A normal electrocardiogram indicates a better prognosis in patients with moderate to very severe chronic obstructive pulmonary disease
Abstract The role of electrocardiography (ECG) in predicting mortality in patients with chronic obstructive pulmonary disease (COPD) has not been sufficiently established. Research question: Is a normal ECG associated with a better prognosis than an abnormal ECG in patients with COPD? ECG parameters...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-89013-0 |
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| author | Martina Kulirova Miroslav Solar Michal Kopecky Barbora Novotna Marek Plutinsky Kristian Brat Libor Fila Petr Vanik Pavlina Musilova Tomas Dvorak Petr Safranek Michal Svoboda Vladimir Koblizek |
| author_facet | Martina Kulirova Miroslav Solar Michal Kopecky Barbora Novotna Marek Plutinsky Kristian Brat Libor Fila Petr Vanik Pavlina Musilova Tomas Dvorak Petr Safranek Michal Svoboda Vladimir Koblizek |
| author_sort | Martina Kulirova |
| collection | DOAJ |
| description | Abstract The role of electrocardiography (ECG) in predicting mortality in patients with chronic obstructive pulmonary disease (COPD) has not been sufficiently established. Research question: Is a normal ECG associated with a better prognosis than an abnormal ECG in patients with COPD? ECG parameters were assessed in patients enrolled in the Czech Multicenter Research Database of COPD. We assessed ECGs from baseline (August 2013) until December 31, 2019, or until death. The primary endpoint was 5-year overall survival depending on the ECG findings. A total of 300 subjects were enrolled in the study and 143 died during follow-up. This multicenter noninterventional observational prospective study revealed a significant difference in 5-year overall survival between COPD patients with normal ECGs and those with prognostically significant or other ECG abnormalities (76.8%, 38.2%, and 63.4%, respectively; P < 0.001). Patients with prognostically significant ECG abnormalities had a 2.537-fold greater mortality risk at 5 years than those with normal ECGs. In the COPD setting, patients with normal ECGs had a better prognosis than those with prognostically significant abnormalities suggesting that ECG may be a valuable tool for predicting mortality risk in these patients. |
| format | Article |
| id | doaj-art-dd32f90c892e4c489258211a51100725 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-dd32f90c892e4c489258211a511007252025-02-09T12:34:18ZengNature PortfolioScientific Reports2045-23222025-02-0115111210.1038/s41598-025-89013-0A normal electrocardiogram indicates a better prognosis in patients with moderate to very severe chronic obstructive pulmonary diseaseMartina Kulirova0Miroslav Solar1Michal Kopecky2Barbora Novotna3Marek Plutinsky4Kristian Brat5Libor Fila6Petr Vanik7Pavlina Musilova8Tomas Dvorak9Petr Safranek10Michal Svoboda11Vladimir Koblizek12Department of Pneumology, University Hospital Hradec KraloveFaculty of Medicine in Hradec Kralove, Charles UniversityDepartment of Pneumology, University Hospital Hradec KraloveDepartment of Pneumology, Bulovka University HospitalDepartment of Respiratory Diseases, University Hospital BrnoDepartment of Respiratory Diseases, University Hospital BrnoDepartment of Pneumology, Faculty of Medicine, Charles University, Motol University HospitalPulmonary Department, Ceske Budejovice HospitalDepartment of Pneumology, Hospital JihlavaDepartment of Pneumology, Klaudian HospitalEUC Clinic PlzenInstitute of Biostatistics and Analyses, Masaryk University BrnoDepartment of Pneumology, University Hospital Hradec KraloveAbstract The role of electrocardiography (ECG) in predicting mortality in patients with chronic obstructive pulmonary disease (COPD) has not been sufficiently established. Research question: Is a normal ECG associated with a better prognosis than an abnormal ECG in patients with COPD? ECG parameters were assessed in patients enrolled in the Czech Multicenter Research Database of COPD. We assessed ECGs from baseline (August 2013) until December 31, 2019, or until death. The primary endpoint was 5-year overall survival depending on the ECG findings. A total of 300 subjects were enrolled in the study and 143 died during follow-up. This multicenter noninterventional observational prospective study revealed a significant difference in 5-year overall survival between COPD patients with normal ECGs and those with prognostically significant or other ECG abnormalities (76.8%, 38.2%, and 63.4%, respectively; P < 0.001). Patients with prognostically significant ECG abnormalities had a 2.537-fold greater mortality risk at 5 years than those with normal ECGs. In the COPD setting, patients with normal ECGs had a better prognosis than those with prognostically significant abnormalities suggesting that ECG may be a valuable tool for predicting mortality risk in these patients.https://doi.org/10.1038/s41598-025-89013-0Chronic obstructive pulmonary diseaseElectrocardiographyMortalityPrognosis |
| spellingShingle | Martina Kulirova Miroslav Solar Michal Kopecky Barbora Novotna Marek Plutinsky Kristian Brat Libor Fila Petr Vanik Pavlina Musilova Tomas Dvorak Petr Safranek Michal Svoboda Vladimir Koblizek A normal electrocardiogram indicates a better prognosis in patients with moderate to very severe chronic obstructive pulmonary disease Scientific Reports Chronic obstructive pulmonary disease Electrocardiography Mortality Prognosis |
| title | A normal electrocardiogram indicates a better prognosis in patients with moderate to very severe chronic obstructive pulmonary disease |
| title_full | A normal electrocardiogram indicates a better prognosis in patients with moderate to very severe chronic obstructive pulmonary disease |
| title_fullStr | A normal electrocardiogram indicates a better prognosis in patients with moderate to very severe chronic obstructive pulmonary disease |
| title_full_unstemmed | A normal electrocardiogram indicates a better prognosis in patients with moderate to very severe chronic obstructive pulmonary disease |
| title_short | A normal electrocardiogram indicates a better prognosis in patients with moderate to very severe chronic obstructive pulmonary disease |
| title_sort | normal electrocardiogram indicates a better prognosis in patients with moderate to very severe chronic obstructive pulmonary disease |
| topic | Chronic obstructive pulmonary disease Electrocardiography Mortality Prognosis |
| url | https://doi.org/10.1038/s41598-025-89013-0 |
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