Role of ferroptosis in atrial fibrillation: a review
Cardiovascular disease remains the leading cause of mortality, with atrial fibrillation emerging as one of the most common conditions encountered in clinical practice. However, its underlying mechanisms remain poorly understood, prompting ongoing research. Ferroptosis, a recently discovered form of...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1362060/full |
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| author | Shaowei Fan Yuanhui Hu Jingjing Shi |
| author_facet | Shaowei Fan Yuanhui Hu Jingjing Shi |
| author_sort | Shaowei Fan |
| collection | DOAJ |
| description | Cardiovascular disease remains the leading cause of mortality, with atrial fibrillation emerging as one of the most common conditions encountered in clinical practice. However, its underlying mechanisms remain poorly understood, prompting ongoing research. Ferroptosis, a recently discovered form of regulated cell death characterized by lipid peroxidation and disrupted cellular redox balance leading to cell death due to iron overload, has attracted significant attention. Since its identification, ferroptosis has been extensively studied in various contexts, including cancer, stroke, myocardial ischemia/reperfusion injury, and heart failure. Growing evidence suggests that ferroptosis may also play a critical role in the onset and progression of atrial fibrillation, though research in this area is still limited. This article provides a concise overview of the potential mechanisms by which ferroptosis may contribute to the pathogenesis of atrial fibrillation. |
| format | Article |
| id | doaj-art-d93ed733e4234a0f928f70a4f8753716 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-d93ed733e4234a0f928f70a4f87537162025-02-06T07:09:15ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-02-011610.3389/fphar.2025.13620601362060Role of ferroptosis in atrial fibrillation: a reviewShaowei Fan0Yuanhui Hu1Jingjing Shi2Lugouqiao Second Community Health Service Center, China Aerospace Science & Industry Corporation 731 Hospital, Beijing, ChinaDepartment of Cardiological Medicine, China Academy of Chinese Medical Sciences Guang’anmen Hospital, Beijing, ChinaDepartment of Cardiological Medicine, China Academy of Chinese Medical Sciences Guang’anmen Hospital, Beijing, ChinaCardiovascular disease remains the leading cause of mortality, with atrial fibrillation emerging as one of the most common conditions encountered in clinical practice. However, its underlying mechanisms remain poorly understood, prompting ongoing research. Ferroptosis, a recently discovered form of regulated cell death characterized by lipid peroxidation and disrupted cellular redox balance leading to cell death due to iron overload, has attracted significant attention. Since its identification, ferroptosis has been extensively studied in various contexts, including cancer, stroke, myocardial ischemia/reperfusion injury, and heart failure. Growing evidence suggests that ferroptosis may also play a critical role in the onset and progression of atrial fibrillation, though research in this area is still limited. This article provides a concise overview of the potential mechanisms by which ferroptosis may contribute to the pathogenesis of atrial fibrillation.https://www.frontiersin.org/articles/10.3389/fphar.2025.1362060/fullferroptosisatrial fibrillationlipid peroxidationmyocardial infarctionautophagy |
| spellingShingle | Shaowei Fan Yuanhui Hu Jingjing Shi Role of ferroptosis in atrial fibrillation: a review Frontiers in Pharmacology ferroptosis atrial fibrillation lipid peroxidation myocardial infarction autophagy |
| title | Role of ferroptosis in atrial fibrillation: a review |
| title_full | Role of ferroptosis in atrial fibrillation: a review |
| title_fullStr | Role of ferroptosis in atrial fibrillation: a review |
| title_full_unstemmed | Role of ferroptosis in atrial fibrillation: a review |
| title_short | Role of ferroptosis in atrial fibrillation: a review |
| title_sort | role of ferroptosis in atrial fibrillation a review |
| topic | ferroptosis atrial fibrillation lipid peroxidation myocardial infarction autophagy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1362060/full |
| work_keys_str_mv | AT shaoweifan roleofferroptosisinatrialfibrillationareview AT yuanhuihu roleofferroptosisinatrialfibrillationareview AT jingjingshi roleofferroptosisinatrialfibrillationareview |