable predictor of the underlying etiology. Conclusion: This study found no association between hypsarrhythmic patterns and focal semiology or lesions. Given the heterogeneity of IESS, individualized diagnostic approaches remain essential. While the hypsarrhythmia score enhances the comparability of EEG patterns, its utility in determining the underlying etiology appears to be limited. |
| format | Article |
| id | doaj-art-d607c894683d4549be0473ab9eec013d |
| institution | Kabale University |
| issn | 2666-4593 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Disorders |
| spelling | doaj-art-d607c894683d4549be0473ab9eec013d2025-02-08T05:01:19ZengElsevierBrain Disorders2666-45932025-03-0117100188The significance of focal pattern in hypsarrhythmiaAnna Wiedemann0Birgit Stark1Gudrun Gröppel2Department of Paediatrics and Adolescent Medicine, Johannes Kepler University Linz, Krankenhausstraße 26-30, 4020 Linz, AustriaDepartment of Paediatrics and Adolescent Medicine, Johannes Kepler University Linz, Krankenhausstraße 26-30, 4020 Linz, AustriaCorresponding author.; Department of Paediatrics and Adolescent Medicine, Johannes Kepler University Linz, Krankenhausstraße 26-30, 4020 Linz, AustriaIntroduction: Infantile Epileptic Spasms Syndrome (IESS) presents a therapeutic challenge and is frequently associated with developmental delay. It is characterized by seizures and hypsarrhythmia on the EEG and has multiple etiologies that influence therapeutic decisions. Severity of hypsarrhythmia serves as an indicator for evaluating treatment efficacy. However, the correlation between clinical symptoms, EEG patterns, and cerebral lesions requires further investigation. Methods: Eighteen infants diagnosed with IESS underwent video-EEG monitoring and MRI. Hypsarrhythmia severity was assessed using the Kramer et al. scoring system. Clinical semiology was evaluated for lateralizing features. Statistical analyses were conducted to examine correlations between EEG findings, clinical symptoms, and cerebral lesions. Results: All infants exhibited hypsarrhythmia and 72.3 % presented with cerebral lesions, predominantly bilateral. Clinical symptoms frequently indicated lateralization, whereas EEG findings demonstrated lateralization in only 22.2 % of cases. No significant correlation was identified between hypsarrhythmia patterns and clinical symptoms or lesions. The severity of hypsarrhythmia was not a reliable predictor of the underlying etiology. Conclusion: This study found no association between hypsarrhythmic patterns and focal semiology or lesions. Given the heterogeneity of IESS, individualized diagnostic approaches remain essential. While the hypsarrhythmia score enhances the comparability of EEG patterns, its utility in determining the underlying etiology appears to be limited.http://www.sciencedirect.com/science/article/pii/S2666459325000083HypsarrhythmiaInfantile spasmsInfantile epileptic spasms syndrome |
| spellingShingle | Anna Wiedemann Birgit Stark Gudrun Gröppel The significance of focal pattern in hypsarrhythmia Brain Disorders Hypsarrhythmia Infantile spasms Infantile epileptic spasms syndrome |
| title | The significance of focal pattern in hypsarrhythmia |
| title_full | The significance of focal pattern in hypsarrhythmia |
| title_fullStr | The significance of focal pattern in hypsarrhythmia |
| title_full_unstemmed | The significance of focal pattern in hypsarrhythmia |
| title_short | The significance of focal pattern in hypsarrhythmia |
| title_sort | significance of focal pattern in hypsarrhythmia |
| topic | Hypsarrhythmia Infantile spasms Infantile epileptic spasms syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S2666459325000083 |
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