Development of a novel wireless telemetric brain stimulator for behavioral studies in rodents
Brain simulators are moving the field of neuroscience at a rapid pace due to their wide applicability in treating neurodegenerative disorders. Although continuing advances in the field have made significant breakthroughs, most brain simulators remain too expensive for general clinical applications W...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Ain Shams Engineering Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090447925000310 |
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| author | V. Milner Paul Jijo Francis Smriti Menon Loitongbam Surajkumar Singh Adarsh V. Parekkattil Shuma Adhikari |
| author_facet | V. Milner Paul Jijo Francis Smriti Menon Loitongbam Surajkumar Singh Adarsh V. Parekkattil Shuma Adhikari |
| author_sort | V. Milner Paul |
| collection | DOAJ |
| description | Brain simulators are moving the field of neuroscience at a rapid pace due to their wide applicability in treating neurodegenerative disorders. Although continuing advances in the field have made significant breakthroughs, most brain simulators remain too expensive for general clinical applications We developed a user friendly, cost effective, multi-channel wireless brain stimulator that delivers output with high precision. The multichannel output of this device makes it amenable to conducting behavioral studies on different regions of the brain in rodents. The efficacy of our head-mountable device is substantiated by conducting intracranial and intracortical experiments in rats. We tested the output of the device by changing the ifrequency (100 Hz–400 Hz), amplitude, pulse width and current (10 µA – 1 mA) of the stimulator by altering the ON time period of the pulses and resistor values. We have defined optimum frequency (140 Hz) for the intracranial experiment and lower and upper threshold currents for the intracortical experiment. The successful feasibility of this device has been demonstrated invivo in rats and invitro in saline solution. Real-time experiments like Intracranial Self Stimulation (ICSS) and Intracortical Microstimulation (ICMS) tests were successful during the animal experiment to evaluate this brain stimulator. Our device has widespread applicability in conducting behavior-based studies and deriving insights into various mechanistic pathways in rodent brain. |
| format | Article |
| id | doaj-art-def7782f22c64ca495a826664e9f7917 |
| institution | Kabale University |
| issn | 2090-4479 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ain Shams Engineering Journal |
| spelling | doaj-art-def7782f22c64ca495a826664e9f79172025-02-09T05:00:01ZengElsevierAin Shams Engineering Journal2090-44792025-03-01163103290Development of a novel wireless telemetric brain stimulator for behavioral studies in rodentsV. Milner Paul0Jijo Francis1Smriti Menon2Loitongbam Surajkumar Singh3Adarsh V. Parekkattil4Shuma Adhikari5Department of Electrical Engineering, National Institute of Technology Manipur (NITM), IndiaChrist College (Autonomous), Irinjalakuda 680125, IndiaDepartment of Biotechnology, St. Mary’s College, Thrissur 680020, IndiaDepartment of Electronics and Communication Engineering, National Institute of Technology Manipur (NITM), IndiaDepartment of Electronics and Communication, Indian Institute of Technology Roorkee (IITR), IndiaDepartment of Electrical Engineering, National Institute of Technology Manipur (NITM), India; Corresponding author.Brain simulators are moving the field of neuroscience at a rapid pace due to their wide applicability in treating neurodegenerative disorders. Although continuing advances in the field have made significant breakthroughs, most brain simulators remain too expensive for general clinical applications We developed a user friendly, cost effective, multi-channel wireless brain stimulator that delivers output with high precision. The multichannel output of this device makes it amenable to conducting behavioral studies on different regions of the brain in rodents. The efficacy of our head-mountable device is substantiated by conducting intracranial and intracortical experiments in rats. We tested the output of the device by changing the ifrequency (100 Hz–400 Hz), amplitude, pulse width and current (10 µA – 1 mA) of the stimulator by altering the ON time period of the pulses and resistor values. We have defined optimum frequency (140 Hz) for the intracranial experiment and lower and upper threshold currents for the intracortical experiment. The successful feasibility of this device has been demonstrated invivo in rats and invitro in saline solution. Real-time experiments like Intracranial Self Stimulation (ICSS) and Intracortical Microstimulation (ICMS) tests were successful during the animal experiment to evaluate this brain stimulator. Our device has widespread applicability in conducting behavior-based studies and deriving insights into various mechanistic pathways in rodent brain.http://www.sciencedirect.com/science/article/pii/S2090447925000310StimulatorIntracortical microstimulationBrain-computer interfaceEmbedded SYSTEMNeuro-circuit intracranial self-stimulation rodents |
| spellingShingle | V. Milner Paul Jijo Francis Smriti Menon Loitongbam Surajkumar Singh Adarsh V. Parekkattil Shuma Adhikari Development of a novel wireless telemetric brain stimulator for behavioral studies in rodents Ain Shams Engineering Journal Stimulator Intracortical microstimulation Brain-computer interface Embedded SYSTEM Neuro-circuit intracranial self-stimulation rodents |
| title | Development of a novel wireless telemetric brain stimulator for behavioral studies in rodents |
| title_full | Development of a novel wireless telemetric brain stimulator for behavioral studies in rodents |
| title_fullStr | Development of a novel wireless telemetric brain stimulator for behavioral studies in rodents |
| title_full_unstemmed | Development of a novel wireless telemetric brain stimulator for behavioral studies in rodents |
| title_short | Development of a novel wireless telemetric brain stimulator for behavioral studies in rodents |
| title_sort | development of a novel wireless telemetric brain stimulator for behavioral studies in rodents |
| topic | Stimulator Intracortical microstimulation Brain-computer interface Embedded SYSTEM Neuro-circuit intracranial self-stimulation rodents |
| url | http://www.sciencedirect.com/science/article/pii/S2090447925000310 |
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