Risk factors for loss to follow-up in patients with gout: A Korean prospective cohort study.
<h4>Objectives</h4>Gout, a common form of inflammatory arthritis, is often managed with urate-lowering therapy, but many patients only adhere to treatment during gout attacks, resulting in poor follow-up and suboptimal management. This study aimed to identify characteristics associated w...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0318564 |
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| author | Hyunsue Do Chang-Nam Son Hyo Jin Choi Ji Hyoun Kim Min Jung Kim Kichul Shin Sang-Hyon Kim Byoongyong Choi You-Jung Ha Joong Kyong Ahn Hyun-Ok Kim Sung Won Lee Chang Hoon Lee Ran Song Kyeong Min Son Seung-Geun Lee Ki Won Moon |
| author_facet | Hyunsue Do Chang-Nam Son Hyo Jin Choi Ji Hyoun Kim Min Jung Kim Kichul Shin Sang-Hyon Kim Byoongyong Choi You-Jung Ha Joong Kyong Ahn Hyun-Ok Kim Sung Won Lee Chang Hoon Lee Ran Song Kyeong Min Son Seung-Geun Lee Ki Won Moon |
| author_sort | Hyunsue Do |
| collection | DOAJ |
| description | <h4>Objectives</h4>Gout, a common form of inflammatory arthritis, is often managed with urate-lowering therapy, but many patients only adhere to treatment during gout attacks, resulting in poor follow-up and suboptimal management. This study aimed to identify characteristics associated with loss to follow-up (LTFU) and develop strategies for better patient management.<h4>Methods</h4>Data were analyzed from the Urate Lowering TheRApy in gout (ULTRA) registry, a prospective cohort of Korean gout patients recruited since September 2021. Patients aged 18 or older who met the 2015 ACR/EULAR classification criteria were included. Demographic data, clinical characteristics, lifestyle habits, comorbidities, and quality of life assessments using the Korean Gout Impact Scale (K-GIS) and EuroQol 5-Dimension (EQ-5D) were collected at baseline, six months, and annually. LTFU was defined as missing a clinic visit for more than a year. Logistic regression was used to determine factors associated with LTFU.<h4>Results</h4>Among 269 patients, 125 (46.5%) were classified as LTFU. Patients not lost to follow-up experienced more frequent gout attacks (P = 0.020) and expressed greater concerns about future flares (P = 0.034). In contrast, LTFU patients had higher levels of anxiety (P = 0.049), depressive symptoms (P = 0.009), impaired mobility (P = 0.002), and a higher EQ-5D score (P = 0.002). Logistic regression identified frequent gout attacks, concerns about attacks, anxiety, impaired mobility, and EQ-5D scores as significant predictors of LTFU.<h4>Conclusion</h4>Fewer gout attacks, heightened anxiety and depression, and lower quality of life were key factors associated with LTFU. Providing emotional support and comprehensive education may enhance follow-up and improve gout management. |
| format | Article |
| id | doaj-art-dc08afda14b54f0389bc1926f154ae67 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-dc08afda14b54f0389bc1926f154ae672025-02-12T05:31:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01202e031856410.1371/journal.pone.0318564Risk factors for loss to follow-up in patients with gout: A Korean prospective cohort study.Hyunsue DoChang-Nam SonHyo Jin ChoiJi Hyoun KimMin Jung KimKichul ShinSang-Hyon KimByoongyong ChoiYou-Jung HaJoong Kyong AhnHyun-Ok KimSung Won LeeChang Hoon LeeRan SongKyeong Min SonSeung-Geun LeeKi Won Moon<h4>Objectives</h4>Gout, a common form of inflammatory arthritis, is often managed with urate-lowering therapy, but many patients only adhere to treatment during gout attacks, resulting in poor follow-up and suboptimal management. This study aimed to identify characteristics associated with loss to follow-up (LTFU) and develop strategies for better patient management.<h4>Methods</h4>Data were analyzed from the Urate Lowering TheRApy in gout (ULTRA) registry, a prospective cohort of Korean gout patients recruited since September 2021. Patients aged 18 or older who met the 2015 ACR/EULAR classification criteria were included. Demographic data, clinical characteristics, lifestyle habits, comorbidities, and quality of life assessments using the Korean Gout Impact Scale (K-GIS) and EuroQol 5-Dimension (EQ-5D) were collected at baseline, six months, and annually. LTFU was defined as missing a clinic visit for more than a year. Logistic regression was used to determine factors associated with LTFU.<h4>Results</h4>Among 269 patients, 125 (46.5%) were classified as LTFU. Patients not lost to follow-up experienced more frequent gout attacks (P = 0.020) and expressed greater concerns about future flares (P = 0.034). In contrast, LTFU patients had higher levels of anxiety (P = 0.049), depressive symptoms (P = 0.009), impaired mobility (P = 0.002), and a higher EQ-5D score (P = 0.002). Logistic regression identified frequent gout attacks, concerns about attacks, anxiety, impaired mobility, and EQ-5D scores as significant predictors of LTFU.<h4>Conclusion</h4>Fewer gout attacks, heightened anxiety and depression, and lower quality of life were key factors associated with LTFU. Providing emotional support and comprehensive education may enhance follow-up and improve gout management.https://doi.org/10.1371/journal.pone.0318564 |
| spellingShingle | Hyunsue Do Chang-Nam Son Hyo Jin Choi Ji Hyoun Kim Min Jung Kim Kichul Shin Sang-Hyon Kim Byoongyong Choi You-Jung Ha Joong Kyong Ahn Hyun-Ok Kim Sung Won Lee Chang Hoon Lee Ran Song Kyeong Min Son Seung-Geun Lee Ki Won Moon Risk factors for loss to follow-up in patients with gout: A Korean prospective cohort study. PLoS ONE |
| title | Risk factors for loss to follow-up in patients with gout: A Korean prospective cohort study. |
| title_full | Risk factors for loss to follow-up in patients with gout: A Korean prospective cohort study. |
| title_fullStr | Risk factors for loss to follow-up in patients with gout: A Korean prospective cohort study. |
| title_full_unstemmed | Risk factors for loss to follow-up in patients with gout: A Korean prospective cohort study. |
| title_short | Risk factors for loss to follow-up in patients with gout: A Korean prospective cohort study. |
| title_sort | risk factors for loss to follow up in patients with gout a korean prospective cohort study |
| url | https://doi.org/10.1371/journal.pone.0318564 |
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