Survival Analysis of Ovarian Carcinosarcomas Depending on Platinum or Doxorubicin Based Adjuvant Chemotherapy
OBJECTIVE: To analyse the survival outcomes of women with ovarian carcinosarcoma according to platinum or doxorubicin based adjuvant chemotherapy protocols. STUDY DESIGN: This retrospective study was performed at Etlik Zübeyde Hanım and Zekai Tahir Burak Women’s Health Education and Research Hospi...
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| Format: | Article |
| Language: | English |
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Medical Network
2015-04-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/43 |
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| author | İlker Selçuk İpek Düzgüner Sevda Baş Taner Turan Afra Alkan Nurettin Boran Mehmet Mutlu Meydanlı Gökhan Tulunay |
| author_facet | İlker Selçuk İpek Düzgüner Sevda Baş Taner Turan Afra Alkan Nurettin Boran Mehmet Mutlu Meydanlı Gökhan Tulunay |
| author_sort | İlker Selçuk |
| collection | DOAJ |
| description |
OBJECTIVE: To analyse the survival outcomes of women with ovarian carcinosarcoma according to platinum or doxorubicin based adjuvant chemotherapy protocols.
STUDY DESIGN: This retrospective study was performed at Etlik Zübeyde Hanım and Zekai Tahir Burak Women’s Health Education and Research Hospitals, which are tertiary centers in Turkey. A total of 31 women with ovarian carcinosarcoma between January 1999 and January 2013 were evaluated retrospectively.
RESULTS: The mean age of patients was 53.84±10.13. Most of the patients were diagnosed with stage IIIC ovarian carcinosarcoma (n=21, 67.7%). Maximal debulking and optimal debulking was performed to 23 (74.2%) and 8 (25.8%) patients, respectively. Disease free survival was significantly shorter in stage IIIC patients when compared to stage IIIB patients (p=0.048). Disease free survival for one and three years according to the treatment protocol (platinum or doxorubicin based) was not significantly different (p=0.574). Additionally, three and five years overall survival was not significantly different (p=0.891) between the platinum and doxorubicin based chemotherapy protocols.
DISCUSSION: We did not find a significant difference in terms of disease free survival and overall survival between platinum and doxorubicin based adjuvant chemotherapy protocols in women with ovarian carcinosarcoma.
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| format | Article |
| id | doaj-art-d9930b0868b14db7b4ba946cf0836c1e |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2015-04-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-d9930b0868b14db7b4ba946cf0836c1e2025-02-11T21:25:21ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182015-04-0121138Survival Analysis of Ovarian Carcinosarcomas Depending on Platinum or Doxorubicin Based Adjuvant Chemotherapyİlker Selçuk0İpek Düzgüner1Sevda Baş2Taner Turan3Afra Alkan4Nurettin Boran5Mehmet Mutlu Meydanlı6Gökhan Tulunay7Gynecologic Oncology Unit Zekai Tahir Burak Women’s Health, Education and Research Hospital, AnkaraGynecologic Oncology Unit, Etlik Zubeyde Hanım Women Diseases, Education and Research Hospital, AnkaraGynecologic Oncology Unit Zekai Tahir Burak Women’s Health, Education and Research Hospital, AnkaraGynecologic Oncology Unit, Etlik Zubeyde Hanım Women Diseases, Education and Research Hospital, AnkaraDepartment of Biostatistics, Yıldırım Beyazit University Faculty of Medicine, AnkaraGynecologic Oncology Unit, Etlik Zubeyde Hanım Women Diseases, Education and Research Hospital, AnkaraGynecologic Oncology Unit Zekai Tahir Burak Women’s Health, Education and Research Hospital, AnkaraGynecologic Oncology Unit, Etlik Zubeyde Hanım Women Diseases, Education and Research Hospital, Ankara OBJECTIVE: To analyse the survival outcomes of women with ovarian carcinosarcoma according to platinum or doxorubicin based adjuvant chemotherapy protocols. STUDY DESIGN: This retrospective study was performed at Etlik Zübeyde Hanım and Zekai Tahir Burak Women’s Health Education and Research Hospitals, which are tertiary centers in Turkey. A total of 31 women with ovarian carcinosarcoma between January 1999 and January 2013 were evaluated retrospectively. RESULTS: The mean age of patients was 53.84±10.13. Most of the patients were diagnosed with stage IIIC ovarian carcinosarcoma (n=21, 67.7%). Maximal debulking and optimal debulking was performed to 23 (74.2%) and 8 (25.8%) patients, respectively. Disease free survival was significantly shorter in stage IIIC patients when compared to stage IIIB patients (p=0.048). Disease free survival for one and three years according to the treatment protocol (platinum or doxorubicin based) was not significantly different (p=0.574). Additionally, three and five years overall survival was not significantly different (p=0.891) between the platinum and doxorubicin based chemotherapy protocols. DISCUSSION: We did not find a significant difference in terms of disease free survival and overall survival between platinum and doxorubicin based adjuvant chemotherapy protocols in women with ovarian carcinosarcoma. https://gorm.com.tr/index.php/GORM/article/view/43Ovarian carcinosarcomaChemotheraphySurvivalPlatinumDoxorubicin |
| spellingShingle | İlker Selçuk İpek Düzgüner Sevda Baş Taner Turan Afra Alkan Nurettin Boran Mehmet Mutlu Meydanlı Gökhan Tulunay Survival Analysis of Ovarian Carcinosarcomas Depending on Platinum or Doxorubicin Based Adjuvant Chemotherapy Gynecology Obstetrics & Reproductive Medicine Ovarian carcinosarcoma Chemotheraphy Survival Platinum Doxorubicin |
| title | Survival Analysis of Ovarian Carcinosarcomas Depending on Platinum or Doxorubicin Based Adjuvant Chemotherapy |
| title_full | Survival Analysis of Ovarian Carcinosarcomas Depending on Platinum or Doxorubicin Based Adjuvant Chemotherapy |
| title_fullStr | Survival Analysis of Ovarian Carcinosarcomas Depending on Platinum or Doxorubicin Based Adjuvant Chemotherapy |
| title_full_unstemmed | Survival Analysis of Ovarian Carcinosarcomas Depending on Platinum or Doxorubicin Based Adjuvant Chemotherapy |
| title_short | Survival Analysis of Ovarian Carcinosarcomas Depending on Platinum or Doxorubicin Based Adjuvant Chemotherapy |
| title_sort | survival analysis of ovarian carcinosarcomas depending on platinum or doxorubicin based adjuvant chemotherapy |
| topic | Ovarian carcinosarcoma Chemotheraphy Survival Platinum Doxorubicin |
| url | https://gorm.com.tr/index.php/GORM/article/view/43 |
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