Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma
Glioblastoma (GBM) remains a formidable challenge in neuro-oncology due to its aggressive nature and propensity for therapeutic resistance. Anti-vascular endothelial growth factor (VEGF) therapies, although promising, often encounter resistance that limits their clinical efficacy. A multi-target and...
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| Format: | Article |
| Language: | English |
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Open Exploration
2024-09-01
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| Series: | Exploration of Drug Science |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100862/100862.pdf |
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| author | Sasikumar Jalajakumari Soumya Kesavan Rathi Arya Chandran Sheela Abhinand Padmanabhan Sunitha Ajitha Prabhakaran Athira Achuthsankar Sukumaran Nair Oommen V. Oommen Perumana R. Sudhakaran |
| author_facet | Sasikumar Jalajakumari Soumya Kesavan Rathi Arya Chandran Sheela Abhinand Padmanabhan Sunitha Ajitha Prabhakaran Athira Achuthsankar Sukumaran Nair Oommen V. Oommen Perumana R. Sudhakaran |
| author_sort | Sasikumar Jalajakumari Soumya |
| collection | DOAJ |
| description | Glioblastoma (GBM) remains a formidable challenge in neuro-oncology due to its aggressive nature and propensity for therapeutic resistance. Anti-vascular endothelial growth factor (VEGF) therapies, although promising, often encounter resistance that limits their clinical efficacy. A multi-target and multi-drug approach has emerged as compelling strategies to address this resistance to enhance the treatment outcomes. This review examines the complex environment of anti-VEGF resistant GBM and analyses a multi-target therapeutic approach using natural products. |
| format | Article |
| id | doaj-art-da57d2d855ad4ed0912c087c4620c95a |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Open Exploration |
| record_format | Article |
| series | Exploration of Drug Science |
| spelling | doaj-art-da57d2d855ad4ed0912c087c4620c95a2025-02-08T03:29:23ZengOpen ExplorationExploration of Drug Science2836-76772024-09-012556758210.37349/eds.2024.00062Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastomaSasikumar Jalajakumari Soumya0Kesavan Rathi Arya1https://orcid.org/0009-0004-5714-9524Chandran Sheela Abhinand2https://orcid.org/0000-0003-3417-7835Padmanabhan Sunitha3https://orcid.org/0000-0001-5359-9502Ajitha Prabhakaran Athira4Achuthsankar Sukumaran Nair5Oommen V. Oommen6Perumana R. Sudhakaran7https://orcid.org/0000-0002-3980-612XDepartment of Computational Biology and Bioinformatics, University of Kerala, Thiruvananthapuram 695581, Kerala, IndiaDepartment of Computational Biology and Bioinformatics, University of Kerala, Thiruvananthapuram 695581, Kerala, IndiaDepartment of Computational Biology and Bioinformatics, University of Kerala, Thiruvananthapuram 695581, Kerala, India; Center for Systems Biology and Molecular Medicine, Yenepoya Research Center, Yenepoya (Deemed to be University), Mangalore 575018, Karnataka, IndiaDepartment of Computational Biology and Bioinformatics, University of Kerala, Thiruvananthapuram 695581, Kerala, IndiaDepartment of Biochemistry, University of Kerala, Thiruvananthapuram 695581, Kerala, India; Department of Viral Vaccines, Institute of Advanced Virology, Thiruvananthapuram 695317, Kerala, IndiaDepartment of Computational Biology and Bioinformatics, University of Kerala, Thiruvananthapuram 695581, Kerala, IndiaDepartment of Computational Biology and Bioinformatics, University of Kerala, Thiruvananthapuram 695581, Kerala, IndiaDepartment of Computational Biology and Bioinformatics, University of Kerala, Thiruvananthapuram 695581, Kerala, IndiaGlioblastoma (GBM) remains a formidable challenge in neuro-oncology due to its aggressive nature and propensity for therapeutic resistance. Anti-vascular endothelial growth factor (VEGF) therapies, although promising, often encounter resistance that limits their clinical efficacy. A multi-target and multi-drug approach has emerged as compelling strategies to address this resistance to enhance the treatment outcomes. This review examines the complex environment of anti-VEGF resistant GBM and analyses a multi-target therapeutic approach using natural products.https://www.explorationpub.com/uploads/Article/A100862/100862.pdfglioblastomaanti-vegf resistancenatural productscomputational approach |
| spellingShingle | Sasikumar Jalajakumari Soumya Kesavan Rathi Arya Chandran Sheela Abhinand Padmanabhan Sunitha Ajitha Prabhakaran Athira Achuthsankar Sukumaran Nair Oommen V. Oommen Perumana R. Sudhakaran Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma Exploration of Drug Science glioblastoma anti-vegf resistance natural products computational approach |
| title | Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma |
| title_full | Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma |
| title_fullStr | Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma |
| title_full_unstemmed | Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma |
| title_short | Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma |
| title_sort | multi target and natural product based multi drug approach for anti vegf resistance in glioblastoma |
| topic | glioblastoma anti-vegf resistance natural products computational approach |
| url | https://www.explorationpub.com/uploads/Article/A100862/100862.pdf |
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