Assessment of Interleukin-1β in Saliva of Smoker and Non-smoker Patients with Chronic Periodontitis.
Background and objectives: Smoking is considered a significant risk factor in periodontitis. The pathogenesis of periodontal disease may be affected by alterations of the inflammatory response by smoke. Interleukin-1 (IL-1β), an effective pro-inflammatory cytokine have been associated with the immu...
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| Format: | Article |
| Language: | English |
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College Of Dentistry Hawler Medical University
2022-02-01
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| Series: | Erbil Dental Journal |
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| Online Access: | https://edj.hmu.edu.krd/index.php/journal/article/view/140 |
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| author | Solav Abdul-Qadir Mustafa Haween T. Nanakaly Hozan Wrya Azeez |
| author_facet | Solav Abdul-Qadir Mustafa Haween T. Nanakaly Hozan Wrya Azeez |
| author_sort | Solav Abdul-Qadir Mustafa |
| collection | DOAJ |
| description |
Background and objectives: Smoking is considered a significant risk factor in periodontitis. The pathogenesis of periodontal disease may be affected by alterations of the inflammatory response by smoke. Interleukin-1 (IL-1β), an effective pro-inflammatory cytokine have been associated with the immunopathology of periodontitis. The aim of this study was to assess the levels of IL-1β in saliva from smokers and non-smokers with chronic periodontitis and periodontally healthy controls.
Materials and methods: Gingival index, Plaque index, probing pocket depth, clinical attachment level, bleeding on probing were assessed in 84 subjects who were equally divided in to three groups. group I periodontally healthy non-smoking subjects ; group II non-smokers with chronic periodontitis; group III smokers with chronic periodontitis; Enzyme Linked Immunosorbent Assay (ELISA) test was used for quantification of Interleukin (IL)- 1β in the saliva samples. Statistical analysis were performed with SPSS version 22.0.
Results: Interleukin-1β level in saliva was significantly higher in smoker than in nonsmokers with chronic periodontitis and the controls (P˂ 0.001). In subjects with chronic periodontitis, a significant correlation existed between CAL and IL-β (r= 0.313, p= 0.052) among non-smokers; there was also a highly significant positive correlation between, CAL and IL-β (r= 0.310, p= 0.051), BOP and IL-β (r= 0.333, p= 0.05) among smokers.
Conclusion: Salivary IL-1β level were significantly elevated in periodontitis patients. Smokers with chronic periodontitis exhibited a highly significant increase in salivary IL-1β levels. Hence, this reflects the impact of smoking on immune response and its role in the pathogenesis of periodontal disease.
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| format | Article |
| id | doaj-art-dfe19c2493bc47feaf7aa7c4384ef1a5 |
| institution | Kabale University |
| issn | 2523-6172 2616-4795 |
| language | English |
| publishDate | 2022-02-01 |
| publisher | College Of Dentistry Hawler Medical University |
| record_format | Article |
| series | Erbil Dental Journal |
| spelling | doaj-art-dfe19c2493bc47feaf7aa7c4384ef1a52025-02-10T20:48:31ZengCollege Of Dentistry Hawler Medical UniversityErbil Dental Journal2523-61722616-47952022-02-0142Assessment of Interleukin-1β in Saliva of Smoker and Non-smoker Patients with Chronic Periodontitis.Solav Abdul-Qadir Mustafa0Haween T. Nanakaly1Hozan Wrya Azeez2Department of Periodontology, College of Dentistry, Hawler Medical University, Erbil, Iraq.Department of Basic Sciences, College of Dentistry, Hawler Medical University, Erbil, Iraq.Department of Periodontology, College of Dentistry, Hawler Medical University, Erbil, Iraq. Background and objectives: Smoking is considered a significant risk factor in periodontitis. The pathogenesis of periodontal disease may be affected by alterations of the inflammatory response by smoke. Interleukin-1 (IL-1β), an effective pro-inflammatory cytokine have been associated with the immunopathology of periodontitis. The aim of this study was to assess the levels of IL-1β in saliva from smokers and non-smokers with chronic periodontitis and periodontally healthy controls. Materials and methods: Gingival index, Plaque index, probing pocket depth, clinical attachment level, bleeding on probing were assessed in 84 subjects who were equally divided in to three groups. group I periodontally healthy non-smoking subjects ; group II non-smokers with chronic periodontitis; group III smokers with chronic periodontitis; Enzyme Linked Immunosorbent Assay (ELISA) test was used for quantification of Interleukin (IL)- 1β in the saliva samples. Statistical analysis were performed with SPSS version 22.0. Results: Interleukin-1β level in saliva was significantly higher in smoker than in nonsmokers with chronic periodontitis and the controls (P˂ 0.001). In subjects with chronic periodontitis, a significant correlation existed between CAL and IL-β (r= 0.313, p= 0.052) among non-smokers; there was also a highly significant positive correlation between, CAL and IL-β (r= 0.310, p= 0.051), BOP and IL-β (r= 0.333, p= 0.05) among smokers. Conclusion: Salivary IL-1β level were significantly elevated in periodontitis patients. Smokers with chronic periodontitis exhibited a highly significant increase in salivary IL-1β levels. Hence, this reflects the impact of smoking on immune response and its role in the pathogenesis of periodontal disease. https://edj.hmu.edu.krd/index.php/journal/article/view/140Chronic periodontitisSalivaInterleukin-1βSmoking |
| spellingShingle | Solav Abdul-Qadir Mustafa Haween T. Nanakaly Hozan Wrya Azeez Assessment of Interleukin-1β in Saliva of Smoker and Non-smoker Patients with Chronic Periodontitis. Erbil Dental Journal Chronic periodontitis Saliva Interleukin-1β Smoking |
| title | Assessment of Interleukin-1β in Saliva of Smoker and Non-smoker Patients with Chronic Periodontitis. |
| title_full | Assessment of Interleukin-1β in Saliva of Smoker and Non-smoker Patients with Chronic Periodontitis. |
| title_fullStr | Assessment of Interleukin-1β in Saliva of Smoker and Non-smoker Patients with Chronic Periodontitis. |
| title_full_unstemmed | Assessment of Interleukin-1β in Saliva of Smoker and Non-smoker Patients with Chronic Periodontitis. |
| title_short | Assessment of Interleukin-1β in Saliva of Smoker and Non-smoker Patients with Chronic Periodontitis. |
| title_sort | assessment of interleukin 1β in saliva of smoker and non smoker patients with chronic periodontitis |
| topic | Chronic periodontitis Saliva Interleukin-1β Smoking |
| url | https://edj.hmu.edu.krd/index.php/journal/article/view/140 |
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