Inhibition of the Transforming Growth Factor-β Signaling Pathway Confers Neuroprotective Effects on Beta-Amyloid-Induced Direct Neurotoxicity and Microglia-Mediated Neuroinflammation
Conclusion: The inhibition of the TGF-β signaling pathway in neuronal and microglia cells by TGF-βR1 inhibitors resulted in neuroprotection against Aβ-induced direct neurotoxicity and microglia-mediated neuroinflammation. Hence, targeting the TGF-β signaling pathway in both neuronal and microglia ce...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/nri/8948290 |
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| _version_ | 1825206984389951488 |
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| author | Shao Qin Tiong Raxshanaa N. Mohgan Jia Yee Quek Jennifer Yue Suan Liew Grace Yee Seen Wong Zi Qing Thang Zhi Ling Chan Sook Yee Gan Elaine Wan Ling Chan |
| author_facet | Shao Qin Tiong Raxshanaa N. Mohgan Jia Yee Quek Jennifer Yue Suan Liew Grace Yee Seen Wong Zi Qing Thang Zhi Ling Chan Sook Yee Gan Elaine Wan Ling Chan |
| author_sort | Shao Qin Tiong |
| collection | DOAJ |
| description | Conclusion: The inhibition of the TGF-β signaling pathway in neuronal and microglia cells by TGF-βR1 inhibitors resulted in neuroprotection against Aβ-induced direct neurotoxicity and microglia-mediated neuroinflammation. Hence, targeting the TGF-β signaling pathway in both neuronal and microglia cells could provide a promising therapeutic strategy in AD. |
| format | Article |
| id | doaj-art-dbd1f8e923444b9e87b4d73610f24aae |
| institution | Kabale University |
| issn | 2090-1860 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-dbd1f8e923444b9e87b4d73610f24aae2025-02-07T00:47:29ZengWileyNeurology Research International2090-18602025-01-01202510.1155/nri/8948290Inhibition of the Transforming Growth Factor-β Signaling Pathway Confers Neuroprotective Effects on Beta-Amyloid-Induced Direct Neurotoxicity and Microglia-Mediated NeuroinflammationShao Qin Tiong0Raxshanaa N. Mohgan1Jia Yee Quek2Jennifer Yue Suan Liew3Grace Yee Seen Wong4Zi Qing Thang5Zhi Ling Chan6Sook Yee Gan7Elaine Wan Ling Chan8School of PharmacySchool of PharmacySchool of PharmacySchool of PharmacySchool of PharmacySchool of PharmacySchool of PharmacySchool of PharmacyInstitute for Research, Development and InnovationConclusion: The inhibition of the TGF-β signaling pathway in neuronal and microglia cells by TGF-βR1 inhibitors resulted in neuroprotection against Aβ-induced direct neurotoxicity and microglia-mediated neuroinflammation. Hence, targeting the TGF-β signaling pathway in both neuronal and microglia cells could provide a promising therapeutic strategy in AD.http://dx.doi.org/10.1155/nri/8948290 |
| spellingShingle | Shao Qin Tiong Raxshanaa N. Mohgan Jia Yee Quek Jennifer Yue Suan Liew Grace Yee Seen Wong Zi Qing Thang Zhi Ling Chan Sook Yee Gan Elaine Wan Ling Chan Inhibition of the Transforming Growth Factor-β Signaling Pathway Confers Neuroprotective Effects on Beta-Amyloid-Induced Direct Neurotoxicity and Microglia-Mediated Neuroinflammation Neurology Research International |
| title | Inhibition of the Transforming Growth Factor-β Signaling Pathway Confers Neuroprotective Effects on Beta-Amyloid-Induced Direct Neurotoxicity and Microglia-Mediated Neuroinflammation |
| title_full | Inhibition of the Transforming Growth Factor-β Signaling Pathway Confers Neuroprotective Effects on Beta-Amyloid-Induced Direct Neurotoxicity and Microglia-Mediated Neuroinflammation |
| title_fullStr | Inhibition of the Transforming Growth Factor-β Signaling Pathway Confers Neuroprotective Effects on Beta-Amyloid-Induced Direct Neurotoxicity and Microglia-Mediated Neuroinflammation |
| title_full_unstemmed | Inhibition of the Transforming Growth Factor-β Signaling Pathway Confers Neuroprotective Effects on Beta-Amyloid-Induced Direct Neurotoxicity and Microglia-Mediated Neuroinflammation |
| title_short | Inhibition of the Transforming Growth Factor-β Signaling Pathway Confers Neuroprotective Effects on Beta-Amyloid-Induced Direct Neurotoxicity and Microglia-Mediated Neuroinflammation |
| title_sort | inhibition of the transforming growth factor β signaling pathway confers neuroprotective effects on beta amyloid induced direct neurotoxicity and microglia mediated neuroinflammation |
| url | http://dx.doi.org/10.1155/nri/8948290 |
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