Precision nanoparticles for drug delivery, cell therapy tracking, and theranostics
For more than two decades, nanoparticles have attracted a great deal of attention from researchers and developers. When properly designed, vectorized nanoparticles represent high-value-added tools with potentially invaluable properties in a number of areas, including biology, biotechnology, and medi...
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| Format: | Article |
| Language: | English |
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Académie des sciences
2024-11-01
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| Series: | Comptes Rendus. Chimie |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.348/ |
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| author | Felder-Flesch, Delphine Talamini, Laura Muller, Sylviane |
| author_facet | Felder-Flesch, Delphine Talamini, Laura Muller, Sylviane |
| author_sort | Felder-Flesch, Delphine |
| collection | DOAJ |
| description | For more than two decades, nanoparticles have attracted a great deal of attention from researchers and developers. When properly designed, vectorized nanoparticles represent high-value-added tools with potentially invaluable properties in a number of areas, including biology, biotechnology, and medicine owing to their exceptional physico-chemical properties, especially resulting from their high surface area, high loading capacity, and nanoscale size. Smart design and building of nanoparticles through appropriate surface chemistry and functionalization provide a material that possesses multifunctional capabilities, able to specifically interact with a selected target, release a compound in a controlled and sustained way, and overcome, if desired, biological barriers such as the blood–brain barrier or lung barriers of interest. Unique constructions have thus opened up original and innovative possibilities in biotechnological and biomedical fields such as imaging, biosensors, rapid diagnostics, drug delivery, medical implants, and tissue engineering. This article briefly describes the main types of nanoparticles that have been developed and their advantages and disadvantages depending on the intended application, and highlights some remarkable results achieved recently in the biomedical field. Certain dangers or fears regarding their use in human and animal therapy or for users have been mentioned. Finally, conclusions and future perspectives are provided. |
| format | Article |
| id | doaj-art-dc0cc7bd60c54ae2a68d17a2db517d2d |
| institution | Kabale University |
| issn | 1878-1543 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj-art-dc0cc7bd60c54ae2a68d17a2db517d2d2025-02-07T13:39:46ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432024-11-0127G124125410.5802/crchim.34810.5802/crchim.348Precision nanoparticles for drug delivery, cell therapy tracking, and theranosticsFelder-Flesch, Delphine0https://orcid.org/0000-0003-3174-4072Talamini, Laura1https://orcid.org/0000-0001-6010-2947Muller, Sylviane2https://orcid.org/0000-0002-0481-0620CNRS and Strasbourg University, Institute of Physics and Chemistry of Materials (IPCMS), UMR 7504 Strasbourg, France; SUPERBRANCHE SAS Strasbourg, FranceCNRS and Strasbourg University, Unit Biotechnology and Cell Signaling, UMR7242 Strasbourg, France; Strasbourg Drug Discovery and Development Institute (IMS), Strasbourg, FranceCNRS and Strasbourg University, Unit Biotechnology and Cell Signaling, UMR7242 Strasbourg, France; Strasbourg Drug Discovery and Development Institute (IMS), Strasbourg, France; University of Strasbourg Institute for Advanced Study (USIAS), Strasbourg, FranceFor more than two decades, nanoparticles have attracted a great deal of attention from researchers and developers. When properly designed, vectorized nanoparticles represent high-value-added tools with potentially invaluable properties in a number of areas, including biology, biotechnology, and medicine owing to their exceptional physico-chemical properties, especially resulting from their high surface area, high loading capacity, and nanoscale size. Smart design and building of nanoparticles through appropriate surface chemistry and functionalization provide a material that possesses multifunctional capabilities, able to specifically interact with a selected target, release a compound in a controlled and sustained way, and overcome, if desired, biological barriers such as the blood–brain barrier or lung barriers of interest. Unique constructions have thus opened up original and innovative possibilities in biotechnological and biomedical fields such as imaging, biosensors, rapid diagnostics, drug delivery, medical implants, and tissue engineering. This article briefly describes the main types of nanoparticles that have been developed and their advantages and disadvantages depending on the intended application, and highlights some remarkable results achieved recently in the biomedical field. Certain dangers or fears regarding their use in human and animal therapy or for users have been mentioned. Finally, conclusions and future perspectives are provided.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.348/Multifunctional nanoparticlesTissue targetingPrecision medicineCell therapiesExtracellular vesiclesNanotheranosticsCancer and inflammation |
| spellingShingle | Felder-Flesch, Delphine Talamini, Laura Muller, Sylviane Precision nanoparticles for drug delivery, cell therapy tracking, and theranostics Comptes Rendus. Chimie Multifunctional nanoparticles Tissue targeting Precision medicine Cell therapies Extracellular vesicles Nanotheranostics Cancer and inflammation |
| title | Precision nanoparticles for drug delivery, cell therapy tracking, and theranostics |
| title_full | Precision nanoparticles for drug delivery, cell therapy tracking, and theranostics |
| title_fullStr | Precision nanoparticles for drug delivery, cell therapy tracking, and theranostics |
| title_full_unstemmed | Precision nanoparticles for drug delivery, cell therapy tracking, and theranostics |
| title_short | Precision nanoparticles for drug delivery, cell therapy tracking, and theranostics |
| title_sort | precision nanoparticles for drug delivery cell therapy tracking and theranostics |
| topic | Multifunctional nanoparticles Tissue targeting Precision medicine Cell therapies Extracellular vesicles Nanotheranostics Cancer and inflammation |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.348/ |
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