Meta-analysis and systematic review for the genetic basis of cleft lip and palate
Cleft lip and palate (CLP) are a usually inherited anomaly described as a gap in the oral cavity's upper lip and/or roof. The etiology of CLP involves both genetic and environmental factors. The current study aimed to examine the genetic basis of nonsyndromic (NS) CLP (NSCL/P) and its associati...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221242682400188X |
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| author | Wafaa Yahia Alghonemy Mohamed Gaber Ashmawy |
| author_facet | Wafaa Yahia Alghonemy Mohamed Gaber Ashmawy |
| author_sort | Wafaa Yahia Alghonemy |
| collection | DOAJ |
| description | Cleft lip and palate (CLP) are a usually inherited anomaly described as a gap in the oral cavity's upper lip and/or roof. The etiology of CLP involves both genetic and environmental factors. The current study aimed to examine the genetic basis of nonsyndromic (NS) CLP (NSCL/P) and its association with specific genetic polymorphisms. We conducted a meta-analysis and systematic review of seven articles, which provided information on the correlation between genes and NSCL/P risk.Our results proved that the MTHFR c.677C > T polymorphism was correlated with the risk of NSCL/P, favoring the control group in the CC genotype and the cases group in the CT genotype. The TT genotype favored the control group. Additionally, the MTHFD1 1958G > A polymorphism was correlated with the high NSCL/P risk in children. However, the MTHFR C677T polymorphism did not show a significant correlation with NSCL/P risk in the analysis, although it was correlated with the high risk in specific populations.These results contribute to our knowledge about the genetic causes of NSCL/P and highlight the importance of specific genetic polymorphisms in its development. Further research is needed to explore the genetic mechanisms underlying NSCL/P in different populations and to elucidate its implications for diagnosis, treatment, and prevention strategies. |
| format | Article |
| id | doaj-art-d660043387414b618e85db95a0e5e292 |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-d660043387414b618e85db95a0e5e2922025-02-09T05:00:13ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682025-01-01151146152Meta-analysis and systematic review for the genetic basis of cleft lip and palateWafaa Yahia Alghonemy0Mohamed Gaber Ashmawy1Basic Dental Sciences, Faculty of Dentistry, Zarqa University, PO Box 2000, Zarqa, 13110, Jordan; Oral Biology Department, Faculty of Dentistry, Tanta University, Egypt; Corresponding author. Basic Dental Sciences, Faculty of Dentistry, Zarqa University, PO Box 2000, Zarqa, 13110 Jordan.Researcher at the Egyptian Ministry of Health, PO Box 2111, Tanta, EgyptCleft lip and palate (CLP) are a usually inherited anomaly described as a gap in the oral cavity's upper lip and/or roof. The etiology of CLP involves both genetic and environmental factors. The current study aimed to examine the genetic basis of nonsyndromic (NS) CLP (NSCL/P) and its association with specific genetic polymorphisms. We conducted a meta-analysis and systematic review of seven articles, which provided information on the correlation between genes and NSCL/P risk.Our results proved that the MTHFR c.677C > T polymorphism was correlated with the risk of NSCL/P, favoring the control group in the CC genotype and the cases group in the CT genotype. The TT genotype favored the control group. Additionally, the MTHFD1 1958G > A polymorphism was correlated with the high NSCL/P risk in children. However, the MTHFR C677T polymorphism did not show a significant correlation with NSCL/P risk in the analysis, although it was correlated with the high risk in specific populations.These results contribute to our knowledge about the genetic causes of NSCL/P and highlight the importance of specific genetic polymorphisms in its development. Further research is needed to explore the genetic mechanisms underlying NSCL/P in different populations and to elucidate its implications for diagnosis, treatment, and prevention strategies.http://www.sciencedirect.com/science/article/pii/S221242682400188XGeneticsCleft palateCleft lipNon-syndromic cleftCandidate genesMTHFR |
| spellingShingle | Wafaa Yahia Alghonemy Mohamed Gaber Ashmawy Meta-analysis and systematic review for the genetic basis of cleft lip and palate Journal of Oral Biology and Craniofacial Research Genetics Cleft palate Cleft lip Non-syndromic cleft Candidate genes MTHFR |
| title | Meta-analysis and systematic review for the genetic basis of cleft lip and palate |
| title_full | Meta-analysis and systematic review for the genetic basis of cleft lip and palate |
| title_fullStr | Meta-analysis and systematic review for the genetic basis of cleft lip and palate |
| title_full_unstemmed | Meta-analysis and systematic review for the genetic basis of cleft lip and palate |
| title_short | Meta-analysis and systematic review for the genetic basis of cleft lip and palate |
| title_sort | meta analysis and systematic review for the genetic basis of cleft lip and palate |
| topic | Genetics Cleft palate Cleft lip Non-syndromic cleft Candidate genes MTHFR |
| url | http://www.sciencedirect.com/science/article/pii/S221242682400188X |
| work_keys_str_mv | AT wafaayahiaalghonemy metaanalysisandsystematicreviewforthegeneticbasisofcleftlipandpalate AT mohamedgaberashmawy metaanalysisandsystematicreviewforthegeneticbasisofcleftlipandpalate |