Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy
Abstract The genetic risk for hypertensive disorders of pregnancy is linked with the development of atherosclerotic cardiovascular disease. However, the effects of lifestyle and metabolic syndrome on atherosclerotic cardiovascular disease have not been evaluated. Here, we assess the long-term associ...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56107-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861847374168064 |
|---|---|
| author | Sang‑Hyuk Jung Haemin Kim Young Mi Jung Manu Shivakumar Brenda Xiao Jaeyoung Kim Beomjin Jang Jae-Seung Yun Hong-Hee Won Chan-Wook Park Joong Shin Park Jong Kwan Jun Dokyoon Kim Seung Mi Lee |
| author_facet | Sang‑Hyuk Jung Haemin Kim Young Mi Jung Manu Shivakumar Brenda Xiao Jaeyoung Kim Beomjin Jang Jae-Seung Yun Hong-Hee Won Chan-Wook Park Joong Shin Park Jong Kwan Jun Dokyoon Kim Seung Mi Lee |
| author_sort | Sang‑Hyuk Jung |
| collection | DOAJ |
| description | Abstract The genetic risk for hypertensive disorders of pregnancy is linked with the development of atherosclerotic cardiovascular disease. However, the effects of lifestyle and metabolic syndrome on atherosclerotic cardiovascular disease have not been evaluated. Here, we assess the long-term association between these factors and atherosclerotic cardiovascular disease in women with genetic risk for hypertensive disorders of pregnancy. We evaluate the genetic risk for hypertensive disorders of pregnancy using a genome-wide polygenic risk score derived from a large-scale GWAS. The incidence of atherosclerotic cardiovascular disease is evaluated according to genetic risk, lifestyle, and metabolic syndrome. Individuals with a very high genetic risk for hypertensive disorders of pregnancy have a 53.0% higher chance of developing atherosclerotic cardiovascular disease than those with a low genetic risk. However, the risk of developing atherosclerotic cardiovascular disease is reduced by up to 64.6% through the maintenance of an ideal metabolic syndrome status and a healthy lifestyle in the high genetic risk group (top 20%), and by up to 65.4% in the low genetic risk group (bottom 20%). These findings emphasize that maintaining a healthy lifestyle in women is equally effective at reducing the risk of atherosclerotic cardiovascular disease independent of genetic risk for hypertensive disorders of pregnancy. |
| format | Article |
| id | doaj-art-d86b476b61664366b0b144fd56dc3e93 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-d86b476b61664366b0b144fd56dc3e932025-02-09T12:44:05ZengNature PortfolioNature Communications2041-17232025-02-0116111110.1038/s41467-025-56107-2Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancySang‑Hyuk Jung0Haemin Kim1Young Mi Jung2Manu Shivakumar3Brenda Xiao4Jaeyoung Kim5Beomjin Jang6Jae-Seung Yun7Hong-Hee Won8Chan-Wook Park9Joong Shin Park10Jong Kwan Jun11Dokyoon Kim12Seung Mi Lee13Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of PennsylvaniaDepartment of Obstetrics and Gynecology, Seoul National University College of MedicineDepartment of Obstetrics and Gynecology, Seoul National University College of MedicineDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of PennsylvaniaDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of PennsylvaniaSamsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical CenterSamsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical CenterDepartment of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of KoreaSamsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical CenterDepartment of Obstetrics and Gynecology, Seoul National University College of MedicineDepartment of Obstetrics and Gynecology, Seoul National University College of MedicineDepartment of Obstetrics and Gynecology, Seoul National University College of MedicineDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of PennsylvaniaDepartment of Obstetrics and Gynecology, Seoul National University College of MedicineAbstract The genetic risk for hypertensive disorders of pregnancy is linked with the development of atherosclerotic cardiovascular disease. However, the effects of lifestyle and metabolic syndrome on atherosclerotic cardiovascular disease have not been evaluated. Here, we assess the long-term association between these factors and atherosclerotic cardiovascular disease in women with genetic risk for hypertensive disorders of pregnancy. We evaluate the genetic risk for hypertensive disorders of pregnancy using a genome-wide polygenic risk score derived from a large-scale GWAS. The incidence of atherosclerotic cardiovascular disease is evaluated according to genetic risk, lifestyle, and metabolic syndrome. Individuals with a very high genetic risk for hypertensive disorders of pregnancy have a 53.0% higher chance of developing atherosclerotic cardiovascular disease than those with a low genetic risk. However, the risk of developing atherosclerotic cardiovascular disease is reduced by up to 64.6% through the maintenance of an ideal metabolic syndrome status and a healthy lifestyle in the high genetic risk group (top 20%), and by up to 65.4% in the low genetic risk group (bottom 20%). These findings emphasize that maintaining a healthy lifestyle in women is equally effective at reducing the risk of atherosclerotic cardiovascular disease independent of genetic risk for hypertensive disorders of pregnancy.https://doi.org/10.1038/s41467-025-56107-2 |
| spellingShingle | Sang‑Hyuk Jung Haemin Kim Young Mi Jung Manu Shivakumar Brenda Xiao Jaeyoung Kim Beomjin Jang Jae-Seung Yun Hong-Hee Won Chan-Wook Park Joong Shin Park Jong Kwan Jun Dokyoon Kim Seung Mi Lee Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy Nature Communications |
| title | Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy |
| title_full | Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy |
| title_fullStr | Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy |
| title_full_unstemmed | Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy |
| title_short | Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy |
| title_sort | healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy |
| url | https://doi.org/10.1038/s41467-025-56107-2 |
| work_keys_str_mv | AT sanghyukjung healthylifestylereducescardiovascularriskinwomenwithgeneticpredispositiontohypertensivedisordersofpregnancy AT haeminkim healthylifestylereducescardiovascularriskinwomenwithgeneticpredispositiontohypertensivedisordersofpregnancy AT youngmijung healthylifestylereducescardiovascularriskinwomenwithgeneticpredispositiontohypertensivedisordersofpregnancy AT manushivakumar healthylifestylereducescardiovascularriskinwomenwithgeneticpredispositiontohypertensivedisordersofpregnancy AT brendaxiao healthylifestylereducescardiovascularriskinwomenwithgeneticpredispositiontohypertensivedisordersofpregnancy AT jaeyoungkim healthylifestylereducescardiovascularriskinwomenwithgeneticpredispositiontohypertensivedisordersofpregnancy AT beomjinjang healthylifestylereducescardiovascularriskinwomenwithgeneticpredispositiontohypertensivedisordersofpregnancy AT jaeseungyun healthylifestylereducescardiovascularriskinwomenwithgeneticpredispositiontohypertensivedisordersofpregnancy AT hongheewon healthylifestylereducescardiovascularriskinwomenwithgeneticpredispositiontohypertensivedisordersofpregnancy AT chanwookpark healthylifestylereducescardiovascularriskinwomenwithgeneticpredispositiontohypertensivedisordersofpregnancy AT joongshinpark healthylifestylereducescardiovascularriskinwomenwithgeneticpredispositiontohypertensivedisordersofpregnancy AT jongkwanjun healthylifestylereducescardiovascularriskinwomenwithgeneticpredispositiontohypertensivedisordersofpregnancy AT dokyoonkim healthylifestylereducescardiovascularriskinwomenwithgeneticpredispositiontohypertensivedisordersofpregnancy AT seungmilee healthylifestylereducescardiovascularriskinwomenwithgeneticpredispositiontohypertensivedisordersofpregnancy |