Comparison of Controlled Ovarian Stimulation Protocols on IVF Outcome in Normal and Poor Responders
OBJECTIVE: Aim of this study is determining the influence of luteal long GnRH agonist and GnRH antagonist protocols on IVF/ICSI cycle outcome in group of patients considered “normal responder” and influence of luteal long GnRH agonist, microdose flare-up agonist and GnRH antagonist protocols on IVF...
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| Format: | Article |
| Language: | English |
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Medical Network
2013-12-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/211 |
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| author | Deniz Esinler Fazilet Kübra Boynukalın İbrahim Esinler Tarık Aksu |
| author_facet | Deniz Esinler Fazilet Kübra Boynukalın İbrahim Esinler Tarık Aksu |
| author_sort | Deniz Esinler |
| collection | DOAJ |
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OBJECTIVE: Aim of this study is determining the influence of luteal long GnRH agonist and GnRH antagonist protocols on IVF/ICSI cycle outcome in group of patients considered “normal responder” and influence of luteal long GnRH agonist, microdose flare-up agonist and GnRH antagonist protocols on IVF/ICSI cycle outcome in a group of patients considered “poor responder”.
STUDY DESIGN: This was a retrospective analysis performed in the Hacettepe University School of Medicine IVF Center, Ankara, from January 2005 to December 2007. Normal responders (first arm) were stimulated either with luteal long GnRH analogues, (193 patients and 300 cycles) or with GnRH antagonists (215 patients and 300 cycles). Poor responders (second arm) were stimulated either with luteal long GnRH analogues, (20 patients and 32 cycles), with GnRH antagonists (21 patients and 45 cycles) or microdose flare-up protocol (27 patients and 74 cycles).
RESULTS: In the first arm; the clinical pregnancy, implantation and multiple pregnancy rates were comparable between the two groups in the first arm. In the second arm; clinical pregnancy, implantation and multiple pregnancy rates were comparable between three groups.
CONCLUSION: There is insufficient evidence to recommend GnRH agonist or GnRH antagonist protocols for patients considered “normal’ and ‘poor responder’.
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| format | Article |
| id | doaj-art-db3bc40a7311455f8175bd23aee49892 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2013-12-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-db3bc40a7311455f8175bd23aee498922025-02-11T21:22:14ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182013-12-01193149Comparison of Controlled Ovarian Stimulation Protocols on IVF Outcome in Normal and Poor RespondersDeniz Esinler0Fazilet Kübra Boynukalın1İbrahim Esinler2Tarık Aksu3Hacettepe University Medical School Department of Obstetrics and Gynecology, AnkaraHacettepe University Medical School Department of Obstetrics and Gynecology, AnkaraHacettepe University Medical School Department of Obstetrics and Gynecology, AnkaraHacettepe University Medical School Department of Obstetrics and Gynecology, Ankara OBJECTIVE: Aim of this study is determining the influence of luteal long GnRH agonist and GnRH antagonist protocols on IVF/ICSI cycle outcome in group of patients considered “normal responder” and influence of luteal long GnRH agonist, microdose flare-up agonist and GnRH antagonist protocols on IVF/ICSI cycle outcome in a group of patients considered “poor responder”. STUDY DESIGN: This was a retrospective analysis performed in the Hacettepe University School of Medicine IVF Center, Ankara, from January 2005 to December 2007. Normal responders (first arm) were stimulated either with luteal long GnRH analogues, (193 patients and 300 cycles) or with GnRH antagonists (215 patients and 300 cycles). Poor responders (second arm) were stimulated either with luteal long GnRH analogues, (20 patients and 32 cycles), with GnRH antagonists (21 patients and 45 cycles) or microdose flare-up protocol (27 patients and 74 cycles). RESULTS: In the first arm; the clinical pregnancy, implantation and multiple pregnancy rates were comparable between the two groups in the first arm. In the second arm; clinical pregnancy, implantation and multiple pregnancy rates were comparable between three groups. CONCLUSION: There is insufficient evidence to recommend GnRH agonist or GnRH antagonist protocols for patients considered “normal’ and ‘poor responder’. https://gorm.com.tr/index.php/GORM/article/view/211GnRH antagonistGnRH agonistMicrodose flare-upIVF |
| spellingShingle | Deniz Esinler Fazilet Kübra Boynukalın İbrahim Esinler Tarık Aksu Comparison of Controlled Ovarian Stimulation Protocols on IVF Outcome in Normal and Poor Responders Gynecology Obstetrics & Reproductive Medicine GnRH antagonist GnRH agonist Microdose flare-up IVF |
| title | Comparison of Controlled Ovarian Stimulation Protocols on IVF Outcome in Normal and Poor Responders |
| title_full | Comparison of Controlled Ovarian Stimulation Protocols on IVF Outcome in Normal and Poor Responders |
| title_fullStr | Comparison of Controlled Ovarian Stimulation Protocols on IVF Outcome in Normal and Poor Responders |
| title_full_unstemmed | Comparison of Controlled Ovarian Stimulation Protocols on IVF Outcome in Normal and Poor Responders |
| title_short | Comparison of Controlled Ovarian Stimulation Protocols on IVF Outcome in Normal and Poor Responders |
| title_sort | comparison of controlled ovarian stimulation protocols on ivf outcome in normal and poor responders |
| topic | GnRH antagonist GnRH agonist Microdose flare-up IVF |
| url | https://gorm.com.tr/index.php/GORM/article/view/211 |
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