Association of arterial stiffness and eye disease: a systematic review and meta-analysis
Background This systematic review and meta-analysis assesses the association of arterial stiffness with age-related macular degeneration (AMD), glaucoma, retinal vein occlusion (RVO) and retinopathy (diabetic and hypertensive).Methods Medline and Embase were systematically searched for observational...
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BMJ Publishing Group
2025-01-01
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| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/10/1/e001980.full |
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| author | Robert Scragg Angela L Beros John D Sluyter |
| author_facet | Robert Scragg Angela L Beros John D Sluyter |
| author_sort | Robert Scragg |
| collection | DOAJ |
| description | Background This systematic review and meta-analysis assesses the association of arterial stiffness with age-related macular degeneration (AMD), glaucoma, retinal vein occlusion (RVO) and retinopathy (diabetic and hypertensive).Methods Medline and Embase were systematically searched for observational studies of arterial stiffness and eye disease. Cohort studies were included if they estimated arterial stiffness using any measures based on the arterial waveform, with cross-sectional and case-control studies limited to measures of pulse wave velocity. We assessed the certainty of evidence using Grading of Recommendations, Assessment, Development and Evaluation.Results The systematic review of 61 studies (six for AMD, ten for glaucoma, six for RVO and 39 for retinopathy) showed that arterial stiffness overall was higher in people with eye disease than people without eye disease. Forty-four cross-sectional and case-control studies were included in the meta-analysis. Arterial stiffness estimated by way of pulse wave velocity was associated with AMD (mean difference: 0.92 m/s, 95% CI 0.37 to 1.46; 2 studies; n=381; low certainty evidence), glaucoma (mean difference: 0.97 m/s, 95% CI 0.31 to 1.64; 7 studies; n=3418; low certainty evidence), RVO (mean difference: 2.79 m/s, 95% CI 2.02 to 3.55; 5 studies; n=414; very low certainty evidence) and retinopathy (1.48 m/s, 95% CI 0.1.16 to 1.81; 22 studies; n=10 074; low certainty evidence). The 19 cohort studies identified (five for AMD, three for glaucoma, one for RVO and 10 for retinopathy) indicated overall that increased arterial stiffness was associated with the future development of eye disease.Conclusions Higher arterial stiffness is associated with AMD, glaucoma, RVO and retinopathyPROSPERO registration number CRD42019129563. |
| format | Article |
| id | doaj-art-dbc2b5b5df7e4275a4e88c7257f346ce |
| institution | Kabale University |
| issn | 2397-3269 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Ophthalmology |
| spelling | doaj-art-dbc2b5b5df7e4275a4e88c7257f346ce2025-02-10T11:55:09ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692025-01-0110110.1136/bmjophth-2024-001980Association of arterial stiffness and eye disease: a systematic review and meta-analysisRobert Scragg0Angela L Beros1John D Sluyter23 School of Population Health, The University of Auckland, Auckland, New ZealandSchool of Population Health, University of Auckland, Auckland, New ZealandSchool of Population Health, University of Auckland, Auckland, New ZealandBackground This systematic review and meta-analysis assesses the association of arterial stiffness with age-related macular degeneration (AMD), glaucoma, retinal vein occlusion (RVO) and retinopathy (diabetic and hypertensive).Methods Medline and Embase were systematically searched for observational studies of arterial stiffness and eye disease. Cohort studies were included if they estimated arterial stiffness using any measures based on the arterial waveform, with cross-sectional and case-control studies limited to measures of pulse wave velocity. We assessed the certainty of evidence using Grading of Recommendations, Assessment, Development and Evaluation.Results The systematic review of 61 studies (six for AMD, ten for glaucoma, six for RVO and 39 for retinopathy) showed that arterial stiffness overall was higher in people with eye disease than people without eye disease. Forty-four cross-sectional and case-control studies were included in the meta-analysis. Arterial stiffness estimated by way of pulse wave velocity was associated with AMD (mean difference: 0.92 m/s, 95% CI 0.37 to 1.46; 2 studies; n=381; low certainty evidence), glaucoma (mean difference: 0.97 m/s, 95% CI 0.31 to 1.64; 7 studies; n=3418; low certainty evidence), RVO (mean difference: 2.79 m/s, 95% CI 2.02 to 3.55; 5 studies; n=414; very low certainty evidence) and retinopathy (1.48 m/s, 95% CI 0.1.16 to 1.81; 22 studies; n=10 074; low certainty evidence). The 19 cohort studies identified (five for AMD, three for glaucoma, one for RVO and 10 for retinopathy) indicated overall that increased arterial stiffness was associated with the future development of eye disease.Conclusions Higher arterial stiffness is associated with AMD, glaucoma, RVO and retinopathyPROSPERO registration number CRD42019129563.https://bmjophth.bmj.com/content/10/1/e001980.full |
| spellingShingle | Robert Scragg Angela L Beros John D Sluyter Association of arterial stiffness and eye disease: a systematic review and meta-analysis BMJ Open Ophthalmology |
| title | Association of arterial stiffness and eye disease: a systematic review and meta-analysis |
| title_full | Association of arterial stiffness and eye disease: a systematic review and meta-analysis |
| title_fullStr | Association of arterial stiffness and eye disease: a systematic review and meta-analysis |
| title_full_unstemmed | Association of arterial stiffness and eye disease: a systematic review and meta-analysis |
| title_short | Association of arterial stiffness and eye disease: a systematic review and meta-analysis |
| title_sort | association of arterial stiffness and eye disease a systematic review and meta analysis |
| url | https://bmjophth.bmj.com/content/10/1/e001980.full |
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