Lipedema: Clinical Features, Diagnosis, and Management

Lipedema is an adipose tissue disorder that principally affects women and is frequently misidentified as obesity or lymphedema. There have been relatively few studies that have precisely defined the pathogenesis, epidemiology, and treatment approaches for lipedema. However, successfully recognizing...

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Main Authors: Hatan Hisham Mortada, Abdulmalek W. Alhithlool, Nouf Z. AlBattal, Rashika K. Shetty, Ghaleb A. AL-Mekhlafi, Joon Pio Hong, Feras Alshomer
Format: Article
Language:English
Published: Thieme Medical Publishers, Inc.
Series:Archives of Plastic Surgery
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/a-2530-5875
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author Hatan Hisham Mortada
Abdulmalek W. Alhithlool
Nouf Z. AlBattal
Rashika K. Shetty
Ghaleb A. AL-Mekhlafi
Joon Pio Hong
Feras Alshomer
author_facet Hatan Hisham Mortada
Abdulmalek W. Alhithlool
Nouf Z. AlBattal
Rashika K. Shetty
Ghaleb A. AL-Mekhlafi
Joon Pio Hong
Feras Alshomer
author_sort Hatan Hisham Mortada
collection DOAJ
description Lipedema is an adipose tissue disorder that principally affects women and is frequently misidentified as obesity or lymphedema. There have been relatively few studies that have precisely defined the pathogenesis, epidemiology, and treatment approaches for lipedema. However, successfully recognizing lipedema as a distinct condition is important for proper management. This review aimed to examine the existing literature on the epidemiology, pathogenesis, clinical presentation, differential diagnosis, and treatments for lipedema. The current research indicates that lipedema appears to be a clinical entity related to genetic factors and fat distribution, although distinct from lymphedema and obesity. Some available treatments include complex decongestive physiotherapy, liposuction, and laser-assisted lipolysis. The management of lipedema is complex and differs from that of lymphedema. Further high-quality randomized controlled trials are urgently needed to continue advancing our understanding of this often neglected disease and exploring optimal medical and surgical treatment regimens tailored specifically for lipedema patients. In summary, despite frequent misdiagnosis, enhanced recognition, and research into customized therapeutic strategies for this poorly characterized but likely underdiagnosed disorder represent promising steps forward.
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institution Kabale University
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language English
publisher Thieme Medical Publishers, Inc.
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series Archives of Plastic Surgery
spelling doaj-art-d8efe3a49a6244e3b25e3e7d3469397d2025-02-12T01:13:40ZengThieme Medical Publishers, Inc.Archives of Plastic Surgery2234-61632234-617110.1055/a-2530-5875Lipedema: Clinical Features, Diagnosis, and ManagementHatan Hisham Mortada0Abdulmalek W. Alhithlool1Nouf Z. AlBattal2Rashika K. Shetty3Ghaleb A. AL-Mekhlafi4Joon Pio Hong5Feras Alshomer6Division of Plastic Surgery, Department of Surgery, King Saud University Medical City, Riyadh, Saudi ArabiaCollege of Medicine, King Faisal University, Al Ahsa, Saudi ArabiaCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi ArabiaSchool of Mediicne, University of Minnesota, Minneapolis, United StatesCollege of Medicine, Fakeeh College for Medical Sciences, Jeddah, Saudi ArabiaDivision of Plastic Surgery, Department of Surgery, Asan Medical Center, Songpa-gu, Korea (the Republic of)Department of Plastic and Reconstructive Surgery, Asan Medical CenterLipedema is an adipose tissue disorder that principally affects women and is frequently misidentified as obesity or lymphedema. There have been relatively few studies that have precisely defined the pathogenesis, epidemiology, and treatment approaches for lipedema. However, successfully recognizing lipedema as a distinct condition is important for proper management. This review aimed to examine the existing literature on the epidemiology, pathogenesis, clinical presentation, differential diagnosis, and treatments for lipedema. The current research indicates that lipedema appears to be a clinical entity related to genetic factors and fat distribution, although distinct from lymphedema and obesity. Some available treatments include complex decongestive physiotherapy, liposuction, and laser-assisted lipolysis. The management of lipedema is complex and differs from that of lymphedema. Further high-quality randomized controlled trials are urgently needed to continue advancing our understanding of this often neglected disease and exploring optimal medical and surgical treatment regimens tailored specifically for lipedema patients. In summary, despite frequent misdiagnosis, enhanced recognition, and research into customized therapeutic strategies for this poorly characterized but likely underdiagnosed disorder represent promising steps forward.http://www.thieme-connect.de/DOI/DOI?10.1055/a-2530-5875
spellingShingle Hatan Hisham Mortada
Abdulmalek W. Alhithlool
Nouf Z. AlBattal
Rashika K. Shetty
Ghaleb A. AL-Mekhlafi
Joon Pio Hong
Feras Alshomer
Lipedema: Clinical Features, Diagnosis, and Management
Archives of Plastic Surgery
title Lipedema: Clinical Features, Diagnosis, and Management
title_full Lipedema: Clinical Features, Diagnosis, and Management
title_fullStr Lipedema: Clinical Features, Diagnosis, and Management
title_full_unstemmed Lipedema: Clinical Features, Diagnosis, and Management
title_short Lipedema: Clinical Features, Diagnosis, and Management
title_sort lipedema clinical features diagnosis and management
url http://www.thieme-connect.de/DOI/DOI?10.1055/a-2530-5875
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