Role of exhaled hydrogen sulfide in the diagnosis of colorectal cancer
Background Colorectal cancer (CRC) is often accompanied by increased excretion of hydrogen sulfide (H2S). This study aimed to explore the value of exhaled H2S in the diagnosis of CRC.Methods A total of 80 people with normal colonoscopy results and 57 patients with CRC were enrolled into the present...
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| Language: | English |
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BMJ Publishing Group
2024-05-01
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| Series: | BMJ Open Gastroenterology |
| Online Access: | https://bmjopengastro.bmj.com/content/11/1/e001229.full |
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| author | Jian Chen Yujen Tseng Peizhun Du Pengcheng Liu Huilu Zhang Guangjian Huang Cheng’en Hu |
| author_facet | Jian Chen Yujen Tseng Peizhun Du Pengcheng Liu Huilu Zhang Guangjian Huang Cheng’en Hu |
| author_sort | Jian Chen |
| collection | DOAJ |
| description | Background Colorectal cancer (CRC) is often accompanied by increased excretion of hydrogen sulfide (H2S). This study aimed to explore the value of exhaled H2S in the diagnosis of CRC.Methods A total of 80 people with normal colonoscopy results and 57 patients with CRC were enrolled into the present observational cohort study. Exhaled oral and nasal H2S were detected by Nanocoulomb breath analyser. Results were compared between the two groups. Receiver operating characteristic (ROC) curves were analysed and area under the curves (AUCs) were calculated to assess the diagnostic value of exhaled H2S. Meanwhile, the clinicopathological features, including gender, lesion location and tumour staging of patients with CRC, were also collected and analysed.Results The amount of exhaled H2S from patients with CRC was significantly higher than that of those with normal colonoscopy results. The ROC curve showed an AUC value of 0.73 and 0.71 based on oral and nasal H2S detection, respectively. The exhaled H2S in patients with CRC was correlated with gender, lesion location and tumour progression, including depth of invasion, lymphatic metastasis and TNM (Tumor, Lymph Nodes, Metastasis) staging.Conclusion Exhaled H2S analysis is a convenient and non-invasive detection method for diagnosing CRC, suggesting a potential role in population screening for CRC. |
| format | Article |
| id | doaj-art-e0b35785edf7401987b3af26828e4c37 |
| institution | Kabale University |
| issn | 2054-4774 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Gastroenterology |
| spelling | doaj-art-e0b35785edf7401987b3af26828e4c372025-02-12T07:45:15ZengBMJ Publishing GroupBMJ Open Gastroenterology2054-47742024-05-0111110.1136/bmjgast-2023-001229Role of exhaled hydrogen sulfide in the diagnosis of colorectal cancerJian Chen0Yujen Tseng1Peizhun Du2Pengcheng Liu3Huilu Zhang4Guangjian Huang5Cheng’en Hu6Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, ChinaHuashan Hospital Fudan University, Shanghai, ChinaDepartment of General Surgery, Huashan Hospital Fudan University, Shanghai, ChinaSchool of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, ChinaDepartment of Digestive Diseases, Huashan Hospital Fudan University, Shanghai, ChinaDepartment of General Surgery, Huashan Hospital Fudan University, Shanghai, ChinaDepartment of General Surgery, Huashan Hospital Fudan University, Shanghai, ChinaBackground Colorectal cancer (CRC) is often accompanied by increased excretion of hydrogen sulfide (H2S). This study aimed to explore the value of exhaled H2S in the diagnosis of CRC.Methods A total of 80 people with normal colonoscopy results and 57 patients with CRC were enrolled into the present observational cohort study. Exhaled oral and nasal H2S were detected by Nanocoulomb breath analyser. Results were compared between the two groups. Receiver operating characteristic (ROC) curves were analysed and area under the curves (AUCs) were calculated to assess the diagnostic value of exhaled H2S. Meanwhile, the clinicopathological features, including gender, lesion location and tumour staging of patients with CRC, were also collected and analysed.Results The amount of exhaled H2S from patients with CRC was significantly higher than that of those with normal colonoscopy results. The ROC curve showed an AUC value of 0.73 and 0.71 based on oral and nasal H2S detection, respectively. The exhaled H2S in patients with CRC was correlated with gender, lesion location and tumour progression, including depth of invasion, lymphatic metastasis and TNM (Tumor, Lymph Nodes, Metastasis) staging.Conclusion Exhaled H2S analysis is a convenient and non-invasive detection method for diagnosing CRC, suggesting a potential role in population screening for CRC.https://bmjopengastro.bmj.com/content/11/1/e001229.full |
| spellingShingle | Jian Chen Yujen Tseng Peizhun Du Pengcheng Liu Huilu Zhang Guangjian Huang Cheng’en Hu Role of exhaled hydrogen sulfide in the diagnosis of colorectal cancer BMJ Open Gastroenterology |
| title | Role of exhaled hydrogen sulfide in the diagnosis of colorectal cancer |
| title_full | Role of exhaled hydrogen sulfide in the diagnosis of colorectal cancer |
| title_fullStr | Role of exhaled hydrogen sulfide in the diagnosis of colorectal cancer |
| title_full_unstemmed | Role of exhaled hydrogen sulfide in the diagnosis of colorectal cancer |
| title_short | Role of exhaled hydrogen sulfide in the diagnosis of colorectal cancer |
| title_sort | role of exhaled hydrogen sulfide in the diagnosis of colorectal cancer |
| url | https://bmjopengastro.bmj.com/content/11/1/e001229.full |
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