Stem Cell–Based Therapies via Different Administration Route for Stroke: A Meta-analysis of Comparative Studies
Stroke, a neurological condition from compromised cerebral blood perfusion, remains a major global cause of mortality and disability. Conventional therapies like tissue plasminogen activator are limited by narrow therapeutic windows and potential adverse effects, highlighting the urgency for novel t...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-02-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/09636897251315121 |
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| author | Gabriella Jeanne Mulia Novelia Anna John Chung-Che Wu Hon-Ping Ma Yung-Hsiao Chiang Ju-Chi Ou Kai-Yun Chen |
| author_facet | Gabriella Jeanne Mulia Novelia Anna John Chung-Che Wu Hon-Ping Ma Yung-Hsiao Chiang Ju-Chi Ou Kai-Yun Chen |
| author_sort | Gabriella Jeanne Mulia |
| collection | DOAJ |
| description | Stroke, a neurological condition from compromised cerebral blood perfusion, remains a major global cause of mortality and disability. Conventional therapies like tissue plasminogen activator are limited by narrow therapeutic windows and potential adverse effects, highlighting the urgency for novel treatments. Stem cell–based therapies, with their neuroprotective and regenerative properties, present a promising yet highly diverse alternative. By conducting literature search and data extraction from the PubMed, Embase, and Cochrane databases, this meta-analysis assessed the clinical efficacy and safety of stem cell–based therapies administered via intravenous (IV) and non-IV routes in 17 studies with stroke patients. Primary outcomes included the National Institute of Health Stroke Scale (NIHSS), Barthel Index (BI), and modified Rankin Scale (mRS), while secondary outcomes included mortality and adverse events. Results demonstrated significant improvements in NIHSS, BI, and mRS scores, particularly in non-IV groups within 6- and 12-month follow-ups, suggesting delayed but enhanced therapeutic efficacy. Mortality was reduced in both IV and non-IV groups, indicating treatment safety. Adverse events, categorized into neurological and systemic complications, showed no significant differences between intervention and control groups, further emphasizing the safety of stem cell therapies. Non-IV routes showed more long-term benefits, potentially due to enhanced cell delivery and integration. These findings demonstrate the potential of stem cell therapies to improve functional recovery and survival in stroke patients, regardless of administration route. However, the delayed response underscores the need for extended follow-up in clinical applications. Further research is required to standardize treatment protocols, optimize cell types and doses, and address patient-specific factors to integrate stem cell therapies into routine clinical practice. |
| format | Article |
| id | doaj-art-de5e1781484941f1b6a4336a1cfe1485 |
| institution | Kabale University |
| issn | 1555-3892 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj-art-de5e1781484941f1b6a4336a1cfe14852025-02-10T11:04:31ZengSAGE PublishingCell Transplantation1555-38922025-02-013410.1177/09636897251315121Stem Cell–Based Therapies via Different Administration Route for Stroke: A Meta-analysis of Comparative StudiesGabriella Jeanne Mulia0Novelia Anna1John Chung-Che Wu2Hon-Ping Ma3Yung-Hsiao Chiang4Ju-Chi Ou5Kai-Yun Chen6International Master Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, TaipeiDepartment of Biotechnology, Indonesia International Institute for Life Sciences, East Jakarta, IndonesiaTaipei Neuroscience Institute, Taipei Medical University, TaipeiDepartment of Emergency medicine, Shuang Ho Hospital, Taipei Medical University, TaipeiTaipei Neuroscience Institute, Taipei Medical University, TaipeiResearch Center for Neuroscience, Taipei Medical University, TaipeiPhD Program in Medical Neuroscience, Taipei Medical University, Taipei, TaiwanStroke, a neurological condition from compromised cerebral blood perfusion, remains a major global cause of mortality and disability. Conventional therapies like tissue plasminogen activator are limited by narrow therapeutic windows and potential adverse effects, highlighting the urgency for novel treatments. Stem cell–based therapies, with their neuroprotective and regenerative properties, present a promising yet highly diverse alternative. By conducting literature search and data extraction from the PubMed, Embase, and Cochrane databases, this meta-analysis assessed the clinical efficacy and safety of stem cell–based therapies administered via intravenous (IV) and non-IV routes in 17 studies with stroke patients. Primary outcomes included the National Institute of Health Stroke Scale (NIHSS), Barthel Index (BI), and modified Rankin Scale (mRS), while secondary outcomes included mortality and adverse events. Results demonstrated significant improvements in NIHSS, BI, and mRS scores, particularly in non-IV groups within 6- and 12-month follow-ups, suggesting delayed but enhanced therapeutic efficacy. Mortality was reduced in both IV and non-IV groups, indicating treatment safety. Adverse events, categorized into neurological and systemic complications, showed no significant differences between intervention and control groups, further emphasizing the safety of stem cell therapies. Non-IV routes showed more long-term benefits, potentially due to enhanced cell delivery and integration. These findings demonstrate the potential of stem cell therapies to improve functional recovery and survival in stroke patients, regardless of administration route. However, the delayed response underscores the need for extended follow-up in clinical applications. Further research is required to standardize treatment protocols, optimize cell types and doses, and address patient-specific factors to integrate stem cell therapies into routine clinical practice.https://doi.org/10.1177/09636897251315121 |
| spellingShingle | Gabriella Jeanne Mulia Novelia Anna John Chung-Che Wu Hon-Ping Ma Yung-Hsiao Chiang Ju-Chi Ou Kai-Yun Chen Stem Cell–Based Therapies via Different Administration Route for Stroke: A Meta-analysis of Comparative Studies Cell Transplantation |
| title | Stem Cell–Based Therapies via Different Administration Route for Stroke: A Meta-analysis of Comparative Studies |
| title_full | Stem Cell–Based Therapies via Different Administration Route for Stroke: A Meta-analysis of Comparative Studies |
| title_fullStr | Stem Cell–Based Therapies via Different Administration Route for Stroke: A Meta-analysis of Comparative Studies |
| title_full_unstemmed | Stem Cell–Based Therapies via Different Administration Route for Stroke: A Meta-analysis of Comparative Studies |
| title_short | Stem Cell–Based Therapies via Different Administration Route for Stroke: A Meta-analysis of Comparative Studies |
| title_sort | stem cell based therapies via different administration route for stroke a meta analysis of comparative studies |
| url | https://doi.org/10.1177/09636897251315121 |
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