Synthesis and in vitro evaluation of spirobenzovesamicols as potential 11C-PET tracer alternatives to [18F]FEOBV for vesicular acetylcholine transporter (VAChT) imaging

Synthesis and in vitro evaluation of spirobenzovesamicols as potential 11C-PET tracer alternatives to [18F]FEOBV for vesicular acetylcholine transporter (VAChT) imaging

Abstract Background Through its central role in neurotransmission, the vesicular acetylcholine transporter (VAChT) is an increasingly valuable target for positron emission tomography (PET). VAChT ligands have been mostly derived from the vesamicol structure, but with limitations in available labelli...

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Bibliographic Details
Main Authors: Hugo Helbert, Winnie Deuther-Conrad, Michel de Haan, Barbara Wenzel, Gert Luurtsema, Wiktor Szymanski, Peter Brust, Rudi A. J. O. Dierckx, Ben L. Feringa, Philip H. Elsinga
Format: Article
Language:English
Published: SpringerOpen 2025-02-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
VAChT
11C-PET tracer
Spirobenzovesamicol
[18F]FEOBV
[11C]MeLi
Online Access:https://doi.org/10.1186/s41181-025-00327-w
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