The effect of Clostridium difficile infection on the course of liver cirrhosis

Aim of investigation. To estimate the frequency of Clostridium difficile (C. difficile) infection and its effect on severity and pattern of complications at the compensated liver cirrhosis (LC). Material and methods. The original study included overall 47 patients with decompensated LC (Child-Pugh c...

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Main Authors: A. A. Driga, M. V. Mayevskaya, V. T. Ivashkin
Format: Article
Language:Russian
Published: Gastro LLC 2018-08-01
Series:Российский журнал гастроэнтерологии, гепатологии, колопроктологии
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Online Access:https://www.gastro-j.ru/jour/article/view/134
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author A. A. Driga
M. V. Mayevskaya
V. T. Ivashkin
author_facet A. A. Driga
M. V. Mayevskaya
V. T. Ivashkin
author_sort A. A. Driga
collection DOAJ
description Aim of investigation. To estimate the frequency of Clostridium difficile (C. difficile) infection and its effect on severity and pattern of complications at the compensated liver cirrhosis (LC). Material and methods. The original study included overall 47 patients with decompensated LC (Child-Pugh class B - 27 patients and class C - 20 patients). All patients underwent clinical interviewing with assessment of past history, daily blood pressure (BP) measurement with calculation of the mean blood pressure level, blood tests, ECG, abdominal ultrasound, esophagogastroduodenoscopy, echocardiography, chest X-ray, lactulose hydrogen breath test, Clostridium difficile ELISA stool test. Results. Clostridium difficile infection was found in 26 (55.3%) of 47 patients with decompensated LC. Of patients with alcoholic LC the mean Maddrey score in Clostridium difficile-infected subgroup was significantly higher than the score of non-infected patients. For the last 6 months prior to the study enrollment 50% of patients with Clostridium difficile infection were hospitalized and received antibiotics significantly more frequently. Metronidazole was prescribed more frequently to Clostridium difficile-infected patients (92.3% versus 9.5%; р
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series Российский журнал гастроэнтерологии, гепатологии, колопроктологии
spelling doaj-art-d76e480c5a27421b8d1856a42e06aa552025-02-10T16:14:29ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-01272445310.22416/1382-4376-2017-27-2-44-53134The effect of Clostridium difficile infection on the course of liver cirrhosisA. A. Driga0M. V. Mayevskaya1V. T. Ivashkin2The State Education Institution of Higher Professional Training «The First Sechenov Moscow State Medical University»The State Education Institution of Higher Professional Training «The First Sechenov Moscow State Medical University»The State Education Institution of Higher Professional Training «The First Sechenov Moscow State Medical University»Aim of investigation. To estimate the frequency of Clostridium difficile (C. difficile) infection and its effect on severity and pattern of complications at the compensated liver cirrhosis (LC). Material and methods. The original study included overall 47 patients with decompensated LC (Child-Pugh class B - 27 patients and class C - 20 patients). All patients underwent clinical interviewing with assessment of past history, daily blood pressure (BP) measurement with calculation of the mean blood pressure level, blood tests, ECG, abdominal ultrasound, esophagogastroduodenoscopy, echocardiography, chest X-ray, lactulose hydrogen breath test, Clostridium difficile ELISA stool test. Results. Clostridium difficile infection was found in 26 (55.3%) of 47 patients with decompensated LC. Of patients with alcoholic LC the mean Maddrey score in Clostridium difficile-infected subgroup was significantly higher than the score of non-infected patients. For the last 6 months prior to the study enrollment 50% of patients with Clostridium difficile infection were hospitalized and received antibiotics significantly more frequently. Metronidazole was prescribed more frequently to Clostridium difficile-infected patients (92.3% versus 9.5%; рhttps://www.gastro-j.ru/jour/article/view/134цирроз печениклостридиальная инфекцияметронидазол
spellingShingle A. A. Driga
M. V. Mayevskaya
V. T. Ivashkin
The effect of Clostridium difficile infection on the course of liver cirrhosis
Российский журнал гастроэнтерологии, гепатологии, колопроктологии
цирроз печени
клостридиальная инфекция
метронидазол
title The effect of Clostridium difficile infection on the course of liver cirrhosis
title_full The effect of Clostridium difficile infection on the course of liver cirrhosis
title_fullStr The effect of Clostridium difficile infection on the course of liver cirrhosis
title_full_unstemmed The effect of Clostridium difficile infection on the course of liver cirrhosis
title_short The effect of Clostridium difficile infection on the course of liver cirrhosis
title_sort effect of clostridium difficile infection on the course of liver cirrhosis
topic цирроз печени
клостридиальная инфекция
метронидазол
url https://www.gastro-j.ru/jour/article/view/134
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