Structural and Functional Fundamentals of Alcoholic Disease
Aim. To suggest a new perspective on chronic alcohol intoxication by means of investigating the associated severe multiple organ pathology, which frequently becomes the cause of lethal outcome in patients suffering from drunkenness and alcoholism.Key points. The empirical basis of the study consiste...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2018-11-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/259 |
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| author | V. S. Paukov T. M. Voronina Yu. A. Kirillov E. M. Malysheva |
| author_facet | V. S. Paukov T. M. Voronina Yu. A. Kirillov E. M. Malysheva |
| author_sort | V. S. Paukov |
| collection | DOAJ |
| description | Aim. To suggest a new perspective on chronic alcohol intoxication by means of investigating the associated severe multiple organ pathology, which frequently becomes the cause of lethal outcome in patients suffering from drunkenness and alcoholism.Key points. The empirical basis of the study consisted in the analysis of autopsy results obtained from 1,115 corpses of persons having abused alcohol during their lifetime. In addition, 800 experiments on rats were carried out. As a result, a concept of alcoholic disease (AD) is proposed. AD is defined as a condition, in which chronic ethanol intoxication leads to the development of morphological changes in organs and systems: from minimal injuries of the microcirculatory pathway to a multiple organ pathology showing signs of alcoholism. AD pathogenesis is demonstrated to undergo 3 major stages, from (1) episodic alcohol intoxication, through (2) drunkenness and to (3) alcoholism. It is noted that, while the morphological changes are considered to be reversible during the first two stages, they become irreversible at the stage of alcoholism.Conclusion. It is concluded that the forms of the disease that involve the described morphological changes in organs and systems should be primarily treated by physicians, not by psychiatrists and narcology practitioners who are only capable of dealing with the psychological aspect of the problem. |
| format | Article |
| id | doaj-art-dd3592bdbb0c41c1ad04c43486081655 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-11-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-dd3592bdbb0c41c1ad04c434860816552025-02-10T16:14:35ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-11-0128571710.22416/1382-4376-2018-28-5-7-17258Structural and Functional Fundamentals of Alcoholic DiseaseV. S. Paukov0T. M. Voronina1Yu. A. Kirillov2E. M. Malysheva3I.M. Sechenov First Moscow State Medical University, Department of Pathological Anatomy named after Academician A.I. Strukov.I.M. Sechenov First Moscow State Medical University, Department of Pathological Anatomy named after Academician A.I. Strukov.Moscow City Clinical Hospital No. 40.I.M. Sechenov First Moscow State Medical University, Department of Pathological Anatomy named after Academician A.I. Strukov.Aim. To suggest a new perspective on chronic alcohol intoxication by means of investigating the associated severe multiple organ pathology, which frequently becomes the cause of lethal outcome in patients suffering from drunkenness and alcoholism.Key points. The empirical basis of the study consisted in the analysis of autopsy results obtained from 1,115 corpses of persons having abused alcohol during their lifetime. In addition, 800 experiments on rats were carried out. As a result, a concept of alcoholic disease (AD) is proposed. AD is defined as a condition, in which chronic ethanol intoxication leads to the development of morphological changes in organs and systems: from minimal injuries of the microcirculatory pathway to a multiple organ pathology showing signs of alcoholism. AD pathogenesis is demonstrated to undergo 3 major stages, from (1) episodic alcohol intoxication, through (2) drunkenness and to (3) alcoholism. It is noted that, while the morphological changes are considered to be reversible during the first two stages, they become irreversible at the stage of alcoholism.Conclusion. It is concluded that the forms of the disease that involve the described morphological changes in organs and systems should be primarily treated by physicians, not by psychiatrists and narcology practitioners who are only capable of dealing with the psychological aspect of the problem.https://www.gastro-j.ru/jour/article/view/259alcoholic diseasealcoholic disease pathogenesis stagesalcoholic disease morphological changesreversible alcoholic disease stagedrunkenness |
| spellingShingle | V. S. Paukov T. M. Voronina Yu. A. Kirillov E. M. Malysheva Structural and Functional Fundamentals of Alcoholic Disease Российский журнал гастроэнтерологии, гепатологии, колопроктологии alcoholic disease alcoholic disease pathogenesis stages alcoholic disease morphological changes reversible alcoholic disease stage drunkenness |
| title | Structural and Functional Fundamentals of Alcoholic Disease |
| title_full | Structural and Functional Fundamentals of Alcoholic Disease |
| title_fullStr | Structural and Functional Fundamentals of Alcoholic Disease |
| title_full_unstemmed | Structural and Functional Fundamentals of Alcoholic Disease |
| title_short | Structural and Functional Fundamentals of Alcoholic Disease |
| title_sort | structural and functional fundamentals of alcoholic disease |
| topic | alcoholic disease alcoholic disease pathogenesis stages alcoholic disease morphological changes reversible alcoholic disease stage drunkenness |
| url | https://www.gastro-j.ru/jour/article/view/259 |
| work_keys_str_mv | AT vspaukov structuralandfunctionalfundamentalsofalcoholicdisease AT tmvoronina structuralandfunctionalfundamentalsofalcoholicdisease AT yuakirillov structuralandfunctionalfundamentalsofalcoholicdisease AT emmalysheva structuralandfunctionalfundamentalsofalcoholicdisease |