Comparison of different GnRH compounds on fertility outcomes in ovulation synchronized and presynchronized beef cows
This study evaluated the use of two different gonadotropin-releasing hormone (GnRH) compounds in estrus synchronization protocols with or without presynchronization. Cows (n = 1,585) were enrolled in a completely randomized design with a 2×2 factorial arrangement of treatments. Within each location,...
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Frontiers Media S.A.
2025-02-01
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| author | Nicola Oosthuizen Lucas M. Goncalves Samir Burato Molly S. Smith Kelsey M. Harvey Graham Cliff Lamb Graham Cliff Lamb Pedro L. P. Fontes |
| author_facet | Nicola Oosthuizen Lucas M. Goncalves Samir Burato Molly S. Smith Kelsey M. Harvey Graham Cliff Lamb Graham Cliff Lamb Pedro L. P. Fontes |
| author_sort | Nicola Oosthuizen |
| collection | DOAJ |
| description | This study evaluated the use of two different gonadotropin-releasing hormone (GnRH) compounds in estrus synchronization protocols with or without presynchronization. Cows (n = 1,585) were enrolled in a completely randomized design with a 2×2 factorial arrangement of treatments. Within each location, cows were randomly assigned to one of four treatments: (1 and 2) cows were estrus synchronized using the 7-day CO-Synch + CIDR protocol (7D) wherein they received an injection of one of two GnRH compounds [gonadorelin hydrochloride (GH) or gonadorelin diacetate tetrahydrate (GDT)] and a controlled internal drug release (CIDR) device on day 0, an injection of prostaglandin F2α (PG) at CIDR removal on day 7, and a second injection of their respective GnRH compound at fixed-time artificial insemination (TAI) on day 10 (7D-GH and 7D-GHT); (3 and 4) cows were treated with the 7&7 Synch (7&7) protocol, wherein they were treated the same as treatments 1 and 2 but received their CIDR inserts on day -7 in conjunction with an injection of PG (7&7-GH and 7&7-GDT). Breeding indicator patches were applied to all cows at CIDR removal and were evaluated for activation at TAI. Follicle diameter differed by ovulation synchronization protocol on days 0, 7, and 10, where cows enrolled in the 7&7 had greater (P ≤ 0.008) dominant follicle diameters than those in the 7D. No differences (P ≥ 0.19) in ovarian parameters were determined between GH and GDT cows. Estrus expression differed (P < 0.001) by synchronization protocol and was greater in cows enrolled in the 7&7 than the 7D (80.4 ± 2.8 vs. 55.5 ± 4.1%, respectively), yet no differences (P = 0.32) in estrus expression were determined between GH- and GDT-treated cows. Pregnancy rates to TAI did not differ (P = 0.57) by GnRH compound but differed (P = 0.01) by synchronization protocol, where cows enrolled in the 7&7 had greater PR/AI when compared to those in the 7D (60.9 ± 2.5 vs. 53.9 ± 2.6%, respectively). In conclusion, fertility was improved through the use of presynchronization; however, no differences in fertility parameters were determined between GH and GDT in either synchronized or presynchronized beef cows. |
| format | Article |
| id | doaj-art-dc7d46891910465c895fe2547e19848a |
| institution | Kabale University |
| issn | 2673-6225 |
| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-dc7d46891910465c895fe2547e19848a2025-02-11T13:38:31ZengFrontiers Media S.A.Frontiers in Animal Science2673-62252025-02-01610.3389/fanim.2025.15029841502984Comparison of different GnRH compounds on fertility outcomes in ovulation synchronized and presynchronized beef cowsNicola Oosthuizen0Lucas M. Goncalves1Samir Burato2Molly S. Smith3Kelsey M. Harvey4Graham Cliff Lamb5Graham Cliff Lamb6Pedro L. P. Fontes7ABS Global, DeForest, WI, United StatesDepartment of Animal and Dairy Science, University of Georgia, Athens, GA, United StatesDepartment of Animal and Dairy Science, University of Georgia, Athens, GA, United StatesDepartment of Animal and Dairy Science, University of Georgia, Athens, GA, United StatesPrairie Research Unit, Mississippi State University, Prairie, MS, United StatesDepartment of Animal Science, Texas A&M University, College Station, TX, United StatesTexas A&M AgriLife Research, College Station, TX, United StatesDepartment of Animal and Dairy Science, University of Georgia, Athens, GA, United StatesThis study evaluated the use of two different gonadotropin-releasing hormone (GnRH) compounds in estrus synchronization protocols with or without presynchronization. Cows (n = 1,585) were enrolled in a completely randomized design with a 2×2 factorial arrangement of treatments. Within each location, cows were randomly assigned to one of four treatments: (1 and 2) cows were estrus synchronized using the 7-day CO-Synch + CIDR protocol (7D) wherein they received an injection of one of two GnRH compounds [gonadorelin hydrochloride (GH) or gonadorelin diacetate tetrahydrate (GDT)] and a controlled internal drug release (CIDR) device on day 0, an injection of prostaglandin F2α (PG) at CIDR removal on day 7, and a second injection of their respective GnRH compound at fixed-time artificial insemination (TAI) on day 10 (7D-GH and 7D-GHT); (3 and 4) cows were treated with the 7&7 Synch (7&7) protocol, wherein they were treated the same as treatments 1 and 2 but received their CIDR inserts on day -7 in conjunction with an injection of PG (7&7-GH and 7&7-GDT). Breeding indicator patches were applied to all cows at CIDR removal and were evaluated for activation at TAI. Follicle diameter differed by ovulation synchronization protocol on days 0, 7, and 10, where cows enrolled in the 7&7 had greater (P ≤ 0.008) dominant follicle diameters than those in the 7D. No differences (P ≥ 0.19) in ovarian parameters were determined between GH and GDT cows. Estrus expression differed (P < 0.001) by synchronization protocol and was greater in cows enrolled in the 7&7 than the 7D (80.4 ± 2.8 vs. 55.5 ± 4.1%, respectively), yet no differences (P = 0.32) in estrus expression were determined between GH- and GDT-treated cows. Pregnancy rates to TAI did not differ (P = 0.57) by GnRH compound but differed (P = 0.01) by synchronization protocol, where cows enrolled in the 7&7 had greater PR/AI when compared to those in the 7D (60.9 ± 2.5 vs. 53.9 ± 2.6%, respectively). In conclusion, fertility was improved through the use of presynchronization; however, no differences in fertility parameters were determined between GH and GDT in either synchronized or presynchronized beef cows.https://www.frontiersin.org/articles/10.3389/fanim.2025.1502984/fullbeef cowsGnRHgonadorelin diacetate tetrahydrategonadorelin hydrochloridepresynchronization |
| spellingShingle | Nicola Oosthuizen Lucas M. Goncalves Samir Burato Molly S. Smith Kelsey M. Harvey Graham Cliff Lamb Graham Cliff Lamb Pedro L. P. Fontes Comparison of different GnRH compounds on fertility outcomes in ovulation synchronized and presynchronized beef cows Frontiers in Animal Science beef cows GnRH gonadorelin diacetate tetrahydrate gonadorelin hydrochloride presynchronization |
| title | Comparison of different GnRH compounds on fertility outcomes in ovulation synchronized and presynchronized beef cows |
| title_full | Comparison of different GnRH compounds on fertility outcomes in ovulation synchronized and presynchronized beef cows |
| title_fullStr | Comparison of different GnRH compounds on fertility outcomes in ovulation synchronized and presynchronized beef cows |
| title_full_unstemmed | Comparison of different GnRH compounds on fertility outcomes in ovulation synchronized and presynchronized beef cows |
| title_short | Comparison of different GnRH compounds on fertility outcomes in ovulation synchronized and presynchronized beef cows |
| title_sort | comparison of different gnrh compounds on fertility outcomes in ovulation synchronized and presynchronized beef cows |
| topic | beef cows GnRH gonadorelin diacetate tetrahydrate gonadorelin hydrochloride presynchronization |
| url | https://www.frontiersin.org/articles/10.3389/fanim.2025.1502984/full |
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