Comparing the Effect of Intrathecal Injection of Pethidine with That of Bupivacaine on Hemodynamics in Hip Surgery: A Double Blinded Clinical Trial
Background: The use of regional anesthesia for lower limb orthopedic surgery is preferable to general anesthesia. In some studies comparing regional anesthesia and general anesthesia, the one-month mortality of patients undergoing regional surgery was significantly lower. Given the relative advanta...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2024-10-01
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| Series: | Archives of Anesthesia and Critical Care |
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| Online Access: | https://aacc.tums.ac.ir/index.php/aacc/article/view/1027 |
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| author | Seyed Babak Mojaveraghili Sina Hassannasab Mansour Deylami Tahereh Chavoshi Avasadat Mirkatouli Nasser Behnampour |
| author_facet | Seyed Babak Mojaveraghili Sina Hassannasab Mansour Deylami Tahereh Chavoshi Avasadat Mirkatouli Nasser Behnampour |
| author_sort | Seyed Babak Mojaveraghili |
| collection | DOAJ |
| description |
Background: The use of regional anesthesia for lower limb orthopedic surgery is preferable to general anesthesia. In some studies comparing regional anesthesia and general anesthesia, the one-month mortality of patients undergoing regional surgery was significantly lower. Given the relative advantages observed about intrathecal injection of pethidine, including fewer side effects, and longer postoperative analgesia, in combination with effective sensory, motor, and sympathetic blocks, we sought to compare the influence of intrathecal injection of pethidine and bupivacaine on the hemodynamics of patients.
Methods: In this double blind randomized parallel trial, patients undergoing surgery with femoral and hip fractures, were divided into two groups. In the first group bupivacaine and in the second group pethidine were used for spinal anesthesia. Hemodynamic changes were examined and recorded during surgery. The results were analyzed by SPSS18 software
Results: 67 patients undergoing surgery with femoral and hip fractures, were divided into two groups of 30 and 37 individuals. The mean heart rate in patients with a high risk of surgery was higher in the group receiving pethidine compared to the group of bupivacaine, with a Cohen's effect size of 0.294. This effect size is evaluated as average, while the rate of mean arterial pressure with Cohen's effect size of 0.511 was evaluated as large.
Conclusion: Pethidine can be a good alternative to bupivacaine, especially in patients at high risk of surgery, given its hemodynamic stability.
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| format | Article |
| id | doaj-art-d7e4908dbfbb4e038f42c5eef56e0f94 |
| institution | Kabale University |
| issn | 2423-5849 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Archives of Anesthesia and Critical Care |
| spelling | doaj-art-d7e4908dbfbb4e038f42c5eef56e0f942025-02-09T08:53:26ZengTehran University of Medical SciencesArchives of Anesthesia and Critical Care2423-58492024-10-0111110.18502/aacc.v11i1.17494Comparing the Effect of Intrathecal Injection of Pethidine with That of Bupivacaine on Hemodynamics in Hip Surgery: A Double Blinded Clinical TrialSeyed Babak Mojaveraghili0Sina Hassannasab1Mansour Deylami2Tahereh Chavoshi3Avasadat Mirkatouli4Nasser Behnampour5Department of Anesthesiology, 5 Azar Hospital, Golestan University of Medical Sciences, Gorgan, Iran.Department of Anesthesiology and Pain Medicine, Imam Hossain Hospital,, Shahid Beheshti Medical University, Tehran, Iran.Department of Anesthesiology, 5 Azar Hospital, Golestan University of Medical Sciences, Gorgan, Iran.Department of Anesthesiology, Ali Asghar Hospital, Iran University of Medical Sciences, Tehran, Iran.Department of Anesthesiology, 5 Azar Hospital, Golestan University of Medical Sciences, Gorgan, Iran.Department of Biostatistics and Epidemiology, Health Management and Social Development Research Center, Faculty of Health, Golestan University of Medical Sciences, Golestan, Iran. Background: The use of regional anesthesia for lower limb orthopedic surgery is preferable to general anesthesia. In some studies comparing regional anesthesia and general anesthesia, the one-month mortality of patients undergoing regional surgery was significantly lower. Given the relative advantages observed about intrathecal injection of pethidine, including fewer side effects, and longer postoperative analgesia, in combination with effective sensory, motor, and sympathetic blocks, we sought to compare the influence of intrathecal injection of pethidine and bupivacaine on the hemodynamics of patients. Methods: In this double blind randomized parallel trial, patients undergoing surgery with femoral and hip fractures, were divided into two groups. In the first group bupivacaine and in the second group pethidine were used for spinal anesthesia. Hemodynamic changes were examined and recorded during surgery. The results were analyzed by SPSS18 software Results: 67 patients undergoing surgery with femoral and hip fractures, were divided into two groups of 30 and 37 individuals. The mean heart rate in patients with a high risk of surgery was higher in the group receiving pethidine compared to the group of bupivacaine, with a Cohen's effect size of 0.294. This effect size is evaluated as average, while the rate of mean arterial pressure with Cohen's effect size of 0.511 was evaluated as large. Conclusion: Pethidine can be a good alternative to bupivacaine, especially in patients at high risk of surgery, given its hemodynamic stability. https://aacc.tums.ac.ir/index.php/aacc/article/view/1027Spinal anesthesiaPethidineBupivacaineHemodynamicsOrthopedicsAnesthesia |
| spellingShingle | Seyed Babak Mojaveraghili Sina Hassannasab Mansour Deylami Tahereh Chavoshi Avasadat Mirkatouli Nasser Behnampour Comparing the Effect of Intrathecal Injection of Pethidine with That of Bupivacaine on Hemodynamics in Hip Surgery: A Double Blinded Clinical Trial Archives of Anesthesia and Critical Care Spinal anesthesia Pethidine Bupivacaine Hemodynamics Orthopedics Anesthesia |
| title | Comparing the Effect of Intrathecal Injection of Pethidine with That of Bupivacaine on Hemodynamics in Hip Surgery: A Double Blinded Clinical Trial |
| title_full | Comparing the Effect of Intrathecal Injection of Pethidine with That of Bupivacaine on Hemodynamics in Hip Surgery: A Double Blinded Clinical Trial |
| title_fullStr | Comparing the Effect of Intrathecal Injection of Pethidine with That of Bupivacaine on Hemodynamics in Hip Surgery: A Double Blinded Clinical Trial |
| title_full_unstemmed | Comparing the Effect of Intrathecal Injection of Pethidine with That of Bupivacaine on Hemodynamics in Hip Surgery: A Double Blinded Clinical Trial |
| title_short | Comparing the Effect of Intrathecal Injection of Pethidine with That of Bupivacaine on Hemodynamics in Hip Surgery: A Double Blinded Clinical Trial |
| title_sort | comparing the effect of intrathecal injection of pethidine with that of bupivacaine on hemodynamics in hip surgery a double blinded clinical trial |
| topic | Spinal anesthesia Pethidine Bupivacaine Hemodynamics Orthopedics Anesthesia |
| url | https://aacc.tums.ac.ir/index.php/aacc/article/view/1027 |
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